| GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway. | GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
Zhou J, Xu W, Wu Y, Wang M, Zhang N, Wang L, Feng Y, Zhang T, Wang L, Mao A. | 11/8/2023 |
| Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling. | Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling.
Bhattacharya P, Dhawan UK, Hussain MT, Singh P, Bhagat KK, Singhal A, Austin-Williams S, Sengupta S, Subramanian M. | 08/3/2023 |
| Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ. | Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ.
Kitamura K, Homma T, Sohel MSH, Fuyuki A, Miyawaki S, Onouchi S, Saito S. | 06/23/2023 |
| Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei. | Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei.
Fuyuki A, Yamamoto S, Sohel MSH, Homma T, Kitamura K, Onouchi S, Saito S., Free PMC Article | 03/9/2023 |
| Inflammation and Infection in Pain and the Role of GPR37. | Inflammation and Infection in Pain and the Role of GPR37.
Zhang Q, Bang S, Chandra S, Ji RR., Free PMC Article | 12/17/2022 |
| Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. | Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications.
Massimi M, Di Pietro C, La Sala G, Matteoni R., Free PMC Article | 04/30/2022 |
| The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice. | The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice.
Veenit V, Zhang X, Ambrosini A, Sousa V, Svenningsson P., Free PMC Article | 02/5/2022 |
| GM1 Is Cytoprotective in GPR37-Expressing Cells and Downregulates Signaling. | GM1 Is Cytoprotective in GPR37-Expressing Cells and Downregulates Signaling.
Hertz E, Saarinen M, Svenningsson P., Free PMC Article | 01/29/2022 |
| GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke. | GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke.
Owino S, Giddens MM, Jiang JG, Nguyen TT, Shiu FH, Lala T, Gearing M, McCrary MR, Gu X, Wei L, Yu SP, Hall RA., Free PMC Article | 10/16/2021 |
| Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. | Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.
Bang S, Donnelly CR, Luo X, Toro-Moreno M, Tao X, Wang Z, Chandra S, Bortsov AV, Derbyshire ER, Ji RR., Free PMC Article | 03/27/2021 |
| In an ischemic stroke model, GPR37 KO mice exhibited increased infarction and cell death compared with wild-type (WT) mice. In the peri-infarct region of GPR37 KO mice, there was significantly more apoptotic and autophagic cell death accompanied by caspase-3 activation and attenuated mechanistic target of rapamycin signaling. | Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice.
McCrary MR, Jiang MQ, Giddens MM, Zhang JY, Owino S, Wei ZZ, Zhong W, Gu X, Xin H, Hall RA, Wei L, Yu SP., Free PMC Article | 06/6/2020 |
| these results revealed the importance of GPR37 regulating A2A R-dependent locomotor sensitization and synaptic plasticity in the basal ganglia circuitry. | Chronic adenosine A(2A) receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice.
Morató X, Gonçalves FQ, Lopes JP, Jauregui O, Soler C, Fernández-Dueñas V, Cunha RA, Ciruela F. | 11/2/2019 |
| findings reveal a previously unrecognized role of GPR37 in regulating MPhi phagocytosis and inflammatory pain resolution. | GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain.
Bang S, Xie YK, Zhang ZJ, Wang Z, Xu ZZ, Ji RR., Free PMC Article | 09/14/2019 |
| this study shows that GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo | The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A(2A) receptor controlling its cell surface expression and function in vivo.
Morató X, Luján R, López-Cano M, Gandía J, Stagljar I, Watanabe M, Cunha RA, Fernández-Dueñas V, Ciruela F., Free PMC Article | 04/13/2019 |
| This studies revealed that Gpr37(-)(/)(-) mice exhibit dramatically increased loss of myelin in response to cuprizone. | Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination.
Smith BM, Giddens MM, Neil J, Owino S, Nguyen TT, Duong D, Li F, Hall RA., Free PMC Article | 04/28/2018 |
| We conclude that GPR37 is crucial for cellular protein quality control during Wnt signaling. | Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.
Berger BS, Acebron SP, Herbst J, Koch S, Niehrs C., Free PMC Article | 01/27/2018 |
| Data suggest that GPR37 regulates central nervous system myelination by controlling the transition from early-differentiated to mature oligodendrocytes. | G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination.
Yang HJ, Vainshtein A, Maik-Rachline G, Peles E., Free PMC Article | 07/30/2016 |
| Knocking-out GPR37 triggers anxiolytic-like effects and regulates hippocampal A2AR-mediated signaling. | The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system.
Lopes JP, Morató X, Souza C, Pinhal C, Machado NJ, Canas PM, Silva HB, Stagljar I, Gandía J, Fernández-Dueñas V, Luján R, Cunha RA, Ciruela F. | 09/12/2015 |
| These data show functional association between GPR37, prosaposin, and GM1 ganglioside in the plasma membrane. | GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability.
Lundius EG, Vukojevic V, Hertz E, Stroth N, Cederlund A, Hiraiwa M, Terenius L, Svenningsson P., Free PMC Article | 04/26/2014 |
| GPR37 knockout mice show age and sex specific improvements in olfaction, increased anxiety and depression-like behaviors. | Mice lacking the Parkinson's related GPR37/PAEL receptor show non-motor behavioral phenotypes: age and gender effect.
Mandillo S, Golini E, Marazziti D, Di Pietro C, Matteoni R, Tocchini-Valentini GP. | 12/14/2013 |
| Macroautophagy of the GPR37 orphan receptor and Parkinson disease-associated neurodegeneration | Macroautophagy of the GPR37 orphan receptor and Parkinson disease-associated neurodegeneration.
Marazziti D, Di Pietro C, Golini E, Mandillo S, Matteoni R, Tocchini-Valentini GP. | 01/21/2010 |
| Data show that GPR37 overexpression can induce cellular autophagy, which may prevent the selective degeneration of GPR37-expressing neurons, as reported for Parkinson's and related neurodegenerative diseases. | Induction of macroautophagy by overexpression of the Parkinson's disease-associated GPR37 receptor.
Marazziti D, Di Pietro C, Golini E, Mandillo S, Matteoni R, Tocchini-Valentini GP. | 01/21/2010 |
| GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs. | GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs.
Marazziti D, Mandillo S, Di Pietro C, Golini E, Matteoni R, Tocchini-Valentini GP., Free PMC Article | 01/21/2010 |
| Upregulation of Pael-R in the substantia nigra pars compacta of mice by retrograde infection induced endoplasmic reticulum (ER) stress leads to death of dopaminergic neurons. | Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation.
Kitao Y, Imai Y, Ozawa K, Kataoka A, Ikeda T, Soda M, Nakimawa K, Kiyama H, Stern DM, Hori O, Wakamatsu K, Ito S, Itohara S, Takahashi R, Ogawa S. | 01/21/2010 |