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    CTLA4 cytotoxic T-lymphocyte associated protein 4 [ Homo sapiens (human) ]

    Gene ID: 1493, updated on 22-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CTLA-4 expression and polymorphisms in Schizophrenia; a systematic review of literature.

    CTLA-4 expression and polymorphisms in Schizophrenia; a systematic review of literature.
    Fayedeh F, Khorashadizadeh S, Yousefi M, Abbasifar S, Erfanian N, Rafiee M, Ghasemi F.

    04/17/2024
    TIM3 and CTLA4 immune checkpoint polymorphisms are associated with acute myeloid leukemia in Saudi Arabia.

    TIM3 and CTLA4 immune checkpoint polymorphisms are associated with acute myeloid leukemia in Saudi Arabia.
    Alqahtani M, Aljuaimlani A, Al-Tamimi J, Alomar S, Mansour L.

    03/29/2024
    Association between CTLA4 + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis.

    Association between CTLA4 + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis.
    Tan X, Liu C, Sun L.

    03/21/2024
    Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells.

    Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells.
    Ding R, Yu X, Hu Z, Dong Y, Huang H, Zhang Y, Han Q, Ni ZY, Zhao R, Ye Y, Zou Q.

    03/21/2024
    Dual silencing of tumor-intrinsic VISTA and CTLA-4 stimulates T-cell mediated immune responses and inhibits MCF7 breast cancer development.

    Dual silencing of tumor-intrinsic VISTA and CTLA-4 stimulates T-cell mediated immune responses and inhibits MCF7 breast cancer development.
    Hosseinkhani N, Hemmat N, Baghbani E, Baghbanzadeh A, Kazemi T, Mokhtarzadeh A, Jafarlou M, Amin Doustvandi M, Baradaran B.

    02/1/2024
    Detection of CTLA-4 level and humeral immune response after the second dose of COVID-19 vaccine in certain Iraqi provinces participants.

    Detection of CTLA-4 level and humeral immune response after the second dose of COVID-19 vaccine in certain Iraqi provinces participants.
    Al-Kaif LAIK, Al-Ameri H, Alfatlawi WRO, Mahdi AE, Al-Khafaji YAK, Al-Saadi MA, Al-Charrakh AH, Al-Mammori RT, Akkaif MA., Free PMC Article

    01/30/2024
    Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells.

    Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells.
    Agarwal S, Aznar MA, Rech AJ, Good CR, Kuramitsu S, Da T, Gohil M, Chen L, Hong SA, Ravikumar P, Rennels AK, Salas-Mckee J, Kong W, Ruella M, Davis MM, Plesa G, Fraietta JA, Porter DL, Young RM, June CH.,

    01/9/2024
    Targeting CTLA-4: a possible solution for microsatellite-stable colorectal cancer.

    Targeting CTLA-4: a possible solution for microsatellite-stable colorectal cancer.
    Ghiringhelli F, Thibaudin M.

    12/18/2023
    DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.

    DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.
    Turnbull C, Bones J, Stanley M, Medhavy A, Wang H, Lorenzo AMD, Cappello J, Shanmuganandam S, Pandey A, Seneviratne S, Brown GJ, Meng X, Fulcher D, Burgio G, Man SM, de Lucas Collantes C, Gasior M, López Granados E, Martin P, Jiang SH, Cook MC, Ellyard JI, Athanasopoulos V, Corry B, Canete PF, Vinuesa CG., Free PMC Article

    12/18/2023
    Computational analysis of structural and functional evaluation of the deleterious missense variants in the human CTLA4 gene.

    Computational analysis of structural and functional evaluation of the deleterious missense variants in the human CTLA4 gene.
    Bouqdayr M, Abbad A, Baba H, Saih A, Wakrim L, Kettani A.

    12/18/2023
    The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8[+] T-cell immunity.

    The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8(+) T-cell immunity.
    Yu J, Cui J, Zhang X, Xu H, Chen Z, Li Y, Niu Y, Wang S, Ran S, Zou Y, Ye W, Zhang D, Zhou C, Xia J, Wu J.,

    12/4/2023
    Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry.

    Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry.
    Rojas-Restrepo J, Sindram E, Zenke S, Haberstroh H, Mitsuiki N, Gabrysch A, Huebscher K, Posadas-Cantera S, Krausz M, Kobbe R, Rohr JC, Grimbacher B, Gámez-Díaz L., Free PMC Article

    11/27/2023
    The Expression of CTLA-4 in Breast Tumors and Tumor-Infiltrating Leukocytes Affects Patients' Systemic Inflammatory Status and Varies According to Their Molecular Subtypes.

    The Expression of CTLA-4 in Breast Tumors and Tumor-Infiltrating Leukocytes Affects Patients' Systemic Inflammatory Status and Varies According to Their Molecular Subtypes.
    Kern R, da Silva JC, Negretti F, Ferreira MO, Coletto MIO, de Oliveira ST, Alves FM, Scandolara TB, Rech D, Panis C.

    11/3/2023
    Management and outcome of COVID-19 in CTLA-4 insufficiency.

    Management and outcome of COVID-19 in CTLA-4 insufficiency.
    Ochoa S, Abers MS, Rosen LB, Rump A, Howe K, Lieberman JA, Wright BL, Suez D, Krausz M, Grimbacher B, Lionakis MS, Uzel G., Free PMC Article

    09/29/2023
    Detailed characterization of PD-1/PD-L1 and CTLA4 expression and tumor-infiltrating lymphocytes in yolk sac tumors.

    Detailed characterization of PD-1/PD-L1 and CTLA4 expression and tumor-infiltrating lymphocytes in yolk sac tumors.
    Zhang D, Xu H, Zhao C, Qin L, Wei R, Xi L, Li F.

    09/28/2023
    Germline variants of the immune checkpoint proteins PD-1, PD-l1 and CTLA-4 and immune tolerance induction outcome in patients with inherited haemophilia A.

    Germline variants of the immune checkpoint proteins PD-1, PD-l1 and CTLA-4 and immune tolerance induction outcome in patients with inherited haemophilia A.
    Zuccherato LW, Camelo RM, Chaves DG, Rezende SM.

    09/20/2023
    Correlation of CTLA-4 polymorphism and the risk of gastric cancer in a Chinese Bai population.

    Correlation of CTLA-4 polymorphism and the risk of gastric cancer in a Chinese Bai population.
    Yan P, Kong S, Zheng Y, Cheng M, Zhao W.

    09/11/2023
    Evaluation of CTLA-4 (+ 49A/G) polymorphism association with rheumatoid arthritis in Egyptian patients.

    Evaluation of CTLA-4 (+ 49A/G) polymorphism association with rheumatoid arthritis in Egyptian patients.
    Ragab D, Hammoda RM, El-Gharbawy NH, Salem R.

    08/31/2023
    CTLA-4 Pathway Is Instrumental in Giant Cell Arteritis.

    CTLA-4 Pathway Is Instrumental in Giant Cell Arteritis.
    Régnier P, Le Joncour A, Maciejewski-Duval A, Darrasse-Jèze G, Dolladille C, Meijers WC, Bastarache L, Fouret P, Bruneval P, Arbaretaz F, Sayetta C, Márquez A, Rosenzwajg M, Klatzmann D, Cacoub P, Moslehi JJ, Salem JE, Saadoun D.

    08/7/2023
    Circulating Th2-biased T follicular helper cells impede antiviral humoral responses during chronic hepatitis B infection through upregulating CTLA4.

    Circulating Th2-biased T follicular helper cells impede antiviral humoral responses during chronic hepatitis B infection through upregulating CTLA4.
    Yin S, Wang J, Chen L, Mao M, Issa R, Geng Y, Huang R, Tong X, Liu Y, Wu C, Chen Y, Li J.

    08/4/2023
    Current understanding of CTLA-4: from mechanism to autoimmune diseases.

    Current understanding of CTLA-4: from mechanism to autoimmune diseases.
    Hossen MM, Ma Y, Yin Z, Xia Y, Du J, Huang JY, Huang JJ, Zou L, Ye Z, Huang Z., Free PMC Article

    08/3/2023
    Expression of cytotoxic T lymphocyte-associated antigen 4, CD44, and E-cadherin in the microenvironment of breast carcinomas.

    Expression of cytotoxic T lymphocyte-associated antigen 4, CD44, and E-cadherin in the microenvironment of breast carcinomas.
    Savli TB, Pasaoglu HE, Savli TC, Muhammedoglu A, Tokocin M, Öztürk Ç., Free PMC Article

    07/24/2023
    Cytotoxic T-lymphocyte-associated protein 4 +49A/G polymorphism in Down syndrome children with Hashimoto's thyroiditis.

    Cytotoxic T-lymphocyte-associated protein 4 +49A/G polymorphism in Down syndrome children with Hashimoto's thyroiditis.
    Faizi M, Rochmah N, Hisbiyah Y, Perwitasari RK, Putri QAN, Basuki S, Endaryanto A, Soetjipto S., Free PMC Article

    07/7/2023
    CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4[+] T cells.

    CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4(+) T cells.
    Hao Y, Miraghazadeh B, Chand R, Davies AR, Cardinez C, Kwong K, Downes MB, Sweet RA, Cañete PF, D'Orsogna LJ, Fulcher DA, Choo S, Yip D, Peters G, Yip S, Witney MJ, Nekrasov M, Feng ZP, Tscharke DC, Vinuesa CG, Cook MC., Free PMC Article

    07/4/2023
    NBEAL2 deficiency in humans leads to low CTLA-4 expression in activated conventional T cells.

    NBEAL2 deficiency in humans leads to low CTLA-4 expression in activated conventional T cells.
    Delage L, Carbone F, Riller Q, Zachayus JL, Kerbellec E, Buzy A, Stolzenberg MC, Luka M, de Cevins C, Kalouche G, Favier R, Michel A, Meynier S, Corneau A, Evrard C, Neveux N, Roudières S, Pérot BP, Fusaro M, Lenoir C, Pellé O, Parisot M, Bras M, Héritier S, Leverger G, Korganow AS, Picard C, Latour S, Collet B, Fischer A, Neven B, Magérus A, Ménager M, Pasquier B, Rieux-Laucat F., Free PMC Article

    06/28/2023
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