| FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4. | FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4.
Bian F, Goda C, Wang G, Lan YW, Deng Z, Gao W, Acharya A, Reza AA, Gomez-Arroyo J, Merjaneh N, Ren X, Goveia J, Carmeliet P, Kalinichenko VV, Kalin TV., Free PMC Article | 08/13/2024 |
| Identification of endothelial and mesenchymal FOXF1 enhancers involved in alveolar capillary dysplasia. | Identification of endothelial and mesenchymal FOXF1 enhancers involved in alveolar capillary dysplasia.
Wang G, Wen B, Guo M, Li E, Zhang Y, Whitsett JA, Kalin TV, Kalinichenko VV., Free PMC Article | 07/5/2024 |
| FOXF1 reverses lung fibroblasts transdifferentiation via inhibiting TGF-beta/SMAD2/3 pathway in silica-induced pulmonary fibrosis. | FOXF1 reverses lung fibroblasts transdifferentiation via inhibiting TGF-β/SMAD2/3 pathway in silica-induced pulmonary fibrosis.
Hu B, Zhang X, Fan H, Jin X, Qi Y, Liu R, Li X, Duan M, Zhang C, Li S, Yao W, Hao C. | 06/20/2024 |
| Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension. | Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension.
Isobe S, Nair RV, Kang HY, Wang L, Moonen JR, Shinohara T, Cao A, Taylor S, Otsuki S, Marciano DP, Harper RL, Adil MS, Zhang C, Lago-Docampo M, Körbelin J, Engreitz JM, Snyder MP, Rabinovitch M., Free PMC Article | 03/13/2024 |
| FOXF1 Regulates Alveolar Epithelial Morphogenesis through Transcriptional Activation of Mesenchymal WNT5A. | FOXF1 Regulates Alveolar Epithelial Morphogenesis through Transcriptional Activation of Mesenchymal WNT5A.
Reza AA, Kohram F, Reza HA, Kalin TR, Kannan PS, Zacharias WJ, Kalinichenko VV., Free PMC Article | 04/6/2023 |
| The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFbeta signaling pathways to drive tongue organogenesis. | The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis.
Xu J, Liu H, Lan Y, Jiang R., Free PMC Article | 01/28/2023 |
| Transcription factor FOXF1 identifies compartmentally distinct mesenchymal cells with a role in lung allograft fibrogenesis. | Transcription factor FOXF1 identifies compartmentally distinct mesenchymal cells with a role in lung allograft fibrogenesis.
Braeuer RR, Walker NM, Misumi K, Mazzoni-Putman S, Aoki Y, Liao R, Vittal R, Kleer GG, Wheeler DS, Sexton JZ, Farver CF, Welch JD, Lama VN., Free PMC Article | 12/11/2021 |
| FOXF1 mutations identified in 28 subjects with ACDMPV. Foxf1WT/S52F knock-in mice recapitulated histopathologic findings in ACDMPV infants. The S52F FOXF1 mutation disrupted STAT3-FOXF1 protein-protein interactions and inhibited transcription of Stat3 STAT3 signaling and endothelial proliferation were reduced in Foxf1WT/S52F mice and human ACDMPV lungs. | The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia.
Pradhan A, Dunn A, Ustiyan V, Bolte C, Wang G, Whitsett JA, Zhang Y, Porollo A, Hu YC, Xiao R, Szafranski P, Shi D, Stankiewicz P, Kalin TV, Kalinichenko VV., Free PMC Article | 05/23/2020 |
| Knockout of Foxf1 and Foxf2 together, but not alone, from mouse smooth muscle resulted in delayed liquid gastric emptying | Gastroparesis is associated with decreased FOXF1 and FOXF2 in humans, and loss of FOXF1 and FOXF2 results in gastroparesis in mice.
Herring BP, Hoggatt AM, Gupta A, Wo JM., Free PMC Article | 01/25/2020 |
| FOXF1 deletion increases myofibroblast invasion and collagen secretion and promotes a switch from N-cadherin (CDH2) to Cadherin-11 (CDH11), which is a critical step in the acquisition of the pro-fibrotic phenotype. FOXF1 directly binds to Cdh2 and Cdh11 promoters and differentially regulates transcription of these genes. | FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts.
Black M, Milewski D, Le T, Ren X, Xu Y, Kalinichenko VV, Kalin TV., Free PMC Article | 09/21/2019 |
| Thus FOXF1 stimulates lung regeneration following partial pneumonectomy via direct transcriptional regulation of genes critical for extracellular matrix remodeling and cell cycle progression. | FOXF1 transcription factor promotes lung regeneration after partial pneumonectomy.
Bolte C, Flood HM, Ren X, Jagannathan S, Barski A, Kalin TV, Kalinichenko VV., Free PMC Article | 05/25/2019 |
| It is concluded that during early pseudoglandular stage of lung development Ptch1 patterns Fgf10 and regulates Foxf1 expression in the lung mesenchyme to direct branch formation and this is essential for proper lobe formation and lung function. | Patched1 patterns Fibroblast growth factor 10 and Forkhead box F1 expression during pulmonary branch formation.
Ho UY, Wainwright BJ. | 06/16/2018 |
| FOXF1 promotes prostate tumor growth and progression by activating ERK5 signaling | The transcription factor FOXF1 promotes prostate cancer by stimulating the mitogen-activated protein kinase ERK5.
Fulford L, Milewski D, Ustiyan V, Ravishankar N, Cai Y, Le T, Masineni S, Kasper S, Aronow B, Kalinichenko VV, Kalin TV. | 12/2/2017 |
| Expression of Bmp4 in the ureteric mesenchyme depends on HH signaling and Foxf1, and that exogenous BMP4 rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 function. | A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development.
Bohnenpoll T, Wittern AB, Mamo TM, Weiss AC, Rudat C, Kleppa MJ, Schuster-Gossler K, Wojahn I, Lüdtke TH, Trowe MO, Kispert A., Free PMC Article | 09/16/2017 |
| The Gli increased the activity of one of these long-range enhancers, which was specific to distal blood vessel, suggesting that Shh regulates Foxf1 transcription in pulmonary distal blood vessel formation. | Long-range enhancers modulate Foxf1 transcription in blood vessels of pulmonary vascular network.
Seo H, Kim J, Park GH, Kim Y, Cho SW. | 06/10/2017 |
| Data indicate that forkhead box F1 (Foxf1) deletion from endothelial cells decreases the abundance of sphingosine 1-phosphate receptor 1 (S1PR1). | FOXF1 maintains endothelial barrier function and prevents edema after lung injury.
Cai Y, Bolte C, Le T, Goda C, Xu Y, Kalin TV, Kalinichenko VV. | 01/14/2017 |
| Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association | Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association.
Hilger AC, Halbritter J, Pennimpede T, van der Ven A, Sarma G, Braun DA, Porath JD, Kohl S, Hwang DY, Dworschak GC, Hermann BG, Pavlova A, El-Maarri O, Nöthen MM, Ludwig M, Reutter H, Hildebrandt F., Free PMC Article | 08/20/2016 |
| novel Shh-Foxf-Fgf18-Shh circuit in the palate development molecular network, in which Foxf1 and Foxf2 regulate palatal shelf growth downstream of Shh signaling, at least in part, by repressing Fgf18 expression | A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development.
Xu J, Liu H, Lan Y, Aronow BJ, Kalinichenko VV, Jiang R., Free PMC Article | 05/14/2016 |
| findings suggest that Foxf1 may serve as a target gene to disrupt progression of liver fibrosis and DBTC might provide a potentially feasible and effective tool for HSC-specific delivery of therapeutic RNA | Foxf1 siRNA delivery to hepatic stellate cells by DBTC lipoplex formulations ameliorates fibrosis in livers of bile duct ligated mice.
Abshagen K, Brensel M, Genz B, Roth K, Thomas M, Fehring V, Schaeper U, Vollmar B. | 01/16/2016 |
| Our findings implicate Foxf genes(Foxf1a and Foxf2 ) in atrioventricular septation, describe the molecular underpinnings of the genetic interaction between Hedgehog signaling and Tbx5 | Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP., Free PMC Article | 07/4/2015 |
| Data indicate FOXF1 transcription factor is required for the formation of embryonic vasculature by regulating endothelial genes critical for vascular development and vascular endothelial growth factor signaling. | FOXF1 transcription factor is required for formation of embryonic vasculature by regulating VEGF signaling in endothelial cells.
Ren X, Ustiyan V, Pradhan A, Cai Y, Havrilak JA, Bolte CS, Shannon JM, Kalin TV, Kalinichenko VV., Free PMC Article | 12/20/2014 |
| Endodermal Shh and mesenchymal Foxf1 genes expression were preserved around the hindgut cystic malformation. | Effect of abnormal notochord delamination on hindgut development in the Adriamycin mouse model.
Sato H, Hajduk P, Furuta S, Wakisaka M, Murphy P, Puri P, Kitagawa H. | 06/21/2014 |
| Foxf1 also directly binds to serum response factor (SRF) and myocardin-related transcription factors (MRTFs). | The transcription factor Foxf1 binds to serum response factor and myocardin to regulate gene transcription in visceral smooth muscle cells.
Hoggatt AM, Kim JR, Ustiyan V, Ren X, Kalin TV, Kalinichenko VV, Herring BP., Free PMC Article | 12/7/2013 |
| Observations suggest that hedgehog-dependent FoxF1 is a clinically relevant lung CAF-inducing factor, and support experimentally the general concept that CAF properties can be induced by activation of developmentally important transcription factors. | Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.
Saito RA, Micke P, Paulsson J, Augsten M, Peña C, Jönsson P, Botling J, Edlund K, Johansson L, Carlsson P, Jirström K, Miyazono K, Ostman A. | 05/10/2010 |
| study suggests that Foxf1 expression is characteristically up-regulated in tumors with a constitutively activated Hedgehog signaling pathway thereby defining a key role for Foxf1 in Hedgehog-associated tumorigenesis | Characteristic overexpression of the forkhead box transcription factor Foxf1 in Patched-associated tumors.
Wendling DS, Lück C, von Schweinitz D, Kappler R. | 01/21/2010 |