| GluR2 can Drive Neuroinflammation and Cognitive Impairments Following Peripherally Repeated Lipopolysaccharide Exposures. | GluR2 can Drive Neuroinflammation and Cognitive Impairments Following Peripherally Repeated Lipopolysaccharide Exposures.
He X, Hu XY, Yin XY, Wu XM, Liu QR, Shen JC. | 09/17/2024 |
| The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2[R/R] mice; a comparison with C57BL/6J and Adar2[-/-] mice strains. | The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2(R/R) mice; a comparison with C57BL/6J and Adar2(-/-) mice strains.
Lebedeva M, Kubištová A, Spišská V, Filipovská E, Pačesová D, Svobodová I, Kuchtiak V, Balík A, Bendová Z. | 02/20/2024 |
| The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease. | The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease.
Wright AL, Konen LM, Mockett BG, Morris GP, Singh A, Burbano LE, Milham L, Hoang M, Zinn R, Chesworth R, Tan RP, Royle GA, Clark I, Petrou S, Abraham WC, Vissel B., Free PMC Article | 09/29/2023 |
| Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke. | Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke.
Lu H, Chen S, Nie Q, Xue Q, Fan H, Wang Y, Fan S, Zhu J, Shen H, Li H, Fang Q, Ni J, Chen G. | 04/4/2023 |
| The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1. | The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1.
Zhu Z, Wang W, Gu C, Wang M, Yan Y. | 01/14/2023 |
| The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice. | The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice.
Kambe Y, Thi TN, Hashiguchi K, Sameshima Y, Yamashita A, Kurihara T, Miyata A. | 02/12/2022 |
| A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2. | A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2.
Li X, Chen W, Yu Q, Zhang Q, Zhang T, Huang X, Li H, He A, Yu H, Jing W, Du H, Ke X, Zhang B, Tian Q, Liu R, Lu Y. | 02/5/2022 |
| Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition. | Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Yu J, Rao P, Clark S, Mitra J, Ha T, Gouaux E., Free PMC Article | 01/15/2022 |
| Gating and modulation of a hetero-octameric AMPA glutamate receptor. | Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH., Free PMC Article | 01/8/2022 |
| Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates DeltaFosB and GluR2 expression. | Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression.
Nguyen ATM, Quach TVB, Kotha P, Chien SY, MacDonald IJ, Lane HY, Tu CH, Lin JG, Chen YH., Free PMC Article | 11/6/2021 |
| AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP gamma8 interactions. | AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions.
Watson JF, Pinggera A, Ho H, Greger IH., Free PMC Article | 09/4/2021 |
| AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF. | AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF.
Umanah GKE, Ghasemi M, Yin X, Chang M, Kim JW, Zhang J, Ma E, Scarffe LA, Lee YI, Chen R, Tangella K, McNamara A, Abalde-Atristain L, Dar MA, Bennett S, Cortes M, Andrabi SA, Doulias PT, Ischiropoulos H, Dawson TM, Dawson VL., Free PMC Article | 05/8/2021 |
| A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability. | A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability.
Konen LM, Wright AL, Royle GA, Morris GP, Lau BK, Seow PW, Zinn R, Milham LT, Vaughan CW, Vissel B., Free PMC Article | 02/6/2021 |
| GRIP1 regulates synaptic plasticity and learning and memory. | GRIP1 regulates synaptic plasticity and learning and memory.
Tan HL, Chiu SL, Zhu Q, Huganir RL., Free PMC Article | 11/28/2020 |
| Phosphorylation at GluA2 Y876 increases GluA2 binding to GRIP1. These results demonstrate that AMPAR trafficking during homeostatic upscaling can be gated by a single phosphorylation site on the GluA2 subunit. | Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity.
Yong AJH, Tan HL, Zhu Q, Bygrave AM, Johnson RC, Huganir RL., Free PMC Article | 07/4/2020 |
| GluA2-containing Ca(2+)-impermeable AMPA receptors contribute to signal transmission from photosensitive retinal cells to dopaminergic amacrine cells. | Expression of GluA2-containing calcium-impermeable AMPA receptors on dopaminergic amacrine cells in the mouse retina.
Liu LL, Alessio EJ, Spix NJ, Zhang DQ., Free PMC Article | 06/20/2020 |
| Nanoscale mobility of resting AMPA receptors predetermines responsiveness to neurotransmitter, allosteric anions and TARP auxiliary subunits. Mobility at rest is regulated by alternative splicing of the flip/flop cassette of the ligand-binding domain, which controls motions in the distant AMPA receptor N-terminal domain (NTD). | Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.
Dawe GB, Kadir MF, Venskutonytė R, Perozzo AM, Yan Y, Alexander RPD, Navarrete C, Santander EA, Arsenault M, Fuentes C, Aurousseau MRP, Frydenvang K, Barrera NP, Kastrup JS, Edwardson JM, Bowie D. | 03/28/2020 |
| miR-218 targets the mRNA encoding the GluA2 subunit of AMPA receptors and modulates its expression. | Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength.
Rocchi A, Moretti D, Lignani G, Colombo E, Scholz-Starke J, Baldelli P, Tkatch T, Benfenati F. | 12/21/2019 |
| Expression of the unedited (Ca(2+) permeable) or the pore-dead GluA2 subunit of AMPARs triggered proliferation of Oligodendrocyte Precursor Cell. | In Vivo Regulation of Oligodendrocyte Precursor Cell Proliferation and Differentiation by the AMPA-Receptor Subunit GluA2.
Chen TJ, Kula B, Nagy B, Barzan R, Gall A, Ehrlich I, Kukley M. | 11/16/2019 |
| Frrsl1 deletion results in an increased proportion of immature AMPA receptors, indicated by incomplete glycosylation of GLUA2 (also known as GRIA2) and GLUA4 (also known as GRIA4) AMPA receptor proteins. | Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.
Stewart M, Lau P, Banks G, Bains RS, Castroflorio E, Oliver PL, Dixon CL, Kruer MC, Kullmann DM, Acevedo-Arozena A, Wells SE, Corrochano S, Nolan PM., Free PMC Article | 08/17/2019 |
| This study reveals that the C-terminal domains of GluA1 and GluA2, the key subunits of AMPARs, are necessary and sufficient to drive NMDA receptor-dependent LTP and LTD, respectively. | The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning.
Zhou Z, Liu A, Xia S, Leung C, Qi J, Meng Y, Xie W, Park P, Collingridge GL, Jia Z. | 05/11/2019 |
| Reduced expression of Gria2 increased Ca(2+) influx through Ca(2+)-permeable AMPA receptors which increased the vulnerability and affected the differentiation and migration of distinct cell populations and interfered with normal circuit formation in fragile X syndrome. | Functional changes of AMPA responses in human induced pluripotent stem cell-derived neural progenitors in fragile X syndrome.
Achuta VS, Möykkynen T, Peteri UK, Turconi G, Rivera C, Keinänen K, Castrén ML. | 03/23/2019 |
| D2R GluA2 knockout (KO) mice showed hypoactivity, while GluA2 KO in D1R neurons had no effect on locomotor activity. D1R GluA2 KO mice showed delayed learning in the accelerating rotarod test compared with control animals, whereas D2R GluA2 KO animals exhibited complete loss of motor learning. GluA2-lacking AMPAR expression in D1R neurons induced hypersociability; D2R GluA2 KO mice elicited loss of sociability. | Distinct Roles of GluA2-lacking AMPA Receptor Expression in Dopamine D1 or D2 Receptor Neurons in Animal Behavior.
Shou J, Tran A, Snyder N, Bleem E, Kim S. | 03/23/2019 |
| defects in the brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signaling pathway contribute to the deregulated AMPAR trafficking. | Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models.
Zhang H, Zhang C, Vincent J, Zala D, Benstaali C, Sainlos M, Grillo-Bosch D, Daburon S, Coussen F, Cho Y, David DJ, Saudou F, Humeau Y, Choquet D., Free PMC Article | 01/5/2019 |
| a circuitry in which the upregulation of miR-409-3p and miR-495-3p, belonging to a brain-specific miRNA subcluster implicated in several neurodevelopmental disorders, produced the downregulation of Gria2, is reported. | A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons.
Capauto D, Colantoni A, Lu L, Santini T, Peruzzi G, Biscarini S, Morlando M, Shneider NA, Caffarelli E, Laneve P, Bozzoni I., Free PMC Article | 12/22/2018 |