| our data provide evidence for a novel role of Hesx1 in the control of self-renewal and maintenance of the undifferentiated state in ESCs and mouse embryos. | Genetic Deletion of Hesx1 Promotes Exit from the Pluripotent State and Impairs Developmental Diapause.
Pozzi S, Bowling S, Apps J, Brickman JM, Rodriguez TA, Martinez-Barbera JP., Free PMC Article | 07/4/2020 |
| Hesx1 plays a significant role in sustaining pluripotency in embryonic stem cells.Hesx1 transcriptionally suppresses differentiation-related genes. | Hesx1 enhances pluripotency by working downstream of multiple pluripotency-associated signaling pathways.
Li WZ, Wang ZW, Chen LL, Xue HN, Chen X, Guo ZK, Zhang Y. | 11/14/2015 |
| Wnt inhibition during the first day has larger impact on the activation of Hesx1 and Six3, suggesting that in embryos Wnt inhibition caused by Dkk1 contributes greatly in the establishment of the anterior forebrain precursor. | Dkk1-dependent inhibition of Wnt signaling activates Hesx1 expression through its 5' enhancer and directs forebrain precursor development.
Matsuda K, Kondoh H. | 11/8/2014 |
| Variability in Hes1 expression therefore helps to explain why STAT3 responsiveness varies between individual ES cells, and this in turn helps to explain why pluripotent cells commit to differentiate asynchronously.. | Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity.
Zhou X, Smith AJ, Waterhouse A, Blin G, Malaguti M, Lin CY, Osorno R, Chambers I, Lowell S., Free PMC Article | 06/21/2014 |
| Transcriptional profiling of anterior forebrain precursors from mouse embryos expressing eGFP from the Hesx1 locus provides molecular evidence supporting a novel function of Hesx1 in mediating repression of Wnt/beta-catenin target activation. | HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.
Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP., Free PMC Article | 12/24/2011 |
| Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1. | Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.
Carvalho LR, Brinkmeier ML, Castinetti F, Ellsworth BS, Camper SA., Free PMC Article | 07/19/2010 |
| Data suggest that formation of a heterodimer between HESX1 and PROP1 allows HESX1 to become active, and that PROP1 then replaces HESX1 to advance to the middle stage of pituitary development. | Pituitary homeodomain transcription factors HESX1 and PROP1 form a heterodimer on the inverted TAAT motif.
Kato Y, Kimoto F, Susa T, Nakayama M, Ishikawa A, Kato T. | 07/12/2010 |
| Hesx1(I26T/I26T) embryos show pituitary defects comparable with Hesx1(-/-) mouse mutants, with frequent occurrence of ocular abnormalities, although the telencephalon develops normally | Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism.
Sajedi E, Gaston-Massuet C, Signore M, Andoniadou CL, Kelberman D, Castro S, Etchevers HC, Gerrelli D, Dattani MT, Martinez-Barbera JP., Free PMC Article | 01/21/2010 |
| Haploinsufficiency of both Six3 and Hesx1 leads to severe pituitary dysmorphogenesis during development, which results in hypopituitarism with dramatic postnatal growth retardation. | Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.
Gaston-Massuet C, Andoniadou CL, Signore M, Sajedi E, Bird S, Turner JM, Martinez-Barbera JP., Free PMC Article | 01/21/2010 |
| establish a link between HESX1 and DNMT1 and suggest a novel mechanism for the repressing properties of HESX1 | DNMT1 interacts with the developmental transcriptional repressor HESX1.
Sajedi E, Gaston-Massuet C, Andoniadou CL, Signore M, Hurd PJ, Dattani M, Martinez-Barbera JP., Free PMC Article | 01/21/2010 |
| A novel inducible element, activated by contact with Rathke's pouch, is present in the regulatory region of the Hesx1 homeobox gene. | A novel inducible element, activated by contact with Rathke's pouch, is present in the regulatory region of the Rpx/Hesx1 homeobox gene.
Hermesz E, Williams-Simons L, Mahon KA. | 01/21/2010 |
| the domains of Hes-1 needed to block adipogenesis coincide with those necessary for transcriptional repression. | Functional analysis of Hes-1 in preadipocytes.
Ross DA, Hannenhalli S, Tobias JW, Cooch N, Shiekhattar R, Kadesch T. | 01/21/2010 |
| Conserved regulatory elements establish the dynamic expression of Rpx in early development. | Conserved regulatory elements establish the dynamic expression of Rpx/HesxI in early vertebrate development.
Chou SJ, Hermesz E, Hatta T, Feltner D, El-Hodiri HM, Jamrich M, Mahon K. | 01/21/2010 |
| The absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development. | Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain.
Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M, Martinez-Barbera JP., Free PMC Article | 01/21/2010 |