| Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis. | Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.
Kondreddy V, Banerjee R, Devi BLAP, Muralidharan K, Piramanayagam S., Free PMC Article | 03/28/2024 |
| Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis. | Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
Habaxi K, Wang W, Taximaimaiti M, Wang L. | 12/20/2023 |
| Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver. | Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver.
Liu N, Sun Q, Xu H, Yu X, Chen W, Wei H, Jiang J, Xu Y, Lu W. | 04/24/2021 |
| ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease. | ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease.
Ichu TA, Reed A, Ogasawara D, Ulanovskaya O, Roberts A, Aguirre CA, Bar-Peled L, Gao J, Germain J, Barbas S, Masuda K, Conti B, Tontonoz P, Cravatt BF., Free PMC Article | 01/23/2021 |
| The role of the small intestine in modulating metabolism and inflammation in atherosclerosis and cancer. | The role of the small intestine in modulating metabolism and inflammation in atherosclerosis and cancer.
Mukherjee P, Chattopadhyay A, Fogelman AM., Free PMC Article | 08/22/2020 |
| LPCAT3 is depleted in non-alcoholic steatohepatitis and leads to caspase-dependent/caspase-independent cell death. | Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis.
Kakisaka K, Suzuki Y, Fujiwara Y, Suzuki A, Kanazawa J, Takikawa Y. | 02/1/2020 |
| LPCAT3 as a key factor in the control of phospholipid homeostasis and arachidonate availability in myeloid cells and its deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis. | LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis.
Thomas C, Jalil A, Magnani C, Ishibashi M, Queré R, Bourgeois T, Bergas V, Ménégaut L, Patoli D, Le Guern N, Labbé J, Gautier T, de Barros JPP, Lagrost L, Masson D. | 10/26/2019 |
| Study show for the first time that LPCAT3 is the major isoform of LPCAT in 3T3L1 pre-adipocytes, and mature adipocytes, as well as mouse adipose tissue, and that LPCAT3 activity-mediated phosphatidylcholine (PC) remodeling affects adipocyte polyunsaturated PC composition, most likely on the cell membrane, thus influencing Wnt/beta-catenin signaling pathway and inhibiting pre-adipocyte differentiation and lipogenesis. | Lysophosphatidylcholine acyltransferase 3 deficiency impairs 3T3L1 cell adipogenesis through activating Wnt/β-catenin pathway.
Feng C, Lou B, Dong J, Li Z, Chen Y, Li Y, Zhang X, Jiang XC, Ding T., Free PMC Article | 12/22/2018 |
| Regulation of LPCAT3 expression might be associated with atherosclerotic progression in humans. | Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.
Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Yata T, Iwaki T, Umemura K, Sano H, Suzuki Y, Urano T, Setou M, Unno N. | 09/9/2017 |
| findings identify LPCAT3 as a direct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid metabolism through LPCAT3. | Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor δ.
Singh AB, Liu J., Free PMC Article | 06/3/2017 |
| small intestine Lpcat3 deficiency has a much bigger effect on plasma lipid levels than that of liver deficiency | Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism.
Kabir I, Li Z, Bui HH, Kuo MS, Gao G, Jiang XC., Free PMC Article | 08/20/2016 |
| LPCAT3 KO mice have longer and larger small intestines than control mice, with shorter wide villi, reduced lipid absorption, and lower levels NPC1L1, CD36, and FATP4 proteins. | Deficiency in lysophosphatidylcholine acyltransferase 3 reduces plasma levels of lipids by reducing lipid absorption in mice.
Li Z, Jiang H, Ding T, Lou C, Bui HH, Kuo MS, Jiang XC., Free PMC Article | 04/9/2016 |
| Data show that the lack of LPCAT3 leads to drastic reductions in membrane arachidonate levels, and that LPCAT3-deficient mice are neonatally lethal due to an extensive triacylglycerol (TG) accumulation and dysfunction in enterocytes. | Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport.
Hashidate-Yoshida T, Harayama T, Hishikawa D, Morimoto R, Hamano F, Tokuoka SM, Eto M, Tamura-Nakano M, Yanobu-Takanashi R, Mukumoto Y, Kiyonari H, Okamura T, Kita Y, Shindou H, Shimizu T., Free PMC Article | 01/30/2016 |
| It is possible that enhanced phospholipid remodeling by LPCAT3 may be associated with adipocyte differentiation. | Lysophosphatidylcholine acyltransferase 3 is the key enzyme for incorporating arachidonic acid into glycerophospholipids during adipocyte differentiation.
Eto M, Shindou H, Koeberle A, Harayama T, Yanagida K, Shimizu T., Free PMC Article | 09/5/2015 |
| hepatic LPCAT3 modulates VLDL production by regulating LysoPC levels and MTP expression. | Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression.
Li Z, Ding T, Pan X, Li Y, Li R, Sanders PE, Kuo MS, Hussain MM, Cao G, Jiang XC., Free PMC Article | 09/22/2012 |