| The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis. | The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis.
Li Y, Gao J, Zhao D, Guan X, Morris SC, Finkelman FD, Huang H., Free PMC Article | 07/10/2023 |
| Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine. | Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine.
Rani B, Silva-Marques B, Leurs R, Passani MB, Blandina P, Provensi G., Free PMC Article | 09/18/2021 |
| Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune Encephalomyelitis. | Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune Encephalomyelitis.
Morin F, Singh N, Mdzomba JB, Dumas A, Pernet V, Vallières L. | 09/4/2021 |
| Analysis of Immune Associated Co-Expression Networks Reveals Immune-Related Long Non-Coding RNAs during MI in the Presence and Absence of HDC. | Analysis of Immune Associated Co-Expression Networks Reveals Immune-Related Long Non-Coding RNAs during MI in the Presence and Absence of HDC.
Zhang Z, Ding S, Yang X, Ge J., Free PMC Article | 08/14/2021 |
| Changes in histidine decarboxylase expression influence extramedullary hematopoiesis in postnatal mice. | Changes in histidine decarboxylase expression influence extramedullary hematopoiesis in postnatal mice.
Otsuka H, Endo Y, Ohtsu H, Inoue S, Kuraoka M, Koh M, Yagi H, Nakamura M, Soeta S. | 07/17/2021 |
| Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments. | Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments.
Otsuka H, Endo Y, Ohtsu H, Inoue S, Noguchi S, Nakamura M, Soeta S. | 06/12/2021 |
| Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling. | Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling.
Kennedy L, Meadows V, Demieville J, Hargrove L, Virani S, Glaser S, Zhou T, Rinehart E, Jaeger V, Kyritsi K, Pham L, Alpini G, Francis H., Free PMC Article | 10/24/2020 |
| Hdc mutant mice show abnormal behavior, striatal dopamine turnover and opioid peptide gene expression. | Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice.
Abdurakhmanova S, Semenova S, Piepponen TP, Panula P. | 03/14/2020 |
| Hdc(-/-) high-fat diet (HFD) mice had increased steatosis compared with WT HFD mice. WT HFD mice had increased biliary mass, biliary proliferation, senescence, fibrosis, and hepatic stellate cell activation, which were reduced in Hdc(-/-) HFD mice. In Hdc(-/-) HFD mice, serum leptin levels increased, whereas biliary Ob-R expression decreased. | Knockout of l-Histidine Decarboxylase Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling.
Kennedy L, Hargrove L, Demieville J, Bailey JM, Dar W, Polireddy K, Chen Q, Nevah Rubin MI, Sybenga A, DeMorrow S, Meng F, Stockton L, Alpini G, Francis H., Free PMC Article | 04/13/2019 |
| The results of this study indicated that Hdc deficiency in mice does not disturb the development of striatal and cortical interneurons and does not lead to the morphological and cytological phenotypes characterized by humans with Guilles de la Tourette syndrome. | Behavioral and stereological characterization of Hdc KO mice: Relation to Tourette syndrome.
Abdurakhmanova S, Chary K, Kettunen M, Sierra A, Panula P. | 05/26/2018 |
| Genetic abnormalities in histaminergic signaling may produce a vulnerability to inflammatory challenge, setting the state for pathogenically dysregulated neuroimmune responses. | Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation.
Frick L, Rapanelli M, Abbasi E, Ohtsu H, Pittenger C., Free PMC Article | 01/13/2018 |
| The H3 receptor is upregulated in the striatum in the Hdc KO mouse model of tic disorders. | Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders.
Rapanelli M, Frick L, Pogorelov V, Ohtsu H, Bito H, Pittenger C., Free PMC Article | 11/18/2017 |
| Lack of endogenous histamine in NOD HDC(-/-) mice decreased the incidence of diabetes in relation to their wild-type counterpart. | Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice.
Alkan M, Machavoine F, Rignault R, Dam J, Dy M, Thieblemont N., Free PMC Article | 03/12/2016 |
| the structure and function of the retina in mice that lacked expression of the rate limiting enzyme in the formation of histamine, histidine decarboxylase (Hdc-/- mouse), were investigated. | The role of histamine in the retina: studies on the Hdc knockout mouse.
Greferath U, Vessey KA, Jobling AI, Mills SA, Bui BV, He Z, Nag N, Ohtsu H, Fletcher EL., Free PMC Article | 09/12/2015 |
| SDS induces itch through increased production of epidermal histamine, which results from an increase in the gene expression and post-translation processing of L-histidine decarboxylase. | Surfactant-induced chronic pruritus: Role of L-histidine decarboxylase expression and histamine production in epidermis.
Inami Y, Sasaki A, Andoh T, Kuraishi Y. | 07/25/2015 |
| HDC, whose expression is remarkably downregulated during the first few days after birth in dermal cells of mice, plays essential roles in the hair-inducing ability of newborn mouse dermal cells | Histidine decarboxylase expression influences the neofolliculogenesis of newborn mouse dermal cells.
Na JI, Nam KM, Choi HR, Inui S, Youn SW, Huh CH, Park KC. | 12/8/2012 |
| An increased expression of H3 receptors in HDC KO mice without any changes in the spontaneous firing of "histaminergic" neurons without histamine and their responses to the H3 receptor agonist (R)-alpha-methylhistamine. | Histamine receptor expression, hippocampal plasticity and ammonia in histidine decarboxylase knockout mice.
Chepkova A, Yanovsky E, Parmentier R, Ohtsu H, Haas HL, Lin JS, Sergeeva OA. | 05/19/2012 |
| Histidine decarboxylase was found at comparably high levels in mouse striatum. | High levels of histidine decarboxylase in the striatum of mice and rats.
Krusong K, Ercan-Sencicek AG, Xu M, Ohtsu H, Anderson GM, State MW, Pittenger C., Free PMC Article | 08/20/2011 |
| There was no difference in the levels of vascular endothelial growth factor between HDC-/- or wild-type mice, either in the lung or in bronchoalveolar-lavage cells. | Increased synthesis of vascular endothelial growth factor in allergic airway inflammation in histidine decarboxylase knockout (HDC(-/-)) mice.
Sziksz E, Tibor Kozma G, Komlósi ZI, Pállinger E, Kardos M, Szebeni B, Losonczy G, Falus A, Szabó A, Tulassay T, Vannay A. | 12/4/2010 |
| The absence of histamine adversely affects splenic hematopoiesis via direct and indirect mechanisms | Extramedullary hematopoiesis is dysregulated in histamine-free histidine decarboxylase knockout (HDC-/-) mice.
Horváth Z, Pállinger E, Horváth G, Jelinek I, Veszely G, Furész J, Falus A, Buzás EI. | 08/9/2010 |
| HDC-/- mice showed reduced severity of K/BxN serum-induced arthritis. | Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis.
Rajasekaran N, Solomon S, Watanabe T, Ohtsu H, Gajda M, Bräuer R, Illges H. | 01/21/2010 |
| Histidine-decarboxylase (a histamine synthesizing enzyme) knock-out mice displayed sleep fragmentation and increased paradoxical sleep compared to wild-type mice. | Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models.
Anaclet C, Parmentier R, Ouk K, Guidon G, Buda C, Sastre JP, Akaoka H, Sergeeva OA, Yanagisawa M, Ohtsu H, Franco P, Haas HL, Lin JS., Free PMC Article | 01/21/2010 |
| Knock-out of the histidine decarboxylase gene causes a general endocrine imbalance in the hormones which are related to histamine, namely ACTH, triiodothyronine and endorphin inside the immune cells. | Histidine decarboxylase (HDC) knock out mouse immune cells have altered expression of ACTH, triiodothyronine and endorphin.
Csaba G, Kovács P, Buzás E, Mazán M, Pállinger E. | 01/21/2010 |
| This study provide evidence that formalin-evoked painful stimulus elicits rapid alterations in the activity of neuroglial elements of histidine decarboxylase-deficient mice that are involved in the communication between brain and csf space. | Highly activated c-fos expression in specific brain regions (ependyma, circumventricular organs, choroid plexus) of histidine decarboxylase deficient mice in response to formalin-induced acute pain.
Palkovits M, Deli MA, Gallatz K, Tóth ZE, Buzás E, Falus A. | 01/21/2010 |
| HDC-KO mice exhibited improved contextual fear from 1 day after training and this lasted for at least 14 days when compared with the wild-type (WT) controls. | Improved learning and memory of contextual fear conditioning and hippocampal CA1 long-term potentiation in histidine decarboxylase knock-out mice.
Liu L, Zhang S, Zhu Y, Fu Q, Zhu Y, Gong Y, Ohtsu H, Luo J, Wei E, Chen Z. | 01/21/2010 |