| CTPS1 inhibition suppresses proliferation and migration in colorectal cancer cells. | CTPS1 inhibition suppresses proliferation and migration in colorectal cancer cells.
Wu F, Mao Y, Ma T, Wang X, Wei H, Wang T, Wang J, Zhang Y., Free PMC Article | 12/3/2022 |
| CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1. | CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1.
Lin Y, Zhang J, Li Y, Guo W, Chen L, Chen M, Chen X, Zhang W, Jin X, Jiang M, Xiao H, Wang C, Song C, Fu F., Free PMC Article | 03/26/2022 |
| Energy deficiency caused by CTPS downregulation in decidua may contribute to pre-eclampsia by impairing decidualization. | Energy deficiency caused by CTPS downregulation in decidua may contribute to pre-eclampsia by impairing decidualization.
Ma K, Li N, Yan X, Zhu Y, Zhang C. | 11/13/2021 |
| Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation. | Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.
Martin E, Minet N, Boschat AC, Sanquer S, Sobrino S, Lenoir C, de Villartay JP, Leite-de-Moraes M, Picard C, Soudais C, Bourne T, Hambleton S, Hughes SM, Wynn RF, Briggs TA, Genomics England Research Consortium, Patel S, Lawrence MG, Fischer A, Arkwright PD, Latour S., Free PMC Article | 06/26/2021 |
| CTP synthase forms the cytoophidium in human hepatocellular carcinoma. | CTP synthase forms the cytoophidium in human hepatocellular carcinoma.
Chang CC, Jeng YM, Peng M, Keppeke GD, Sung LY, Liu JL. | 12/2/2017 |
| The filament structures elucidate allosteric mechanisms of assembly and regulation that rely on a conserved conformational equilibrium. The findings may provide a mechanism for increasing human CTP synthase activity in response to metabolic state and challenge the assumption that metabolic filaments are generally storage forms of inactive enzymes. | Human CTP synthase filament structure reveals the active enzyme conformation.
Lynch EM, Hicks DR, Shepherd M, Endrizzi JA, Maker A, Hansen JM, Barry RM, Gitai Z, Baldwin EP, Kollman JM., Free PMC Article | 07/15/2017 |
| Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings. | Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
Calise SJ, Carcamo WC, Krueger C, Yin JD, Purich DL, Chan EK., Free PMC Article | 09/6/2014 |
| results highlight a key and specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response | CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation.
Martin E, Palmic N, Sanquer S, Lenoir C, Hauck F, Mongellaz C, Fabrega S, Nitschké P, Esposti MD, Schwartzentruber J, Taylor N, Majewski J, Jabado N, Wynn RF, Picard C, Fischer A, Arkwright PD, Latour S., Free PMC Article | 07/19/2014 |
| analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser(68) is a major site of CTPS2 regulation by phosphorylation | Regulation of human cytidine triphosphate synthetase 2 by phosphorylation.
Kassel KM, Au da R, Higgins MJ, Hines M, Graves LM., Free PMC Article | 11/27/2010 |
| studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization | Human cytidine triphosphate synthetase 1 interacting proteins.
Higgins MJ, Loiselle D, Haystead TA, Graves LM. | 01/21/2010 |
| analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity | Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3.
Higgins MJ, Graves PR, Graves LM. | 01/21/2010 |
| Data indicate that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity. | Phosphorylation of human CTP synthetase 1 by protein kinase C: identification of Ser(462) and Thr(455) as major sites of phosphorylation.
Chang YF, Martin SS, Baldwin EP, Carman GM., Free PMC Article | 01/21/2010 |
| CTP synthetase is phosphorylated by protein kinase A | Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.
Han GS, Sreenivas A, Choi MG, Chang YF, Martin SS, Baldwin EP, Carman GM., Free PMC Article | 01/21/2010 |