TRPA1 Influences Staphylococcus aureus Skin Infection in Mice and Associates with HIF-1a and MAPK Pathway Modulation. | TRPA1 Influences Staphylococcus aureus Skin Infection in Mice and Associates with HIF-1a and MAPK Pathway Modulation. Yadav M, Chaudhary PP, Ratley G, D'Souza B, Kaur M, Ganesan S, Kabat J, Myles IA., Free PMC Article | 10/8/2024 |
ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1alpha. | ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1α. Kaur B, Miglioranza Scavuzzi B, Yang M, Yao J, Jia L, Abcouwer SF, Zacks DN., Free PMC Article | 10/1/2024 |
UCHL1-dependent control of hypoxia-inducible factor transcriptional activity during liver fibrosis. | UCHL1-dependent control of hypoxia-inducible factor transcriptional activity during liver fibrosis. Collins A, Scott R, Wilson CL, Abbate G, Ecclestone GB, Albanese AG, Biddles D, White S, French J, Moir J, Alrawashdeh W, Wilson C, Pandanaboyana S, Hammond JS, Thakkar R, Oakley F, Mann J, Mann DA, Kenneth NS., Free PMC Article | 10/1/2024 |
HIF1 activation safeguards cortical bone formation against impaired oxidative phosphorylation. | HIF1 activation safeguards cortical bone formation against impaired oxidative phosphorylation. Khan MP, Sabini E, Beigel K, Lanzolla G, Laslow B, Wang D, Merceron C, Giaccia A, Long F, Taylor D, Schipani E., Free PMC Article | 09/30/2024 |
Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1alpha in normoxia. | Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia. Welch N, Mishra S, Bellar A, Kannan P, Gopan A, Goudarzi M, King J, Luknis M, Musich R, Agrawal V, Bena J, Koch CJ, Li L, Willard B, Shah YM, Dasarathy S., | 09/23/2024 |
Hepatic BMAL1 and HIF1alpha regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome. | Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome. Dandavate V, Bolshette N, Van Drunen R, Manella G, Bueno-Levy H, Zerbib M, Kawano I, Golik M, Adamovich Y, Asher G. | 09/12/2024 |
Differential but complementary roles of HIF-1alpha and HIF-2alpha in the regulation of bone homeostasis. | Differential but complementary roles of HIF-1α and HIF-2α in the regulation of bone homeostasis. Lee SY, Kim SJ, Park KH, Lee G, Oh Y, Ryu JH, Huh YH., Free PMC Article | 08/22/2024 |
HIV coinfection exacerbates HBV-induced liver fibrogenesis through a HIF-1alpha- and TGF-beta1-dependent pathway. | HIV coinfection exacerbates HBV-induced liver fibrogenesis through a HIF-1α- and TGF-β1-dependent pathway. Xu M, Warner C, Duan X, Cheng Z, Jeyarajan AJ, Li W, Wang Y, Shao T, Salloum S, Chen PJ, Yu X, Chung RT, Lin W., | 08/22/2024 |
HIF-1alpha limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia. | HIF-1α limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia. Alanova P, Alan L, Opletalova B, Bohuslavova R, Abaffy P, Matejkova K, Holzerova K, Benak D, Kaludercic N, Menabo R, Di Lisa F, Ostadal B, Kolar F, Pavlinkova G. | 08/20/2024 |
Oxygen and HIF1alpha-dependent SDF1 expression in primary astrocytes. | Oxygen and HIF1α-dependent SDF1 expression in primary astrocytes. Pietrucha A, Serdar M, Bendix I, Endesfelder S, Brinke EAD, Urkola A, Bührer C, Schmitz T, Scheuer T. | 08/15/2024 |
Expression of HIF1alpha in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery. | Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery. Lyu P, Wen J, Zhang W, Liu N, Stolzer I, Gießl A, Jia Y, Mauro D, Zhang F, Ciccia F, Soulat D, Günther C, Schett G, Bozec A., Free PMC Article | 08/13/2024 |
Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis. | Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis. Kavaliauskas P, Gu Y, Hasin N, Graf KT, Alqarihi A, Shetty AC, McCracken C, Walsh TJ, Ibrahim AS, Bruno VM., Free PMC Article | 07/9/2024 |
Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection. | Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection. Chen Y, Li X, Wang Z, Yuan S, Shen X, Xie X, Xing K, Zhu Q., Free PMC Article | 07/3/2024 |
MiR-18a affects hypoxia induced glucose metabolism transition in HT22 hippocampal neuronal cell line through the Hif1a gene. | MiR-18a affects hypoxia induced glucose metabolism transition in HT22 hippocampal neuronal cell line through the Hif1a gene. Liu C, Liu G, Zuo X, Qu D, Sun Y, Liu L, Zhao X, Li J, Cai L., Free PMC Article | 07/1/2024 |
The transcription factor HIF-1alpha in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis. | The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis. Nelius E, Fan Z, Sobecki M, Krzywinska E, Nagarajan S, Ferapontova I, Gotthardt D, Takeda N, Sexl V, Stockmann C., Free PMC Article | 06/27/2024 |
HIF-1alpha in cartilage homeostasis, apoptosis, and glycolysis in mice with steroid-induced osteonecrosis of the femoral head. | HIF-1α in cartilage homeostasis, apoptosis, and glycolysis in mice with steroid-induced osteonecrosis of the femoral head. Yu Y, Jiang Y, Ge H, Fan X, Gao H, Zhou Z. | 06/3/2024 |
Single-embryo transcriptomic atlas of oxygen response reveals the critical role of HIF-1alpha in prompting embryonic zygotic genome activation. | Single-embryo transcriptomic atlas of oxygen response reveals the critical role of HIF-1α in prompting embryonic zygotic genome activation. Yao F, Chu M, Xi G, Dai J, Wang Z, Hao J, Yang Q, Wang W, Tang Y, Zhang J, Yue Y, Wang Y, Xu Y, Zhao W, Ma L, Liu J, Zhang Z, Tian J, An L., Free PMC Article | 05/28/2024 |
Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1alpha and nuclear factor erythroid 2-related factor 2. | Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1α and nuclear factor erythroid 2-related factor 2. Ghosh R, Fatahian AN, Rouzbehani OMT, Hathaway MA, Mosleh T, Vinod V, Vowles S, Stephens SL, Chung SD, Cao ID, Jonnavithula A, Symons JD, Boudina S., Free PMC Article | 05/10/2024 |
Granulocytic myeloid-derived suppressor cell activity during biofilm infection is regulated by a glycolysis/HIF1a axis. | Granulocytic myeloid-derived suppressor cell activity during biofilm infection is regulated by a glycolysis/HIF1a axis. Horn CM, Arumugam P, Van Roy Z, Heim CE, Fallet RW, Bertrand BP, Shinde D, Thomas VC, Romanova SG, Bronich TK, Hartman CW, Garvin KL, Kielian T., Free PMC Article | 05/1/2024 |
HIF-1alpha is a "brake" in JNK-mediated activation of amyloid protein precursor and hyperphosphorylation of tau induced by T-2 toxin in BV2 cells. | HIF-1α is a "brake" in JNK-mediated activation of amyloid protein precursor and hyperphosphorylation of tau induced by T-2 toxin in BV2 cells. Zhao Y, Valis M, Wang X, Nepovimova E, Wu Q, Kuca K. | 04/26/2024 |
Mitochondrial dysfunction induced by HIF-1alpha under hypoxia contributes to the development of gastric mucosal lesions. | Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions. Xiao Y, Liu X, Xie K, Luo J, Zhang Y, Huang X, Luo J, Tan S., Free PMC Article | 04/18/2024 |
The DUX4-HIF1alpha Axis in Murine and Human Muscle Cells: A Link More Complex Than Expected. | The DUX4-HIF1α Axis in Murine and Human Muscle Cells: A Link More Complex Than Expected. Nguyen TH, Limpens M, Bouhmidi S, Paprzycki L, Legrand A, Declèves AE, Heher P, Belayew A, Banerji CRS, Zammit PS, Tassin A., Free PMC Article | 04/2/2024 |
Hypoxia inducible factor-1alpha regulates microglial innate immune memory and the pathology of Parkinson's disease. | Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson's disease. Dong H, Zhang X, Duan Y, He Y, Zhao J, Wang Z, Wang J, Li Q, Fan G, Liu Z, Shen C, Zhang Y, Yu M, Fei J, Huang F., Free PMC Article | 04/2/2024 |
Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure. | Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure. Kolesova H, Hrabalova P, Bohuslavova R, Abaffy P, Fabriciova V, Sedmera D, Pavlinkova G., Free PMC Article | 03/22/2024 |
Regulation of genes involved in the metabolic adaptation of murine microglial cells in response to elevated HIF-1alpha mediated activation. | Regulation of genes involved in the metabolic adaptation of murine microglial cells in response to elevated HIF-1α mediated activation. Florance I, Ramasubbu S. | 03/20/2024 |