| Severe manifestation of Rauch-Azzarello syndrome associated with biallelic deletion of CTNND2. | Severe manifestation of Rauch-Azzarello syndrome associated with biallelic deletion of CTNND2.
Pauly M, Krumbiegel M, Trumpp S, Braig S, Rupprecht T, Kraus C, Uebe S, Reis A, Vasileiou G. | 07/24/2024 |
| microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting delta-catenin, a novel catenin in asthma. | microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting δ-catenin, a novel catenin in asthma.
Liang Y, Feng Y, Wu W, Chang C, Chen D, Chen S, Zhen G. | 06/26/2021 |
| A child with autism, behavioral issues, and dysmorphic features found to have a tandem duplication within CTNND2 by mate-pair sequencing. | A child with autism, behavioral issues, and dysmorphic features found to have a tandem duplication within CTNND2 by mate-pair sequencing.
Miller DE, Squire A, Bennett JT. | 01/9/2021 |
| Intratumor delta-catenin heterogeneity driven by genomic rearrangement dictates growth factor dependent prostate cancer progression. | Intratumor δ-catenin heterogeneity driven by genomic rearrangement dictates growth factor dependent prostate cancer progression.
Li M, Nopparat J, Aguilar BJ, Chen YH, Zhang J, Du J, Ai X, Luo Y, Jiang Y, Boykin C, Lu Q., Free PMC Article | 12/5/2020 |
| EIF3J-AS1 promotes CTNND2 expression via sponging miR-122-5p. Hypoxia-induced EIF3J-AS1 facilitates hepatocellular carcinoma progression via regulating CTNND2. | Hypoxia-induced lncRNA EIF3J-AS1 accelerates hepatocellular carcinoma progression via targeting miR-122-5p/CTNND2 axis.
Yang X, Yao B, Niu Y, Chen T, Mo H, Wang L, Guo C, Yao D. | 06/20/2020 |
| The increase in invasive capacity induced by bevacizumab therapy was associated with upregulation of delta-catenin expression in invasive tumor cells. This finding suggests that delta-catenin is related to tumor invasion and migration. | δ-Catenin Promotes Bevacizumab-Induced Glioma Invasion.
Shimizu T, Ishida J, Kurozumi K, Ichikawa T, Otani Y, Oka T, Tomita Y, Hattori Y, Uneda A, Matsumoto Y, Date I. | 02/29/2020 |
| These results add further insights into the epigenetic regulation of insulin sensitivity and associated complications, pointing the CTNND2 and LPL genes as potential underlying epigenetic biomarkers for future risk of insulin-related diseases. | Insulin Sensitivity Is Associated with Lipoprotein Lipase (LPL) and Catenin Delta 2 (CTNND2) DNA Methylation in Peripheral White Blood Cells in Non-Diabetic Young Women.
Arpón A, Santos JL, Milagro FI, Cataldo LR, Bravo C, Riezu-Boj JI, Martínez JA., Free PMC Article | 12/7/2019 |
| Data provide evidence that delta-catenin may serve an important role in the malignancy of lung adenocarcinoma through activation of canonical Wnt signaling and cancer stem cell maintenance. | δ-Catenin promotes tumorigenesis and metastasis of lung adenocarcinoma.
Huang F, Chen J, Wang Z, Lan R, Fu L, Zhang L. | 08/25/2018 |
| Gene Ontology analysis revealed that neuronal differentiation-related genes were enriched among targets that were co-regulated by REST and TRIM28, while the level of CTNND2 was increased by the knockdown of REST and TRIM28. Consistently, during neuronal differentiation, the level of CTNND2 increased while those of REST and TRIM28 decreased, suggesting that CTNND2 expression may be co-regulated by both. | Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.
Lee N, Park SJ, Haddad G, Kim DK, Park SM, Park SK, Choi KY., Free PMC Article | 06/23/2018 |
| We propose CTNND2 as the causal gene infamilial cortical myoclonic tremor and epilepsy-3 | δ-Catenin (CTNND2) missense mutation in familial cortical myoclonic tremor and epilepsy.
van Rootselaar AF, Groffen AJ, de Vries B, Callenbach PMC, Santen GWE, Koelewijn S, Vijfhuizen LS, Buijink A, Tijssen MAJ, van den Maagdenberg AMJM. | 12/16/2017 |
| At the molecular level, CTNND2 is at the crossroad with interactions to such signaling pathways of Wnt and Rho family small GTPases in the Ras superfamily, which are known to drive human disease pathogenesis. | Genetic alterations of δ-catenin/NPRAP/Neurojungin (CTNND2): functional implications in complex human diseases.
Lu Q, Aguilar BJ, Li M, Jiang Y, Chen YH., Free PMC Article | 05/20/2017 |
| Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated. | Association of ZNF644, GRM6, and CTNND2 genes with high myopia in the Han Chinese population: Jiangsu Eye Study.
Wang H, Su S, Yang M, Hu N, Yao Y, Zhu R, Zhou J, Liang C, Guan H., Free PMC Article | 03/18/2017 |
| Multigenerational autosomal dominant inheritance of 5p chromosomal deletions resulting in Cri-du-Chat Syndrome with SEMA5A, CTNND2, and ICE1 deficiencies has been described. | Multigenerational autosomal dominant inheritance of 5p chromosomal deletions.
Zhang B, Willing M, Grange DK, Shinawi M, Manwaring L, Vineyard M, Kulkarni S, Cottrell CE. | 12/17/2016 |
| the effect of CTNND2 polymorphisms on normal variability and identified a polymorphism (rs2561622) with significant effect on phonological ability and white matter volume in the left frontal lobe, was investigated. | CTNND2-a candidate gene for reading problems and mild intellectual disability.
Hofmeister W, Nilsson D, Topa A, Anderlid BM, Darki F, Matsson H, Tapia Páez I, Klingberg T, Samuelsson L, Wirta V, Vezzi F, Kere J, Nordenskjöld M, Syk Lundberg E, Lindstrand A. | 02/27/2016 |
| Study describes two Ion-syndromic intellectual disability cases, positive for the presence of a small copy number variants, intragenic CTNND2 gene deletion. | CTNND2 deletion and intellectual disability.
Belcaro C, Dipresa S, Morini G, Pecile V, Skabar A, Fabretto A. | 07/4/2015 |
| Results conclude that the introduction of CTNND2 gene variation is an important milestone in prostate cancer metabolic adaptation. | δ-Catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.
Nopparat J, Zhang J, Lu JP, Chen YH, Zheng D, Neufer PD, Fan JM, Hong H, Boykin C, Lu Q., Free PMC Article | 06/20/2015 |
| co-expression of Delta-catenin and RhoA was significantly associated with histological type, differentiation, pTNM stage, lymphatic metastasis and a poor prognosis in non-small cell lung cancer | Co-expression of delta-catenin and RhoA is significantly associated with a malignant lung cancer phenotype.
Zhang D, Zhang JY, Dai SD, Liu SL, Liu Y, Tang N, Wang EH., Free PMC Article | 05/16/2015 |
| our results suggest that delta-catenin acts as an oncoprotein when overexpressed in esophageal squamous cell carcinoma | The expression of δ-catenin in esophageal squamous cell carcinoma and its correlations with prognosis of patients.
Zhang JY, Bai CY, Bai YQ, Zhang JY, Wu ZY, Wang SH, Xu XE, Wu JY, Zhu Y, Rui Y, Li EM, Xu LY. | 12/20/2014 |
| SNPs in CTNND2 showed an increased signal for schizophrenia and major depressive disorder, but not for bipolar disorder. The association between CTNND2 and anxiety was not strong enough in current generation of human genome-wide analyses. | Further confirmation of the association between anxiety and CTNND2: replication in humans.
Nivard MG, Mbarek H, Hottenga JJ, Smit JH, Jansen R, Penninx BW, Middeldorp CM, Boomsma DI. | 09/27/2014 |
| delta-catenin upregulates the activity of cdc42 and Rac1 GTPases at transcriptional level, and their coexpression predict a poor clinical outcome in nonsmall cell lung cancer patients | Overexpression of small GTPases directly correlates with expression of δ-catenin and their coexpression predicts a poor clinical outcome in nonsmall cell lung cancer.
Zhang JY, Zhang D, Wang EH. | 06/8/2013 |
| Genome-wide significant association with CTNND2 single nucleotide polymorphisms rs17183619, rs13155993 and rs13170756 for the bivariate outcome of cortical cataract and temporal horn volume, is reported. | δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.
Jun G, Moncaster JA, Koutras C, Seshadri S, Buros J, McKee AC, Levesque G, Wolf PA, St George-Hyslop P, Goldstein LE, Farrer LA., Free PMC Article | 03/16/2013 |
| Specific polymorphisms in the CTNND2 gene and 11q24.1 genomic region were found to be significantly associated with pathological myopia in this Chinese population. | Polymorphisms in the CTNND2 gene and 11q24.1 genomic region are associated with pathological myopia in a Chinese population.
Yu Z, Zhou J, Chen X, Zhou X, Sun X, Chu R. | 10/6/2012 |
| Multiple genes linked to Alzheimer's disease are regulated by NPRAP. Furthermore, NPRAP nuclear translocation is required for gene regulation. | A nuclear function for the presenilin 1 neuronal partner NPRAP/δ-catenin.
Koutras C, Lessard CB, Lévesque G. | 08/18/2012 |
| These results confirmed the strong association between CTNND2 polymorphism and myopia. | Replication study supports CTNND2 as a susceptibility gene for high myopia.
Lu B, Jiang D, Wang P, Gao Y, Sun W, Xiao X, Li S, Jia X, Guo X, Zhang Q. | 12/17/2011 |
| The studies support coordinated regulation of delta-catenin expression by both the activating transcription factor E2F1 and repressive transcription factor Hes1 in prostate cancer progression. | Human homolog of Drosophila Hairy and enhancer of split 1, Hes1, negatively regulates δ-catenin (CTNND2) expression in cooperation with E2F1 in prostate cancer.
Lu JP, Zhang J, Kim K, Case TC, Matusik RJ, Chen YH, Wolfe M, Nopparat J, Lu Q., Free PMC Article | 03/26/2011 |