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    CCN2 cellular communication network factor 2 [ Homo sapiens (human) ]

    Gene ID: 1490, updated on 13-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction.

    Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction.
    Sun C, Fan W, Basha S, Tian T, Jin-Smith B, Barkin J, Xie H, Zhou J, Yin XM, Ling C, Sun B, Petersen B, Pi L., Free PMC Article

    11/13/2024
    A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass.

    A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass.
    Li S, Shao R, Li S, Zhao J, Deng Q, Li P, Wei Z, Xu S, Chen L, Li B, Zou W, Zhang Z., Free PMC Article

    10/25/2024
    The protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis.

    The protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis.
    Zhou H, Zheng D, Wang H, Wu Y, Peng X, Li Q, Li T, Liu L., Free PMC Article

    08/27/2024
    CCN2/CTGF expression does not correlate with fibrosis in myeloproliferative neoplasms, consistent with noncanonical TGF-beta signaling driving myelofibrosis.

    CCN2/CTGF expression does not correlate with fibrosis in myeloproliferative neoplasms, consistent with noncanonical TGF-β signaling driving myelofibrosis.
    Leguit RJ, Broekhuizen R, de Witte M, Raymakers RAP, Goldschmeding R., Free PMC Article

    05/28/2024
    Characterization of gastric cancer-stimulated signaling pathways and function of CTGF in cancer-associated fibroblasts.

    Characterization of gastric cancer-stimulated signaling pathways and function of CTGF in cancer-associated fibroblasts.
    Choi KM, Kim B, Lee SM, Han J, Bae HS, Han SB, Lee D, Ham IH, Hur H, Kim E, Kim JY., Free PMC Article

    01/17/2024
    CTGF regulates mineralization in human mature chondrocyte by controlling Pit-1 and modulating ANK via the BMP/Smad signalling.

    CTGF regulates mineralization in human mature chondrocyte by controlling Pit-1 and modulating ANK via the BMP/Smad signalling.
    Xiao P, Zhu Y, Xu H, Li J, Tao A, Wang H, Cheng D, Dou X, Guo L.

    01/5/2024
    CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s.

    CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s.
    Sun J, Zhang H, Liu D, Liu W, Du J, Wen D, Li L, Zhang A, Jiang J, Zeng L., Free PMC Article

    10/2/2023
    Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity.

    Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity.
    Romeo SG, Secco I, Schneider E, Reumiller CM, Santos CXC, Zoccarato A, Musale V, Pooni A, Yin X, Theofilatos K, Trevelin SC, Zeng L, Mann GE, Pathak V, Harkin K, Stitt AW, Medina RJ, Margariti A, Mayr M, Shah AM, Giacca M, Zampetaki A., Free PMC Article

    09/13/2023
    SPARC accelerates biliary tract cancer progression through CTGF-mediated tumor-stroma interactions: SPARC as a prognostic marker of survival after neoadjuvant therapy.

    SPARC accelerates biliary tract cancer progression through CTGF-mediated tumor-stroma interactions: SPARC as a prognostic marker of survival after neoadjuvant therapy.
    Takayama H, Kobayashi S, Gotoh K, Sasaki K, Iwagami Y, Yamada D, Tomimaru Y, Akita H, Asaoka T, Noda T, Wada H, Takahashi H, Tanemura M, Doki Y, Eguchi H.

    08/19/2023
    Hsa-miR-379 down-regulates Rac1/MLK3/JNK/AP-1/Collagen I cascade reaction by targeting connective tissue growth factor in human alveolar basal epithelial A549 cells.

    Hsa-miR-379 down-regulates Rac1/MLK3/JNK/AP-1/Collagen I cascade reaction by targeting connective tissue growth factor in human alveolar basal epithelial A549 cells.
    Shan J, Wu MY, Zhang YC, Lin YJ, Cheng B, Gao YR, Liu ZH, Xu HM.

    05/12/2023
    The role of YAP1 target gene CTGF in the anoikis resistance of rheumatoid arthritis synovial fibroblasts.

    The role of YAP1 target gene CTGF in the anoikis resistance of rheumatoid arthritis synovial fibroblasts.
    Janczi T, Fehrl Y, Kinne RW, Böhm B, Burkhardt H.

    02/11/2023
    The Role of CTGF in Liver Fibrosis Induced in 3D Human Liver Spheroids.

    The Role of CTGF in Liver Fibrosis Induced in 3D Human Liver Spheroids.
    Trampuž SR, van Riet S, Nordling Å, Ingelman-Sundberg M., Free PMC Article

    02/11/2023
    The carboxyl-terminal TSP1-homology domain is the biologically active effector peptide of matricellular protein CCN5 that counteracts profibrotic CCN2.

    The carboxyl-terminal TSP1-homology domain is the biologically active effector peptide of matricellular protein CCN5 that counteracts profibrotic CCN2.
    Zolfaghari S, Kaasbøll OJ, Monsen VT, Sredic B, Hagelin EMV, Attramadal H., Free PMC Article

    02/4/2023
    [Serum levels of endothelin-1 and connective tissue growth factor are elevated in patients with atrial fibrillation and correlated with relapse following radiofrequency ablation].

    [Serum levels of endothelin-1 and connective tissue growth factor are elevated in patients with atrial fibrillation and correlated with relapse following radiofrequency ablation].
    Gao Q, Geng J, Ding Y, Yao Z, Meng J, Wang C, Zhang H, Kang P, Tang B., Free PMC Article

    01/11/2023
    STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression.

    STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression.
    Makino Y, Hikita H, Kato S, Sugiyama M, Shigekawa M, Sakamoto T, Sasaki Y, Murai K, Sakane S, Kodama T, Sakamori R, Kobayashi S, Eguchi H, Takemura N, Kokudo N, Yokoi H, Mukoyama M, Tatsumi T, Takehara T., Free PMC Article

    12/31/2022
    Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury.

    Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury.
    Valentijn FA, Knoppert SN, Marquez-Exposito L, Rodrigues-Diez RR, Pissas G, Tang J, Tejedor-Santamaria L, Broekhuizen R, Samarakoon R, Eleftheriadis T, Goldschmeding R, Nguyen TQ, Ruiz-Ortega M, Falke LL.

    11/26/2022
    Comparative proteomics reveals elevated CCN2 in NGLY1-deficient cells.

    Comparative proteomics reveals elevated CCN2 in NGLY1-deficient cells.
    Hetz R, Magaway C, Everett J, Li L, Willard BB, Freeze HH, He P., Free PMC Article

    11/5/2022
    CCN2 Facilitates IL-17 Production and Osteoclastogenesis in Human Osteoarthritis Synovial Fibroblasts by Inhibiting miR-655 Expression.

    CCN2 Facilitates IL-17 Production and Osteoclastogenesis in Human Osteoarthritis Synovial Fibroblasts by Inhibiting miR-655 Expression.
    Liu SC, Hsieh HL, Tsai CH, Fong YC, Ko CY, Wu HC, Chang SL, Hsu CJ, Tang CH.

    10/29/2022
    CTGF Promotes the Osteoblast Differentiation of Human Periodontal Ligament Stem Cells by Positively Regulating BMP2/Smad Signal Transduction.

    CTGF Promotes the Osteoblast Differentiation of Human Periodontal Ligament Stem Cells by Positively Regulating BMP2/Smad Signal Transduction.
    Yan S, Zhang M, Yang G, Sun Y, Ai D., Free PMC Article

    10/8/2022
    Connective tissue growth factor promotes cementogenesis and cementum repair via Cx43/beta-catenin axis.

    Connective tissue growth factor promotes cementogenesis and cementum repair via Cx43/β-catenin axis.
    Wu Z, He Y, Chen S, Zhu L, Wang J, Zhang D, Xie J, Zou S, Zhou C., Free PMC Article

    09/17/2022
    Extracellular ATP promotes angiogenesis and adhesion of TNBC cells to endothelial cells via upregulation of CTGF.

    Extracellular ATP promotes angiogenesis and adhesion of TNBC cells to endothelial cells via upregulation of CTGF.
    Zhou YT, Yu YQ, Yang H, Yang H, Huo YF, Huang Y, Tian XX, Fang WG., Free PMC Article

    07/16/2022
    Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells.

    Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells.
    Chang HM, Bai L, Zhu YM, Leung PCK., Free PMC Article

    04/23/2022
    Connective tissue growth factor expression hints at aggressive nature of colorectal cancer.

    Connective tissue growth factor expression hints at aggressive nature of colorectal cancer.
    Bhat IP, Rather TB, Maqbool I, Rashid G, Akhtar K, Bhat GA, Parray FQ, Syed B, Khan IY, Kazi M, Hussain MD, Syed M., Free PMC Article

    04/2/2022
    Serum and glucocorticoid-regulated kinase 1 regulates transforming growth factor beta1-connective tissue growth factor pathway in chronic rhinosinusitis.

    Serum and glucocorticoid-regulated kinase 1 regulates transforming growth factor β1-connective tissue growth factor pathway in chronic rhinosinusitis.
    Lai Y, Zhang P, Wang H, Hu L, Song X, Zhang J, Jiang W, Han M, Liu Q, Hu G, Sun X, Li H, Wang D.

    02/26/2022
    Connective Tissue Growth Factor Single Nucleotide Polymorphisms in (Familial) Pulmonary Fibrosis and Connective Tissue Disease Associated Interstitial Lung Disease.

    Connective Tissue Growth Factor Single Nucleotide Polymorphisms in (Familial) Pulmonary Fibrosis and Connective Tissue Disease Associated Interstitial Lung Disease.
    Klay D, van der Vis JJ, Roothaan SM, Nguyen TQ, Grutters JC, Goldschmeding R, van Moorsel CHM.

    01/29/2022
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