| HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14. | HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.
Blakely WJ, Hatterschide J, White EA., Free PMC Article | 10/29/2024 |
| DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation. | DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.
Lou M, Huang D, Zhou Z, Shi X, Wu M, Rui Y, Su J, Zheng W, Yu XF., Free PMC Article | 01/14/2023 |
| Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18. | Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18.
Díaz-Tejeda Y, Guido-Jiménez MC, López-Carbajal H, Amador-Molina A, Méndez-Martínez R, Gariglio-Vidal P, Lizano M, García-Carrancá A., Free PMC Article | 02/12/2022 |
| CDH1 and SNAI1 are regulated by E7 from human papillomavirus types 16 and 18. | CDH1 and SNAI1 are regulated by E7 from human papillomavirus types 16 and 18.
Rosendo-Chalma P, Antonio-Vejar V, Bigoni-Ordóñez GD, Patiño-Morales CC, Cano-García A, García-Carrancá A. | 03/13/2021 |
| HPV E6 and E7 oncoproteins cooperatively alter the expression of Disc Large 1 polarity protein in epithelial cells. | HPV E6 and E7 oncoproteins cooperatively alter the expression of Disc Large 1 polarity protein in epithelial cells.
Dizanzo MP, Marziali F, Brunet Avalos C, Bugnon Valdano M, Leiva S, Cavatorta AL, Gardiol D., Free PMC Article | 01/2/2021 |
| Alternative splicing of E6E7 transcripts showed E6*I as the most frequent isoform for both viral types, followed by E6*II and E6/E7 (unspliced) transcripts in HPV16+, and by E6/E7 in HPV18+ tumors. | Characterization of HPV integration, viral gene expression and E6E7 alternative transcripts by RNA-Seq: A descriptive study in invasive cervical cancer.
Brant AC, Menezes AN, Felix SP, de Almeida LM, Sammeth M, Moreira MAM. | 04/25/2020 |
| Results indicate the significance and therapeutic potential of the intermolecular interaction between HPV18 E7 and host protein tyrosine phosphatase non-receptor type 14 (PTPN14) in HPV-mediated cell transformation and tumorigenesis. | Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus.
Yun HY, Kim MW, Lee HS, Kim W, Shin JH, Kim H, Shin HC, Park H, Oh BH, Kim WK, Bae KH, Lee SC, Lee EW, Ku B, Kim SJ., Free PMC Article | 01/25/2020 |
| These data suggest that HPV18 modulates its production ratio of E6 and E7 proteins by alternative selection of the two mapped branch sites for the E6*I splicing, which could be beneficial in its productive or oncogenic infection according to the host cell environment. | HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein.
Brant AC, Majerciak V, Moreira MAM, Zheng ZM., Free PMC Article | 06/29/2019 |
| Findings indicate O-linked N-acetylglucosamine transferase (OGT) as a cellular factor involved in human papillomaviruses type 16/18 E6 and E7 expressions and cervical cancer tumorigenesis, suggesting that targeting OGT in cervical cancer may have potential therapeutic benefit. | O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes.
Kim M, Kim YS, Kim H, Kang MY, Park J, Lee DH, Roh GS, Kim HJ, Kang SS, Cho GJ, Park JK, Cho JW, Shin JK, Choi WS., Free PMC Article | 01/13/2018 |
| HPV18 E7 inhibited the binding of CENP-C to alpha-satellite DNAs. | The human papillomavirus18 E7 protein inhibits CENP-C binding to α-satellite DNA.
Yaginuma Y, Yoshimoto M, Eguchi A, Tokuda A, Takahashi S. | 03/12/2016 |
| HPV18 E7 mRNA expression levels were not significantly altered by 10 microg/ml bee-venom-treatment in HeLa cells. | Honeybee venom possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer cell line.
Kim YW, Chaturvedi PK, Chun SN, Lee YG, Ahn WS. | 01/30/2016 |
| HPV E6/E7 RNA is differentially expressed based on lesion grade in cervical intraepithelial neoplasia | HPV E6/E7 RNA in situ hybridization signal patterns as biomarkers of three-tier cervical intraepithelial neoplasia grade.
Evans MF, Peng Z, Clark KM, Adamson CS, Ma XJ, Wu X, Wang H, Luo Y, Cooper K., Free PMC Article | 01/30/2016 |
| HPV18-E6E7 mutant (HPV18 ofmE6E7) constructed in this work not only lost the transformation capability for NIH 3T3 cells and tumorigenicity in BALB/c nude mice, but also maintained very good stability and antigenicity. | A novel mutant of human papillomavirus type 18 E6E7 fusion gene and its transforming activity.
Zhou ZX, Zhao C, Li QQ, Zeng Y. | 06/6/2015 |
| HPV16 E7 oncoprotein increases production of the IL18BP in keratinocytes. | Human papillomavirus E7 oncoprotein increases production of the anti-inflammatory interleukin-18 binding protein in keratinocytes.
Richards KH, Doble R, Wasson CW, Haider M, Blair GE, Wittmann M, Macdonald A., Free PMC Article | 06/28/2014 |
| Matrix metalloproteinases (MMP)--MMP-1,-2,-9 and its endogenous activity regulators in transformed by E7 oncogene HPV16 and HPV18 cervical carcinoma cell lines | [Matrix metalloproteinases (MMP)--MMP-1,-2,-9 and its endogenous activity regulators in transformed by E7 oncogene HPV16 and HPV18 cervical carcinoma cell lines].
Ryzhakova OS, Solov'eva NI. | 02/22/2014 |
| RNA interference effectively suppressed the expression of HPV18 E6 and E7 and VEGF in human cervical cancer cells. | Down-regulation of HPV18 E6, E7, or VEGF expression attenuates malignant biological behavior of human cervical cancer cells.
Chen L, Wu YY, Liu P, Wang J, Wang G, Qin J, Zhou J, Zhu J. | 08/25/2012 |
| study determined whether ongoing expression of HPV16 or HPV18 oncogenes is required for the proliferation of primary human cervical carcinoma cells; data suggest that E6 and E7 dependence is an inherent property of human cervical cancer cells | Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation.
Magaldi TG, Almstead LL, Bellone S, Prevatt EG, Santin AD, DiMaio D., Free PMC Article | 01/21/2012 |
| Interaction of MLL5beta with the AP-1-binding site at the distal region of the HPV18 long control region led to activation of E7 transcription. Conversely, RNA interference-mediated knockdown of MLL5beta downregulated E7 expression. | A novel MLL5 isoform that is essential to activate E6 and E7 transcription in HPV16/18-associated cervical cancers.
Yew CW, Lee P, Chan WK, Lim VK, Tay SK, Tan TM, Deng LW. | 01/14/2012 |
| These results suggest that activated expression of the E6 and E7 genes of integrated HPV is dependent on BAF53-dependent higher-order chromatin structure or nuclear motor activity. | Suppression of HPV E6 and E7 expression by BAF53 depletion in cervical cancer cells.
Lee K, Lee AY, Kwon YK, Kwon H. | 10/22/2011 |
| mechanisms by which E7 induces prolonged G(2) phase in the differentiated cells following S phase induction. | Human papillomavirus (HPV) E7 induces prolonged G2 following S phase reentry in differentiated human keratinocytes.
Banerjee NS, Wang HK, Broker TR, Chow LT., Free PMC Article | 07/16/2011 |
| Simultaneously decreasing HPV-18 E6 and E7 gene expression in HeLa cells by RNAi could significantly inhibit tumor growth under in vitro conditions and in nude mice. | Effect of simultaneous silencing of HPV-18 E6 and E7 on inducing apoptosis in HeLa cells.
Qi Z, Xu X, Zhang B, Li Y, Liu J, Chen S, Chen G, Huo X. | 01/1/2011 |
| structural basis of E7 function | A C-terminal hydrophobic, solvent-protected core and a flexible N-terminus are potentially required for human papillomavirus 18 E7 protein functionality.
Liu S, Tian Y, Greenaway FT, Sun MZ. | 09/27/2010 |
| E2F5 is an activator of E6/E7 transcription and of S-phase entry in HPV18 infected cells. | The E2F5 repressor is an activator of E6/E7 transcription and of the S-phase entry in HPV18-associated cells.
Teissier S, Pang CL, Thierry F. | 09/20/2010 |
| Dendritic cells transfected with HPV18E7-DNA were able to stimulate T-cell proliferation and HPV18E7- specific cytotoxic T-cell responses against esophageal carcinoma cells in vitro. | In vitro antigen-specific cytotoxic T cell response against esophageal carcinoma cells induced by HPV18E7-transfected dendritic cells.
Wu L, Yang W, Chen LX, Chen SR, Zhang JK. | 03/8/2010 |
| IRF-1-E7 was shown to be responsible for the positive regulation of many interleukins and to be involved in the differentiation of T-helper cells in cervical cancer | Interaction between interferon regulatory factor-1 and human papillomavirus E7 oncogene in cervical cancer: an ontology study.
Wiwanitkit V. | 01/21/2010 |