| SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis. | SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis.
Ren R, Ding S, Ma K, Jiang Y, Wang Y, Chen J, Wang Y, Kou Y, Fan X, Zhu X, Qin L, Qiu C, Simons M, Wei X, Yu L., | 02/1/2024 |
| HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice. | HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice.
Tanaka M, Homme M, Teramura Y, Kumegawa K, Yamazaki Y, Yamashita K, Osato M, Maruyama R, Nakamura T., Free PMC Article | 05/30/2023 |
| Babam2 negatively regulates osteoclastogenesis by interacting with Hey1 to inhibit Nfatc1 transcription. | Babam2 negatively regulates osteoclastogenesis by interacting with Hey1 to inhibit Nfatc1 transcription.
Jin F, Zhu Y, Liu M, Wang R, Cui Y, Wu Y, Liu G, Wang Y, Wang X, Ren Z., Free PMC Article | 07/30/2022 |
| Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription. | Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription.
Watanabe Y, Seya D, Ihara D, Ishii S, Uemoto T, Kubo A, Arai Y, Isomoto Y, Nakano A, Abe T, Shigeta M, Kawamura T, Saito Y, Ogura T, Nakagawa O., Free PMC Article | 04/3/2021 |
| BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction. | BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction.
Kusuyama J, Seong C, Nakamura T, Ohnishi T, Amir MS, Shima K, Semba I, Noguchi K, Matsuguchi T. | 03/21/2020 |
| HeyL and Hey1 function redundantly in muscle stem cells, and HeyL requires Hes1 for effective DNA binding and biological activity | Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.
Noguchi YT, Nakamura M, Hino N, Nogami J, Tsuji S, Sato T, Zhang L, Tsujikawa K, Tanaka T, Izawa K, Okada Y, Doi T, Kokubo H, Harada A, Uezumi A, Gessler M, Ohkawa Y, Fukada SI. | 01/4/2020 |
| our findings suggested that CCN3 significantly inhibited the osteogenic differentiation of mouse embryonic fibroblasts. The inhibitory effect of CCN3 was mainly through the inhibition of BMP signaling and the mutual inhibition with DLL1, so as to inhibit the expression of Hey1, the target gene shared by BMP and Notch signaling pathways. | CCN3 and DLL1 co-regulate osteogenic differentiation of mouse embryonic fibroblasts in a Hey1-dependent manner.
Su X, Wei Y, Cao J, Wu X, Mou D, Luo J, Li A, Zuo GW, Tang M., Free PMC Article | 12/14/2019 |
| Data implied that Hey2 function is restricted to transient amplifying cells of the ameloblast cell lineage and that Hey1 plays a role in the composition of the subodontoblastic layer, in addition to ameloblast differentiation. | Hey1 and Hey2 are differently expressed during mouse tooth development.
Kibe K, Nakatomi M, Kataoka S, Toyono T, Seta Y. | 07/28/2018 |
| stable Hey1overexpressing cells expressed higher levels of dentin sialophosphoprotein (DSPP) and exhibited higher mineralization capabilities following stimulation by differentiation medium. Furthermore, RNA interferencemediated knockdown of Hey1 downregulated the expression levels of DSPP in OLCs stimulated by differentiation medium. | Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells.
Yin X, Zeng Z, Xing J, Zhang A, Jiang W, Wang W, Sun H, Ni L., Free PMC Article | 07/14/2018 |
| A Jagged1-Hey1 signal might mediate the impairment of angiogenesis induced by Ang II during cardiac hypertrophy. | Role of Jagged1-Hey1 Signal in Angiotensin II-induced Impairment of Myocardial Angiogenesis.
Guan AL, He T, Shao YB, Chi YF, Dai HY, Wang Y, Xu L, Yang X, Ding HM, Cai SL., Free PMC Article | 03/25/2017 |
| Cyclic stretch enhanced the BMP-2induced osteoblastic differentiation through the inhibition of Hey1. | Cyclic stretch enhances bone morphogenetic protein-2-induced osteoblastic differentiation through the inhibition of Hey1.
Zeng Z, Yin X, Zhang X, Jing D, Feng X., Free PMC Article | 09/10/2016 |
| Hes/Hey signaling at the Atoh1 promoter has a role in selection of cell fate in the organ of Corti | Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter.
Abdolazimi Y, Stojanova Z, Segil N., Free PMC Article | 08/6/2016 |
| These in vitro and in vivo data support an anti-adipogenic role of COUP-TFII via downregulating the Notch signaling target gene Hey1. | The Anti-Adipogenic Potential of COUP-TFII Is Mediated by Downregulation of the Notch Target Gene Hey1.
Scroyen I, Bauters D, Vranckx C, Lijnen HR., Free PMC Article | 07/2/2016 |
| Hey proteins mechanistically repress target genes via histone deacetylase recruitment and histone deacetylation. | Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes.
Weber D, Heisig J, Kneitz S, Wolf E, Eilers M, Gessler M. | 09/26/2015 |
| Hey1 and Hey2 in endothelial cells play important roles in vascular development. | An important role of endothelial hairy-related transcription factors in mouse vascular development.
Morioka T, Sakabe M, Ioka T, Iguchi T, Mizuta K, Hattammaru M, Sakai C, Itoh M, Sato GE, Hashimoto A, Fujita M, Okumura K, Araki M, Xin M, Pedersen RA, Utset MF, Kimura H, Nakagawa O. | 07/25/2015 |
| findings indicate that Hey1 and Hey2 control the spatial and temporal pattern of auditory HC differentiation. | Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling.
Benito-Gonzalez A, Doetzlhofer A., Free PMC Article | 11/22/2014 |
| This study demonistrated that demonstrates that the lack of Hesr1 leads to an alteration in sensitivity to dopamine accompanied by enhanced prepulse inhibition. | Enhanced prepulse inhibition and low sensitivity to a dopamine agonist in HESR1 knockout mice.
Kanno K, Kokubo H, Takahashi A, Koide T, Ishiura S. | 09/13/2014 |
| A muscle-specific regulatory element of p57(kip2) directly activated by muscle regulatory factors in myoblasts but repressed by the Notch targets Hes1/Hey1 in progenitor cells, is identified. | Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest.
Zalc A, Hayashi S, Auradé F, Bröhl D, Chang T, Mademtzoglou D, Mourikis P, Yao Z, Cao Y, Birchmeier C, Relaix F. | 09/6/2014 |
| Notch-RBPjk signaling functions in part through Hey1-mediated inhibition of NFATc1 to suppress osteoblastogenesis, contributing to bone homeostasis in vivo | Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.
Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F., Free PMC Article | 09/8/2012 |
| These results indicate that Hesr1 and Hesr3 are essential for the generation of adult satellite cells and for the maintenance of skeletal muscle homeostasis. | Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.
Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H., Free PMC Article | 12/31/2011 |
| Hes1, Hes5 and Hey1 cooperatively inhibit hair cell formation, and one allele of Hes1, Hes5 or Hey1 is sufficient for supporting cell production probably by lateral inhibition in the sensory epithelium. | Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.
Tateya T, Imayoshi I, Tateya I, Ito J, Kageyama R. | 05/28/2011 |
| Hey1 inhibits myogenesis by associating with and repressing expression of key myogenic targets. | The Notch effector Hey1 associates with myogenic target genes to repress myogenesis.
Buas MF, Kabak S, Kadesch T., Free PMC Article | 02/1/2010 |
| Notch1, rather than Notch3, mediates SMC proliferation and neointimal formation after vascular injury through hey1 | Smooth muscle Notch1 mediates neointimal formation after vascular injury.
Li Y, Takeshita K, Liu PY, Satoh M, Oyama N, Mukai Y, Chin MT, Krebs L, Kotlikoff MI, Radtke F, Gridley T, Liao JK., Free PMC Article | 01/21/2010 |
| Hey1 and Runx2 were shown to act synergistically in BMP9-induced osteogenic differentiation, and Runx2 expression significantly decreased in the absence of Hey1, suggesting that Runx2 may function downstream of Hey1 | Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.
Sharff KA, Song WX, Luo X, Tang N, Luo J, Chen J, Bi Y, He BC, Huang J, Li X, Jiang W, Zhu GH, Su Y, He Y, Shen J, Wang Y, Chen L, Zuo GW, Liu B, Pan X, Reid RR, Luu HH, Haydon RC, He TC., Free PMC Article | 01/21/2010 |
| Hesr1 and Hesr2 are the downstream mediators of the prosensory function of Notch in early cochlear development. | Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.
Hayashi T, Kokubo H, Hartman BH, Ray CA, Reh TA, Bermingham-McDonogh O., Free PMC Article | 01/21/2010 |