| Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus. | Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus.
Kleijwegt C, Bressac F, Seurre C, Bouchereau W, Cohen C, Texier P, Simonet T, Schaeffer L, Lomonte P, Corpet A., Free PMC Article | 06/12/2023 |
| The histone H3.3 chaperone HIRA restrains erythroid-biased differentiation of adult hematopoietic stem cells. | The histone H3.3 chaperone HIRA restrains erythroid-biased differentiation of adult hematopoietic stem cells.
Murdaugh RL, Hoegenauer KA, Kitano A, Holt MV, Hill MC, Shi X, Tiessen JF, Chapple R, Hu T, Tseng YJ, Lin A, Martin JF, Young NL, Nakada D., Free PMC Article | 03/19/2022 |
| HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs. | HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs.
Yang Y, Zhang L, Xiong C, Chen J, Wang L, Wen Z, Yu J, Chen P, Xu Y, Jin J, Cai Y, Li G., Free PMC Article | 02/19/2022 |
| HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype. | HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.
Smith R, Pickering SJ, Kopakaki A, Thong KJ, Anderson RA, Lin CJ., Free PMC Article | 01/8/2022 |
| Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker. | Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.
Blake GET, Zhao X, Yung HW, Burton GJ, Ferguson-Smith AC, Hamilton RS, Watson ED., Free PMC Article | 07/10/2021 |
| HIRA stabilizes skeletal muscle lineage identity. | HIRA stabilizes skeletal muscle lineage identity.
Esteves de Lima J, Bou Akar R, Machado L, Li Y, Drayton-Libotte B, Dilworth FJ, Relaix F., Free PMC Article | 06/19/2021 |
| Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth. | Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth.
Jeanne M, Vuillaume ML, Ung DC, Vancollie VE, Wagner C, Collins SC, Vonwill S, Haye D, Chelloug N, Pfundt R, Kummeling J, Moizard MP, Marouillat S, Kleefstra T, Yalcin B, Laumonnier F, Toutain A. | 05/15/2021 |
| HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis. | HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis.
Chen C, Sun MA, Warzecha C, Bachu M, Dey A, Wu T, Adams PD, Macfarlan T, Love P, Ozato K. | 03/13/2021 |
| These data suggest that elimination of HIRA produces a hypertrophic response in skeletal muscle and leaves myofibers susceptible to stress-induced degeneration. | HIRA deficiency in muscle fibers causes hypertrophy and susceptibility to oxidative stress.
Valenzuela N, Soibam B, Li L, Wang J, Byers LA, Liu Y, Schwartz RJ, Stewart MD. | 04/21/2018 |
| HIRA, in cooperation with Setd1A, modulates beta-catenin expression to regulate neural stem cell proliferation and neurogenesis. | Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin.
Li Y, Jiao J., Free PMC Article | 09/16/2017 |
| transcriptional regulation by HIRA is crucial for cardiomyocyte homeostasis. | Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis.
Valenzuela N, Fan Q, Fa'ak F, Soibam B, Nagandla H, Liu Y, Schwartz RJ, McConnell BK, Stewart MD., Free PMC Article | 12/17/2016 |
| Data show that Hira is important to mediates Histone H3/H4 replacement during mouse oogenesis which is required for normal 5mC deposition in oocytes. Its loss results in chromatin abnormalities and extensive oocyte loss. | Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis.
Nashun B, Hill PW, Smallwood SA, Dharmalingam G, Amouroux R, Clark SJ, Sharma V, Ndjetehe E, Pelczar P, Festenstein RJ, Kelsey G, Hajkova P., Free PMC Article | 03/12/2016 |
| HIRA is not only critical for beta-globin expression but is also required for activation of the erythropoietic regulators EKLF and GATA binding protein 1 (GATA1). | Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression.
Soni S, Pchelintsev N, Adams PD, Bieker JJ., Free PMC Article | 04/25/2015 |
| Hira-mediated H3.3 incorporation is essential for parental genome reprogramming and reveal an unexpected role for rRNA transcription in the mouse zygote | Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote.
Lin CJ, Koh FM, Wong P, Conti M, Ramalho-Santos M., Free PMC Article | 10/25/2014 |
| WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition. | WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.
Sarai N, Nimura K, Tamura T, Kanno T, Patel MC, Heightman TD, Ura K, Ozato K., Free PMC Article | 11/30/2013 |
| HIRA interacts with H3.3/H4 in the absence of Daxx. | HIRA and Daxx constitute two independent histone H3.3-containing predeposition complexes.
Elsaesser SJ, Allis CD. | 10/8/2011 |
| HIRA is an essential factor for muscle development by establishing MyoD activation in myotubes. | Myogenic transcriptional activation of MyoD mediated by replication-independent histone deposition.
Yang JH, Song Y, Seol JH, Park JY, Yang YJ, Han JW, Youn HD, Cho EJ., Free PMC Article | 02/26/2011 |
| Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality | Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality.
Roberts C, Sutherland HF, Farmer H, Kimber W, Halford S, Carey A, Brickman JM, Wynshaw-Boris A, Scambler PJ., Free PMC Article | 01/21/2010 |