SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption. | SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption. Alruwaili M, Armstrong S, Prince T, Erdmann M, Matthews DA, Luu L, Davidson A, Aljabr W, Hiscox JA., Free PMC Article | 12/6/2023 |
Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT. | Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT. Han W, Jin M, Liu C, Zhao Q, Wang S, Wang Y, Yin Y, Peng C, Wang Y, Cong Y., Free PMC Article | 03/22/2023 |
Co-occurrence of two rare genetic diseases: A potential pitfall for prenatal diagnosis in successive pregnancies. | Co-occurrence of two rare genetic diseases: A potential pitfall for prenatal diagnosis in successive pregnancies. He Y, Li DZ. | 10/23/2021 |
Association of tricellulin expression with poor colorectal cancer prognosis and metastasis. | Association of tricellulin expression with poor colorectal cancer prognosis and metastasis. Zhang JX, Qin MB, Ye Z, Peng P, Li SM, Song Q, Lin L, Liu SQ, Xie LH, Zhu Y, Huang JA., Free PMC Article | 07/10/2021 |
Recessive insertion variant in the MARVELD2 segregates with non-syndromic hearing loss in an Iranian family. | A novel pathogenic variant in the MARVELD2 gene causes autosomal recessive non-syndromic hearing loss in an Iranian family. Taghipour-Sheshdeh A, Nemati-Zargaran F, Zarepour N, Tahmasebi P, Saki N, Tabatabaiefar MA, Mohammadi-Asl J, Hashemzadeh-Chaleshtori M. | 01/4/2020 |
ELISA revealed that Crohn's Disease twins demonstrated significantly lower levels of tight junction protein tricellulin compared with external controls. | Gut Barrier Dysfunction-A Primary Defect in Twins with Crohn's Disease Predominantly Caused by Genetic Predisposition. Keita ÅV, Lindqvist CM, Öst Å, Magana CDL, Schoultz I, Halfvarson J., Free PMC Article | 03/2/2019 |
this study shows that tricellulin is regulated via interleukin-13-receptor alpha2, affects macromolecule uptake, and is decreased in ulcerative colitis | Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis. Krug SM, Bojarski C, Fromm A, Lee IM, Dames P, Richter JF, Turner JR, Fromm M, Schulzke JD., Free PMC Article | 12/22/2018 |
Our results provide new insights into the function of tricellulin, and its nuclear localization may become a new prognostic factor for pancreatic cancers. | Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer. Takasawa A, Murata M, Takasawa K, Ono Y, Osanai M, Tanaka S, Nojima M, Kono T, Hirata K, Kojima T, Sawada N., Free PMC Article | 06/9/2018 |
GSK3beta may inhibit VRK2 catalytic activity by disrupting its flexibility. The inhibition of VRK2 catalytic activity by GSK3beta may also inhibit VRK2-induced degradation of TRiC, which could suppress polyQ-expanded Htt aggregation. | Glycogen synthase kinase 3β suppresses polyglutamine aggregation by inhibiting Vaccinia-related kinase 2 activity. Lee E, Ryu HG, Kim S, Lee D, Jeong YH, Kim KT., Free PMC Article | 05/26/2018 |
Tricellulin-dependent macromolecule passage was comparably regulated in leaky and tight epithelia, but relative and absolute ion permeabilities of the tricellular tight junction (tTJ) were different. | Contribution of the tricellular tight junction to paracellular permeability in leaky and tight epithelia. Krug SM. | 08/26/2017 |
Data show that the E3 ubiquitin ligase Itch forms a complex with tricellulin and thereby enhances its ubiquitination. | Tricellulin is a target of the ubiquitin ligase Itch. Jennek S, Mittag S, Reiche J, Westphal JK, Seelk S, Dörfel MJ, Pfirrmann T, Friedrich K, Schütz A, Heinemann U, Huber O. | 08/26/2017 |
we demonstrated that PLG functions as a molecular bridge between tricellulin and streptococcal surface enolase (SEN). The wild type strain efficiently translocated across the epithelial monolayer, accompanied by cleavage of transmembrane junctional proteins. | Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions. Sumitomo T, Nakata M, Higashino M, Yamaguchi M, Kawabata S., Free PMC Article | 12/24/2016 |
The expressions of MARVELD2, CLDN1 and CLDN3 mRNA were significantly lower in cholesteatoma tissue and may be involved in epithelium permeability. | Increased permeability of the epithelium of middle ear cholesteatoma. Koizumi H, Suzuki H, Ohbuchi T, Kitamura T, Hashida K, Nakamura M. | 01/16/2016 |
High tricellulin expression is associated with hepatocellular carcinoma. | Tricellulin expression and its prognostic significance in primary liver carcinomas. Somorácz A, Korompay A, Törzsök P, Patonai A, Erdélyi-Belle B, Lotz G, Schaff Z, Kiss A. | 07/25/2015 |
MARVELD2 variants are responsible for about 1.5 % (95 % CI 0.8-2.6) of non-syndromic hearing loss in our cohort of 800 Pakistani families. The c.1331+2T>C allele is recurrent. | Molecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss. Nayak G, Varga L, Trincot C, Shahzad M, Friedman PL, Klimes I, Greinwald JH Jr, Riazuddin SA, Masindova I, Profant M, Khan SN, Friedman TB, Ahmed ZM, Gasperikova D, Riazuddin S, Riazuddin S., Free PMC Article | 05/16/2015 |
The findings show the heterogeneity of the molecular organization of tTJs in terms of the content of LSR, ILDR1 or ILDR2, and suggest that ILDR1-mediated recruitment of tricellulin to TCs is required for hearing. | Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2--tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis. Higashi T, Tokuda S, Kitajiri S, Masuda S, Nakamura H, Oda Y, Furuse M. | 11/23/2013 |
This study reveals the presence and subcellular distribution of tricellulin in brain endothelial cells. | Tricellulin expression in brain endothelial and neural cells. Mariano C, Palmela I, Pereira P, Fernandes A, Falcão AS, Cardoso FL, Vaz AR, Campos AR, Gonçalves-Ferreira A, Kim KS, Brites D, Brito MA. | 08/10/2013 |
The dynamic behavior of tricellulin during the destruction and formation of tight junctions (TJ) under various extracellular calcium conditions seems to be closely associated with the barrier and fence functions of TJs. | Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions. Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, Sawada N., Free PMC Article | 06/8/2013 |
DFNB49 is an important cause of non-syndromic deafness in Czech Roma patients but not in the general Czech population. | DFNB49 is an important cause of non-syndromic deafness in Czech Roma patients but not in the general Czech population. Šafka Brožková D, Laštůvková J, Štěpánková H, Krůtová M, Trková M, Myška P, Seeman P. | 04/13/2013 |
the tricellulin expression profile in normal and neoplastic human pancreas | Tricellulin expression in normal and neoplastic human pancreas. Korompay A, Borka K, Lotz G, Somorácz A, Törzsök P, Erdélyi-Belle B, Kenessey I, Baranyai Z, Zsoldos F, Kupcsulik P, Bodoky G, Schaff Z, Kiss A. | 09/15/2012 |
tricellulin and its role in tight junction formation and maintenance | A look at tricellulin and its role in tight junction formation and maintenance. Mariano C, Sasaki H, Brites D, Brito MA. | 12/31/2011 |
tricellulin is markedly reduced at all stages of tumor development. In situ hybridization analysis showed no correlation between HPV infection and altered expression of the tight junction proteins. | Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma. Kondoh A, Takano K, Kojima T, Ohkuni T, Kamekura R, Ogasawara N, Go M, Sawada N, Himi T. | 12/24/2011 |
the expression of tricellulin both in microglia and in the stomach immune cells point to a possible role of this new tight junctions protein in the immune system. | Evidence of tricellulin expression by immune cells, particularly microglia. Mariano C, Silva SL, Pereira P, Fernandes A, Brites D, Brito MA. | 09/3/2011 |
JNK may be involved in the regulation of tricellular tight junctions including TRIC expression and the barrier function in pancreatic duct epithelial cells. | c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells. Kojima T, Fuchimoto J, Yamaguchi H, Ito T, Takasawa A, Ninomiya T, Kikuchi S, Ogasawara N, Ohkuni T, Masaki T, Hirata K, Himi T, Sawada N. | 10/23/2010 |
marvelD3, occludin, and tricellulin define the tight junction-associated MARVEL protein family | Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, Turner JR., Free PMC Article | 08/9/2010 |