| Cathepsin L induces cellular senescence by upregulating CUX1 and p16[INK4a]. | Cathepsin L induces cellular senescence by upregulating CUX1 and p16(INK4a).
Wu Y, Jiang D, Liu Q, Yan S, Liu X, Wu T, Sun W, Li G., Free PMC Article | 08/30/2024 |
| Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage. | Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage.
Bestle D, Bittel L, Werner AD, Kämper L, Dolnik O, Krähling V, Steinmetzer T, Böttcher-Friebertshäuser E., Free PMC Article | 08/29/2024 |
| P300 Participates in Ionizing Radiation-Mediated Activation of Cathepsin L by Mutant p53. | P300 Participates in Ionizing Radiation-Mediated Activation of Cathepsin L by Mutant p53.
Xiong YJ, Zhu Y, Liu YL, Zhao YF, Shen X, Zuo WQ, Lin F, Liang ZQ. | 07/29/2024 |
| Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer. | Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer.
Xu J, Xu W, Choi J, Brhane Y, Christiani DC, Kothari J, McKay J, Field JK, Davies MPA, Liu G, Amos CI, Hung RJ, Briollais L., Free PMC Article | 10/2/2023 |
| Methyltransferase-like 3 promotes cervical cancer metastasis by enhancing cathepsin L mRNA stability in an N6-methyladenosine-dependent manner. | Methyltransferase-like 3 promotes cervical cancer metastasis by enhancing cathepsin L mRNA stability in an N6-methyladenosine-dependent manner.
Liu P, Ju M, Zheng X, Jiang Y, Yu X, Pan B, Luo R, Jia W, Zheng M., Free PMC Article | 03/13/2023 |
| Reduced Cathepsin L expression and secretion into the extracellular milieu contribute to lung fibrosis in systemic sclerosis. | Reduced Cathepsin L expression and secretion into the extracellular milieu contribute to lung fibrosis in systemic sclerosis.
Mouawad JE, Sharma S, Renaud L, Pilewski JM, Nadig SN, Feghali-Bostwick C., Free PMC Article | 03/8/2023 |
| A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer. | A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer.
Cui K, Yao S, Liu B, Sun S, Gong L, Li Q, Fei B, Huang Z., Free PMC Article | 10/15/2022 |
| COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2. | COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2.
Zhang L, Wei C, Li D, He J, Liu S, Deng H, Cheng J, Du J, Liu X, Chen H, Sun S, Yu H, Fu J., Free PMC Article | 04/23/2022 |
| Expressions and significances of CTSL, the target of COVID-19 on GBM. | Expressions and significances of CTSL, the target of COVID-19 on GBM.
Dong Q, Li Q, Duan L, Wang H, Yan Y, Yin H, Niu L, Zhang H, Wang B, Yuan G, Pan Y., Free PMC Article | 03/12/2022 |
| XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells. | XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells.
Khan S, Cvammen W, Anabtawi N, Choi JH, Kemp MG., Free PMC Article | 01/29/2022 |
| Mechanisms of L-Serine-Mediated Neuroprotection Include Selective Activation of Lysosomal Cathepsins B and L. | Mechanisms of L-Serine-Mediated Neuroprotection Include Selective Activation of Lysosomal Cathepsins B and L.
Dunlop RA, Carney JM. | 12/11/2021 |
| The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis. | The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis.
Wang X, Li X, Lin F, Sun H, Lin Y, Wang Z, Wang X., Free PMC Article | 11/27/2021 |
| Upregulation of cathepsin L gene under mild cold conditions in young Japanese male adults. | Upregulation of cathepsin L gene under mild cold conditions in young Japanese male adults.
Yasukochi Y, Shin S, Wakabayashi H, Maeda T., Free PMC Article | 10/30/2021 |
| Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion. | Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion.
Sankpal NV, Brown TC, Fleming TP, Herndon JM, Amaravati AA, Loynd AN, Gillanders WE., Free PMC Article | 10/23/2021 |
| The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies. | The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies.
Čaval T, Hecht ES, Tang W, Uy-Gomez M, Nichols A, Kil YJ, Sandoval W, Bern M, Heck AJR., Free PMC Article | 10/2/2021 |
| Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L. | Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L.
Prasad K, AlOmar SY, Almuqri EA, Rudayni HA, Kumar V., Free PMC Article | 08/28/2021 |
| Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy. | Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy.
Niu R, Wang J, Geng C, Li Y, Dong L, Liu L, Chang Y, Shen J, Nie Z, Zhang Y, Hu B., Free PMC Article | 05/8/2021 |
| Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. | Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development.
Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK., Free PMC Article | 04/17/2021 |
| Female reproductive tract has low concentration of SARS-CoV2 receptors. | Female reproductive tract has low concentration of SARS-CoV2 receptors.
Goad J, Rudolph J, Rajkovic A., Free PMC Article | 02/13/2021 |
| Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics. | Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics.
Gomes CP, Fernandes DE, Casimiro F, da Mata GF, Passos MT, Varela P, Mastroianni-Kirsztajn G, Pesquero JB., Free PMC Article | 01/16/2021 |
| In Silico Identification of Potential Natural Product Inhibitors of Human Proteases Key to SARS-CoV-2 Infection. | In Silico Identification of Potential Natural Product Inhibitors of Human Proteases Key to SARS-CoV-2 Infection.
Vivek-Ananth RP, Rana A, Rajan N, Biswal HS, Samal A., Free PMC Article | 09/12/2020 |
| the transcriptional induction of CatB and CatL depends on the binding of PPARgamma to PPRE sequences as a PPARgamma/Retinoid X Receptor-alpha heterodimer. | Curcumin inhibits the TGF-β1-dependent differentiation of lung fibroblasts via PPARγ-driven upregulation of cathepsins B and L.
Saidi A, Kasabova M, Vanderlynden L, Wartenberg M, Kara-Ali GH, Marc D, Lecaille F, Lalmanach G., Free PMC Article | 07/25/2020 |
| Low expression of CatL and DC-SIGN is a feature of filovirus-resistant epithelial cells. | Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L.
González-Hernández M, Müller A, Hoenen T, Hoffmann M, Pöhlmann S., Free PMC Article | 07/11/2020 |
| Human omental microvascular endothelial cells Gal1 transcription and release in response to CathL secreted from metastasising high-grade serous carcinoma acts in an autocrine manner on the local microvasculature to induce pro-angiogenic changes. | Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma.
Pranjol MZI, Zinovkin DA, Maskell ART, Stephens LJ, Achinovich SL, Los' DM, Nadyrov EA, Hannemann M, Gutowski NJ, Whatmore JL., Free PMC Article | 07/11/2020 |
| Altered expression of TMPRSS2 and cathepsin L in neoplasms may facilitate cellular entry of SARSCoV2 leading to COVID-19. | Pan‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19.
Katopodis P, Anikin V, Randeva HS, Spandidos DA, Chatha K, Kyrou I, Karteris E., Free PMC Article | 07/11/2020 |