| ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner. | ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner.
Zhao H, Mao H., Free PMC Article | 06/25/2024 |
| GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. | GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.
Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, Peng G, Yu D, Wang B, Tainer JA, Ahmed Z., Free PMC Article | 03/13/2024 |
| Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes. | Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes.
Li X, Liu C, Zhang Z, Li X, Yao Z, Dong Y, Wang X, Chen Z., Free PMC Article | 11/30/2023 |
| GRB2 serves as a viable target against skin fibrosis in systemic sclerosis by regulating endothelial cell apoptosis. | GRB2 serves as a viable target against skin fibrosis in systemic sclerosis by regulating endothelial cell apoptosis.
Huang Y, Zhao H, Shi X, Liu J, Lin JM, Ma Q, Jiang S, Pu W, Ma Y, Liu J, Wu W, Wang J, Liu Q. | 10/10/2023 |
| FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development. | FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development.
Clark JF, Soriano P., Free PMC Article | 09/27/2023 |
| MicroRNA-27a-3p aggravates renal ischemia/reperfusion injury by promoting oxidative stress via targeting growth factor receptor-bound protein 2. | MicroRNA-27a-3p aggravates renal ischemia/reperfusion injury by promoting oxidative stress via targeting growth factor receptor-bound protein 2.
Zhao XR, Zhang Z, Gao M, Li L, Sun PY, Xu LN, Qi Y, Yin LH, Peng JY. | 04/3/2021 |
| Long noncoding RNA AC092171.4 promotes hepatocellular carcinoma progression by sponging microRNA-1271 and upregulating GRB2. | Long noncoding RNA AC092171.4 promotes hepatocellular carcinoma progression by sponging microRNA-1271 and upregulating GRB2.
Sun C, Huang S, Hou Y, Li Z, Xia D, Zhang L, Zhang Y, Cai Y, Wang Z, Zhou Q, He X, Wu L., Free PMC Article | 03/27/2021 |
| Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke. | Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke.
Luo HC, Yi TZ, Huang FG, Wei Y, Luo XP, Luo QS., Free PMC Article | 02/20/2021 |
| we have demonstrated that Grb2 directly interacts with phosphorylated HGAL, collaborating in cSMAC formation while oppositely regulating BCR-induced intracellular biochemical signaling. These interactions may play an important function in regulating the magnitude of BCR signaling and antigen presentation. | Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling.
Jiang X, Lu X, Zhang Y, Lacaria L, Schuchardt BJ, Mikles DC, Magistri M, García-Ramírez I, Sanchez-Garcia I, Farooq A, Verdun RE, Abdulreda MH, Moy VT, Lossos IS., Free PMC Article | 08/1/2020 |
| Gab1 enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner | The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner.
Bongartz H, Gille K, Hessenkemper W, Mandel K, Lewitzky M, Feller SM, Schaper F., Free PMC Article | 07/18/2020 |
| the study identifies a novel pro-fibrotic lncRNA, PCFL, and the mechanism involves the direct interaction of PCFL with miR-378, which in turn relieves the inhibition effect of miR-378 on GRB2 and promotes cardiac fibrosis. | LncRNA PCFL promotes cardiac fibrosis via miR-378/GRB2 pathway following myocardial infarction.
Sun F, Zhuang Y, Zhu H, Wu H, Li D, Zhan L, Yang W, Yuan Y, Xie Y, Yang S, Luo S, Jiang W, Zhang J, Pan Z, Lu Y. | 06/27/2020 |
| GRB2 inhibitors may have the potential to dampen tissue eosinophilia in various eosinophil-associated diseases. | Murine eosinophil development and allergic lung eosinophilia are largely dependent on the signaling adaptor GRB2.
Willebrand R, Dietschmann A, Nitschke L, Krappmann S, Voehringer D. | 04/13/2019 |
| Study shows that growth factor receptor binding protein 2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner. Extrapolating the results of this study to the in vivo conditions, Grb2 should bind the SLP65 transducer module first, and then Vav should associate. | Grb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.
Arya R, Dangi RS, Makwana PK, Kumar A, Upadhyay SK, Sundd M., Free PMC Article | 09/8/2018 |
| Our findings position Grb2 as a key adaptor that integrates various cytokines response in cycling Hematopoietic Stem and Progenitor Cell . | Grb2 regulates the proliferation of hematopoietic stem and progenitors cells.
Frelin C, Ofran Y, Ruston J, Hayun M, Derdikman Y, Khier Y, Rozales K, Brenner B, Iscove N, Pawson T, Louria-Hayon I. | 02/10/2018 |
| Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 activity and Grb2 stability | Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Zvezdova E, Mikolajczak J, Garreau A, Marcellin M, Rigal L, Lee J, Choi S, Blaize G, Argenty J, Familiades J, Li L, Gonzalez de Peredo A, Burlet-Schiltz O, Love PE, Lesourne R. | 12/2/2017 |
| Myogenic differentiation depends on the expression regulation patterns of Grb2 and N-WASP. | Myogenic differentiation depends on the interplay of Grb2 and N-WASP.
Mitra P, Thanabalu T. | 10/7/2017 |
| Two Dtna interactors, alpha-catulin (phosphorylation independent) and Grb2 (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes. | Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction.
Gingras J, Gawor M, Bernadzki KM, Grady RM, Hallock P, Glass DJ, Sanes JR, Proszynski TJ., Free PMC Article | 12/17/2016 |
| Grb2-deficient T cells show defects in T cell development, increased Th1 and Th17 cell differentiation capacities, and impaired proliferation after activation by dendritic cells, which likely reduce the clinical symptoms of EAE. | Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.
Radtke D, Lacher SM, Szumilas N, Sandrock L, Ackermann J, Nitschke L, Zinser E. | 08/6/2016 |
| provide evidence that CD28 and the TCR complex regulate NF-kappaB via different signaling modules of GRB-2/VAV1 and LAT/ADAP pathways respectively. | TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes.
Thaker YR, Schneider H, Rudd CE., Free PMC Article | 09/26/2015 |
| GRB2 physically links cyt-PTPe with Src and enables cyt-PTPe to activate Src downstream of activated integrins in osteoclast-like cells. | Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.
Levy-Apter E, Finkelshtein E, Vemulapalli V, Li SS, Bedford MT, Elson A., Free PMC Article | 04/18/2015 |
| SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1. | SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.
Qu Y, Chen Q, Lai X, Zhu C, Chen C, Zhao X, Deng R, Xu M, Yuan H, Wang Y, Yu J, Huang J., Free PMC Article | 01/17/2015 |
| Data indicate that growth factor receptor protein binding protein 2 (Grb2) is upregulated and regulated by Forkhead Box D3 (Foxd3), and pregulated Grb2 interacts with huntingtin (Htt). | Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin.
Baksi S, Jana NR, Bhattacharyya NP, Mukhopadhyay D., Free PMC Article | 08/9/2014 |
| Grb2 contributes to immunoreceptor tyrosine-based activation motif signaling in platelets during hemostasis and thrombosis. | Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets.
Dütting S, Vögtle T, Morowski M, Schiessl S, Schäfer CM, Watson SK, Hughes CE, Ackermann JA, Radtke D, Hermanns HM, Watson SP, Nitschke L, Nieswandt B., Free PMC Article | 03/29/2014 |
| Findings indicate Grb2 as a new FAK activator and in coordinating PTPalpha tyrosine phosphorylation to enable downstream integrin signaling and migration. | Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.
Cheng SY, Sun G, Schlaepfer DD, Pallen CJ., Free PMC Article | 03/22/2014 |
| Grb2 is not required for the establishment of the glomerular filtration barrier in vivo. | The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.
Bisson N, Ruston J, Jeansson M, Vanderlaan R, Hardy WR, Du J, Hussein SM, Coward RJ, Quaggin SE, Pawson T., Free PMC Article | 06/1/2013 |