| Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells. | Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells.
Mai D, Johnson O, Reff J, Fan TJ, Scholler J, Sheppard NC, June CH., Free PMC Article | 03/27/2023 |
| miR-150 promotes progressive T cell differentiation via inhibiting FOXP1 and RC3H1. | miR-150 promotes progressive T cell differentiation via inhibiting FOXP1 and RC3H1.
Xia S, Huang J, Yan L, Han J, Zhang W, Shao H, Shen H, Wang J, Wang J, Tao C, Wang D, Wu F. | 10/22/2022 |
| Dynamic Regulation of the Nexus Between Stress Granules, Roquin, and Regnase-1 Underlies the Molecular Pathogenesis of Warfare Vesicants. | Dynamic Regulation of the Nexus Between Stress Granules, Roquin, and Regnase-1 Underlies the Molecular Pathogenesis of Warfare Vesicants.
Srivastava RK, Mishra B, Muzaffar S, Gorbatyuk MS, Agarwal A, Mukhtar MS, Athar M., Free PMC Article | 03/5/2022 |
| Roquin1 inhibits the proliferation of breast cancer cells by inducing G1/S cell cycle arrest via selectively destabilizing the mRNAs of cell cycle-promoting genes. | Roquin1 inhibits the proliferation of breast cancer cells by inducing G1/S cell cycle arrest via selectively destabilizing the mRNAs of cell cycle-promoting genes.
Lu W, Zhou M, Wang B, Liu X, Li B., Free PMC Article | 08/7/2021 |
| MAP7 interacts with RC3H1 and cooperatively regulate cell-cycle progression of cervical cancer cells via activating the NF-kappaB signaling. | MAP7 interacts with RC3H1 and cooperatively regulate cell-cycle progression of cervical cancer cells via activating the NF-κB signaling.
Zhang R, Li L, Chen L, Suo Y, Fan J, Zhang S, Wang Y, Gao S, Wang Y. | 01/9/2021 |
| Structural basis for the recognition of transiently structured AU-rich elements by Roquin. | Structural basis for the recognition of transiently structured AU-rich elements by Roquin.
Binas O, Tants JN, Peter SA, Janowski R, Davydova E, Braun J, Niessing D, Schwalbe H, Weigand JE, Schlundt A., Free PMC Article | 09/19/2020 |
| Transcriptome profiling revealed Roquin-dependent global downregulation of proinflammatory cytokines and antiviral genes in by human cytomegalovirus infected cells. IFN regulatory factor 1 (IRF1), a master transcriptional activator of immune responses, identified as a Roquin target gene. Roquin reduces IRF1 expression by directly binding to its mRNA, thereby enabling suppression of a variety of antiviral genes. | Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state.
Song J, Lee S, Cho DY, Lee S, Kim H, Yu N, Lee S, Ahn K., Free PMC Article | 04/11/2020 |
| analysis of previously unknown cis-regulatory elements in Roquin protein | Identification of new high affinity targets for Roquin based on structural conservation.
Braun J, Fischer S, Xu ZZ, Sun H, Ghoneim DH, Gimbel AT, Plessmann U, Urlaub H, Mathews DH, Weigand JE., Free PMC Article | 07/20/2019 |
| Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. | Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V., Free PMC Article | 02/24/2018 |
| RC3H1 is a multifunctional regulator of immune homeostasis. (Review) | Roquin--a multifunctional regulator of immune homeostasis.
Schaefer JS, Klein JR., Free PMC Article | 12/17/2016 |
| Crystal structures, small-angle X-ray scattering, and E2 profiling revealed that while the two paralogs are highly homologous, RC3H2 and RC3H1 are different in their structures and functions. | New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Zhang Q, Fan L, Hou F, Dong A, Wang YX, Tong Y., Free PMC Article | 09/10/2016 |
| A distinct, sequence-induced conformation is required for recognition of the constitutive decay element RNA by Roquin. | A Distinct, Sequence-Induced Conformation Is Required for Recognition of the Constitutive Decay Element RNA by Roquin.
Codutti L, Leppek K, Zálešák J, Windeisen V, Masiewicz P, Stoecklin G, Carlomagno T. | 05/21/2016 |
| Roquin-1 and roquin-2 proteins function redundantly in mRNA degradation. | Structure of human Roquin-2 and its complex with constitutive-decay element RNA.
Sakurai S, Ohto U, Shimizu T., Free PMC Article | 05/14/2016 |
| RC3H1 binds preferentially short-lived and DNA damage-induced mRNAs. Knockdown of RC3H1 resulted in increased A20 protein expression, thereby interfering with IkappaB kinase and NF-kappaB activities. | RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa Y, Hinz M, Mothes J, Schuetz A, Uhl M, Wyler E, Yasuda T, Mastrobuoni G, Friedel CC, Dölken L, Kempa S, Schmidt-Supprian M, Blüthgen N, Backofen R, Heinemann U, Wolf J, Scheidereit C, Landthaler M., Free PMC Article | 04/23/2016 |
| In this review we summarize current progress regarding the specific characteristics of sequences and structures in the 3' untranslated regions of mRNAs that are recognized by tristetraproline, Roquins, and Regnase-1. | Emerging Roles of CCCH-Type Zinc Finger Proteins in Destabilizing mRNA Encoding Inflammatory Factors and Regulating Immune Responses.
Yang C, Huang S, Wang X, Gu Y. | 02/6/2016 |
| decreased expression in colon biopsies of Crohn's disease patients but not in ulcerative colitis patients | MicroRNA signatures differentiate Crohn's disease from ulcerative colitis.
Schaefer JS, Attumi T, Opekun AR, Abraham B, Hou J, Shelby H, Graham DY, Streckfus C, Klein JR., Free PMC Article | 01/16/2016 |
| Roquin binding to target mRNAs involves a winged helix-turn-helix motif. | Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz A, Murakawa Y, Rosenbaum E, Landthaler M, Heinemann U. | 11/7/2015 |
| Findings reveal that differential regulation of mRNAs by Regnase-1 and Roquin depends on their translation status and enables elaborate control of inflammation. | Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.
Mino T, Murakawa Y, Fukao A, Vandenbon A, Wessels HH, Ori D, Uehata T, Tartey S, Akira S, Suzuki Y, Vinuesa CG, Ohler U, Standley DM, Landthaler M, Fujiwara T, Takeuchi O. | 08/1/2015 |
| Roquin-mediated degradation of HMGXB3 and IL6 mRNAs in human cells, demonstrates the importance of both binding sites for mRNA decay. | The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.
Tan D, Zhou M, Kiledjian M, Tong L., Free PMC Article | 10/11/2014 |
| Excessive interferon (IFN)-gamma signaling promotes accumulation of Roquin-mutated, short-lived effector-like CD8+ T cells in autoimmune-prone transgenic mice. | Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells.
Chang PP, Lee SK, Hu X, Davey G, Duan G, Cho JH, Karupiah G, Sprent J, Heath WR, Bertram EM, Vinuesa CG. | 09/22/2012 |