| Hippocampal HDAC5-mediated histone acetylation underlies stress susceptibility in mice exposed to chronic social defeat stress. | Hippocampal HDAC5-mediated histone acetylation underlies stress susceptibility in mice exposed to chronic social defeat stress.
Li N, Liu T, Wang YY, Xu T, Shi HJ, Chang L, Zhu LJ. | 09/5/2024 |
| SNHG16/miR-205/HDAC5 is involved in the progression of renal fibrosis. | SNHG16/miR-205/HDAC5 is involved in the progression of renal fibrosis.
Zhao Y, Wang H, Tang Y, Wang J, Wu X, He Z, He Y, Tang Z. | 01/26/2024 |
| HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction. | HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction.
Zhu C, Piao Z, Jin L., Free PMC Article | 09/27/2023 |
| HDAC5-Mediated Acetylation of p100 Suppresses Its Processing. | HDAC5-Mediated Acetylation of p100 Suppresses Its Processing.
Wang J, Wu S, Liu L, Pang Y, Li Z, Mu H., Free PMC Article | 06/23/2023 |
| Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin-proteasome system in skeletal muscle. | Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin-proteasome system in skeletal muscle.
Huang S, Zheng X, Zhang X, Jin Z, Liu S, Fu L, Niu Y. | 11/19/2022 |
| HDAC5 RNA interference ameliorates acute renal injury by upregulating KLF2 and inhibiting NALP3 expression in a mouse model of oxalate nephropathy. | HDAC5 RNA interference ameliorates acute renal injury by upregulating KLF2 and inhibiting NALP3 expression in a mouse model of oxalate nephropathy.
Sharma P, Karnam K, Mahale A, Sedmaki K, Krishna Venuganti V, Kulkarni OP. | 10/29/2022 |
| Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-kappaB signaling. | Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-κB signaling.
Xu C, Tang J, Yang Q, Zhao H, Liu Y, Cao J, Zhou Y, Chen X, Chen J., Free PMC Article | 01/29/2022 |
| Cyclic AMP represses pathological MEF2 activation by myocyte-specific hypo-phosphorylation of HDAC5. | Cyclic AMP represses pathological MEF2 activation by myocyte-specific hypo-phosphorylation of HDAC5.
He T, Huang J, Chen L, Han G, Stanmore D, Krebs-Haupenthal J, Avkiran M, Hagenmüller M, Backs J. | 08/14/2021 |
| HDAC5 promotes intestinal sepsis via the Ghrelin/E2F1/NF-kappaB axis. | HDAC5 promotes intestinal sepsis via the Ghrelin/E2F1/NF-κB axis.
Li B, Zhang L, Zhu L, Cao Y, Dou Z, Yu Q. | 07/24/2021 |
| miR-485 inhibits histone deacetylase HDAC5, HIF1alpha and PFKFB3 expression to alleviate epilepsy in cellular and rodent models. | miR-485 inhibits histone deacetylase HDAC5, HIF1α and PFKFB3 expression to alleviate epilepsy in cellular and rodent models.
Pan W, Song X, Hu Q, Zhang Y., Free PMC Article | 07/24/2021 |
| The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKalpha2. | The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2.
Lee JO, Byun WS, Kang MJ, Han JA, Moon J, Shin MJ, Lee HJ, Chung JH, Lee JS, Son CG, Song KH, Kim TW, Lee ES, Kim HM, Chung CH, Ngoei KRW, Ling NXY, Oakhill JS, Galic S, Murray-Segal L, Kemp BE, Kim KM, Lim S, Kim HS., Free PMC Article | 04/24/2021 |
| A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. | A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.
Sato T, Verma S, Andrade CDC, Omeara M, Campbell N, Wang JS, Cetinbas M, Lang A, Ausk BJ, Brooks DJ, Sadreyev RI, Kronenberg HM, Lagares D, Uda Y, Pajevic PD, Bouxsein ML, Gross TS, Wein MN., Free PMC Article | 09/5/2020 |
| Susceptible mice showed a selective reduction of the g9a mRNA levels in the hippocampus, while HDAC-5 and DNMT3a mRNA levels were specifically reduced in the prefrontal cortex. | Chronic social defeat stress differentially regulates the expression of BDNF transcripts and epigenetic modifying enzymes in susceptible and resilient mice.
Mallei A, Ieraci A, Popoli M. | 08/12/2020 |
| PTHrP inhibits chondrocyte hypertrophy and subsequent bone formation in vivo by allowing HDAC4 and HDAC5 to block the Mef2/Runx2 signaling cascade. | PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy.
Nishimori S, Lai F, Shiraishi M, Kobayashi T, Kozhemyakina E, Yao TP, Lassar AB, Kronenberg HM., Free PMC Article | 06/6/2020 |
| It identified HDAC5 as a novel mediator of hepatic fatty acid oxidation by fasting and ER stress signals, and strategies to promote HDAC5 dephosphorylation could serve as new tools for the treatment of obesity-associated hepatic steatosis. | HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation.
Qiu X, Li J, Lv S, Yu J, Jiang J, Yao J, Xiao Y, Xu B, He H, Guo F, Zhang ZN, Zhang C, Luan B., Free PMC Article | 07/20/2019 |
| Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKalpha2-dependent manner. | Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.
Niu Y, Wang T, Liu S, Yuan H, Li H, Fu L. | 12/1/2018 |
| Hdac5 and Hdac6 expression are required for the adequate expression of Icer and adipocyte function. Altered adipose expression of the two Hdacs in obesity by hypoxia may contribute to the development of metabolic abnormalities. | Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function.
Bricambert J, Favre D, Brajkovic S, Bonnefond A, Boutry R, Salvi R, Plaisance V, Chikri M, Chinetti-Gbaguidi G, Staels B, Giusti V, Caiazzo R, Pattou F, Waeber G, Froguel P, Abderrahmani A., Free PMC Article | 09/8/2018 |
| class IIa HDAC function could be used to enhance metabolic health in chronic diseases driven by physical inactivity. | Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.
Gaur V, Connor T, Sanigorski A, Martin SD, Bruce CR, Henstridge DC, Bond ST, McEwen KA, Kerr-Bayles L, Ashton TD, Fleming C, Wu M, Pike Winer LS, Chen D, Hudson GM, Schwabe JWR, Baar K, Febbraio MA, Gregorevic P, Pfeffer FM, Walder KR, Hargreaves M, McGee SL. | 11/18/2017 |
| HDAC5 emerges as a cellular conductor of MEF2C and M6a activity and is regulated by miR-124 and miR-9 to control neurite development. | miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway.
Gu X, Fu C, Lin L, Liu S, Su X, Li A, Wu Q, Jia C, Zhang P, Chen L, Zhu X, Wang X. | 10/28/2017 |
| This paper presents data for the first time directly supporting the role of HDAC5 as a scaffold recruiting a chromatin modifying co-repressor complex to specific transcription factors on unique gene promoters. These data for HDAC5 may reflect one of the functions of class IIa HDACs in transcriptional regulation distinct from its catalytic activity. | Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes.
Harris LG, Wang SH, Mani SK, Kasiganesan H, Chou CJ, Menick DR., Free PMC Article | 07/8/2017 |
| This study demonstrated that decreased HDAC5 function is able to exacerbate the long-term behavioral effects of adverse rearing environment in mice | Histone deacetylase 5 modulates the effects of social adversity in early life on cocaine-induced behavior.
Valzania A, Catale C, Viscomi MT, Puglisi-Allegra S, Carola V. | 07/1/2017 |
| As HDAC5 expression may help nullify AIS and identify progenitor cells, the precise delivery of miD2861 may serve as a vehicle for monitoring network remodeling with target specificity and signal sensitivity after drug exposure that identifies brain repair processes in adult animals. | Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling.
Liu PK, Liu CH., Free PMC Article | 03/11/2017 |
| HDAC5 inhibits hepatic lipogenic genes expression by attenuating the transcriptional activity of liver X receptor. | HDAC5 Inhibits Hepatic Lipogenic Genes Expression by Attenuating the Transcriptional Activity of Liver X Receptor.
Jia HY, Li QZ, Lv LF. | 02/4/2017 |
| This study demonstrated that mice with learned helplessness protocol-induced behavioral despair exhibited higher levels of HDAC5 and HDAC5 binding to the promoter region of BDNF exon IV resulting in the decreased expression of BDNF. | Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression.
Su CL, Su CW, Hsiao YH, Gean PW. | 12/17/2016 |
| inhibition of HDAC5 differentially regulates ghrelin and NUCB2/ nesfatin-1 expression by enhancing the acetylation and phosphorylation of Raptor, which subsequently suppress mTORC1 signaling | HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1.
Ma L, Tang H, Yin Y, Yu R, Zhao J, Li Y, Mulholland MW, Zhang W., Free PMC Article | 09/3/2016 |