| Cutting Edge: Redundant Roles for MHC Class II-, CD1d-, and MR1-restricted T Cells in Clearing Bartonella Infection. | Cutting Edge: Redundant Roles for MHC Class II-, CD1d-, and MR1-restricted T Cells in Clearing Bartonella Infection.
Siewert LK, Fromm K, Dehio C, Pinschewer DD., Free PMC Article | 09/30/2024 |
| MR1 deficiency enhances IL-17-mediated allergic contact dermatitis. | MR1 deficiency enhances IL-17-mediated allergic contact dermatitis.
Imahashi N, Satoh M, Clemente E, Yoshino K, Di Gioacchino M, Iwabuchi K., Free PMC Article | 07/12/2023 |
| Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis. | Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis.
Wyatt-Johnson SK, Kersey HN, Codocedo JF, Newell KL, Landreth GE, Lamb BT, Oblak AL, Brutkiewicz RR., Free PMC Article | 03/29/2023 |
| Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b. | Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.
Shibata K, Motozono C, Nagae M, Shimizu T, Ishikawa E, Motooka D, Okuzaki D, Izumi Y, Takahashi M, Fujimori N, Wing JB, Hayano T, Asai Y, Bamba T, Ogawa Y, Furutani-Seiki M, Shirai M, Yamasaki S., Free PMC Article | 11/26/2022 |
| MR1-dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis. | MR1-dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis.
Naidoo K, Woods K, Pellefigues C, Cait A, O'Sullivan D, Gell K, Marshall AJ, Anderson RJ, Li Y, Schmidt A, Prasit K, Mayer JU, Gestin A, Hermans IF, Painter G, Jacobsen EA, Gasser O. | 10/16/2021 |
| Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells. | Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells.
Priya R, Brutkiewicz RR., Free PMC Article | 12/19/2020 |
| Study of wild-type (WT) and Mr1-/- mice were treated with antibiotics and then infected with Clostridium difficile (Cd) spores. Mr1-/- mice exhibited resistance to Cd colonization. This colonization resistance was transferred from Mr1-/- to WT mice via fecal microbiota transplantation, suggesting that Mr1-dependent factors influence the microbiota, leading to Clostridium difficile infection susceptibility. | Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection.
Smith AD, Foss ED, Zhang I, Hastie JL, Giordano NP, Gasparyan L, VinhNguyen LP, Schubert AM, Prasad D, McMichael HL, Sun J, Beger RD, Simonyan V, Cowley SC, Carlson PE Jr., Free PMC Article | 04/4/2020 |
| Here the authors demonstrate that major histocompatibility complex class I deficiency results in significant dendritic atrophy along with an increase in thin dendritic spines and a reduction in stubby spines in the hippocampus of aged (12 month old) mice. | Major Histocompatibility Complex class I proteins are critical for maintaining neuronal structural complexity in the aging brain.
Lazarczyk MJ, Kemmler JE, Eyford BA, Short JA, Varghese M, Sowa A, Dickstein DR, Yuk FJ, Puri R, Biron KE, Leist M, Jefferies WA, Dickstein DL., Free PMC Article | 03/31/2018 |
| MR1 tetramers allow precise phenotypic characterization of human and mouse mucosal-associated invariant T cells. | Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells.
Reantragoon R, Corbett AJ, Sakala IG, Gherardin NA, Furness JB, Chen Z, Eckle SB, Uldrich AP, Birkinshaw RW, Patel O, Kostenko L, Meehan B, Kedzierska K, Liu L, Fairlie DP, Hansen TH, Godfrey DI, Rossjohn J, McCluskey J, Kjer-Nielsen L., Free PMC Article | 12/21/2013 |
| differential contribution of particular amino acids to the MAIT TCR-MR1 interaction based upon the presence of bacteria | MAIT cell recognition of MR1 on bacterially infected and uninfected cells.
Young MH, U'Ren L, Huang S, Mallevaey T, Scott-Browne J, Crawford F, Lantz O, Hansen TH, Kappler J, Marrack P, Gapin L., Free PMC Article | 07/6/2013 |
| The results of this study supported that MHCI appears to differentially modulate neuritogenesis and synaptogenesis. | Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.
Bilousova T, Dang H, Xu W, Gustafson S, Jin Y, Wickramasinghe L, Won T, Bobarnac G, Middleton B, Tian J, Kaufman DL., Free PMC Article | 07/14/2012 |
| Data suggest that constitutive expression of MR1 may be detrimental for maintenance of immune homeostasis in the gut and/or detection of pathogenic bacteria in mucosal tissues. | Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cells.
Chua WJ, Kim S, Myers N, Huang S, Yu L, Fremont DH, Diamond MS, Hansen TH., Free PMC Article | 08/6/2011 |
| The study demonistrated that the enhanced neuronal MHCI expression as a beneficial factor for promoting recovery of locomotor function after spinal cord injury. | Transgenic mice with enhanced neuronal major histocompatibility complex class I expression recover locomotor function better after spinal cord injury.
Joseph MS, Bilousova T, Zdunowski S, Wu ZP, Middleton B, Boudzinskaia M, Wong B, Ali N, Zhong H, Yong J, Washburn L, Escande-Beillard N, Dang H, Edgerton VR, Tillakaratne NJ, Kaufman DL., Free PMC Article | 05/7/2011 |
| fact that MR1 seems mainly intracellular might offer clues as to the process, given the precedence in other class I molecules | The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice.
Georgel P, Radosavljevic M, Macquin C, Bahram S. | 02/26/2011 |
| Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice. | Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice.
Dai W, He W, Shang G, Jiang J, Wang Y, Kong W. | 12/4/2010 |
| the presentation pathway of MR1 to MAIT cells is highly evolutionarily conserved | MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution.
Huang S, Martin E, Kim S, Yu L, Soudais C, Fremont DH, Lantz O, Hansen TH., Free PMC Article | 01/21/2010 |
| MR1 traffics through endocytic compartments, thereby allowing mucosal-associated invariant T cells to sample both endocytosed and endogenous antigens. | MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells.
Huang S, Gilfillan S, Kim S, Thompson B, Wang X, Sant AJ, Fremont DH, Lantz O, Hansen TH., Free PMC Article | 01/21/2010 |
| HA peptides are expressed by EGCs and recognized by CD8 T cells that express a T-cell receptor (TCR) specific for Kd:HA512-520 (CL4) or CD4 T cells that express a TCR specific for IEd:HA107-119 (6.5), respectively. | Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity.
Magnusson FC, Liblau RS, von Boehmer H, Pittet MJ, Lee JW, Turley SJ, Khazaie K. | 01/21/2010 |
| MR1 protein can associate with beta(2)-microglobulin | Association of MR1 protein, an MHC class I-related molecule, with beta(2)-microglobulin.
Yamaguchi H, Hashimoto K. | 01/21/2010 |
| Analysis of murine MR1 expressed in a murine cell line reveals that MR1 associates with the peptide-loading complex, indicating that MR1 uses the same cellular assembly machinery as do classical class I molecules. | Biochemical features of the MHC-related protein 1 consistent with an immunological function.
Miley MJ, Truscott SM, Yu YY, Gilfillan S, Fremont DH, Hansen TH, Lybarger L. | 01/21/2010 |
| MR1 has an antigen presentation function | Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.
Huang S, Gilfillan S, Cella M, Miley MJ, Lantz O, Lybarger L, Fremont DH, Hansen TH. | 01/21/2010 |
| Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1 | Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1.
Treiner E, Duban L, Bahram S, Radosavljevic M, Wanner V, Tilloy F, Affaticati P, Gilfillan S, Lantz O. | 01/21/2010 |