| Biomarker cystatin B expression correlates with pathogenesis in cervical cancer. | Biomarker cystatin B expression correlates with pathogenesis in cervical cancer.
Ye D, Duan X, Guan B, Yuan J, Zhu Y, Shi J, Lu Q, Xu G., Free PMC Article | 03/26/2024 |
| The Roles of Cystatin B in the Brain and Pathophysiological Mechanisms of Progressive Myoclonic Epilepsy Type 1. | The Roles of Cystatin B in the Brain and Pathophysiological Mechanisms of Progressive Myoclonic Epilepsy Type 1.
Singh S, Hämäläinen RH., Free PMC Article | 02/9/2024 |
| Decreased CSTB, RAGE, and Axl Receptor Are Associated with Zika Infection in the Human Placenta. | Decreased CSTB, RAGE, and Axl Receptor Are Associated with Zika Infection in the Human Placenta.
Borges-Vélez G, Arroyo JA, Cantres-Rosario YM, Rodriguez de Jesus A, Roche-Lima A, Rosado-Philippi J, Rosario-Rodríguez LJ, Correa-Rivas MS, Campos-Rivera M, Meléndez LM., Free PMC Article | 12/3/2022 |
| Brief Report: Intracellular Cystatin B Levels Are Altered in HIV-Infected Participants With Respect to Neurocognitive Status and Antiretroviral Therapy. | Brief Report: Intracellular Cystatin B Levels Are Altered in HIV-Infected Participants With Respect to Neurocognitive Status and Antiretroviral Therapy.
Opsteen S, Moylan D, Taiwo BO, Robertson KR, Overton ET, Cutter GR, Sabbaj S, Heath SL, Shacka JJ., Free PMC Article | 11/19/2022 |
| The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer. | The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer.
Huang C, Ai X, Hu L, Ren D., Free PMC Article | 06/11/2022 |
| Evaluation of CSTB and DMBT1 expression in saliva of gastric cancer patients and controls. | Evaluation of CSTB and DMBT1 expression in saliva of gastric cancer patients and controls.
Koopaie M, Ghafourian M, Manifar S, Younespour S, Davoudi M, Kolahdooz S, Shirkhoda M., Free PMC Article | 05/14/2022 |
| Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy. | Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy.
Di Matteo F, Pipicelli F, Kyrousi C, Tovecci I, Penna E, Crispino M, Chambery A, Russo R, Ayo-Martin AC, Giordano M, Hoffmann A, Ciusani E, Canafoglia L, Götz M, Di Giaimo R, Cappello S., Free PMC Article | 09/18/2021 |
| Genetic testing and the phenotype of Polish patients with Unverricht-Lundborg disease (EPM1) - A cohort study. | Genetic testing and the phenotype of Polish patients with Unverricht-Lundborg disease (EPM1) - A cohort study.
Bosak M, Sułek A, Łukasik M, Żak A, Słowik A, Lasek-Bal A. | 05/1/2021 |
| The findings suggest that the cleaved Bid protein acts as an amplifier of apoptotic signaling through mitochondria, thus enhancing the activity of cysteine cathepsins following stefin B degradation. | Menadione-induced apoptosis in U937 cells involves Bid cleavage and stefin B degradation.
Božič J, Bidovec K, Vizovišek M, Dolenc I, Stoka V. | 07/25/2020 |
| CSTB was overexpressed and miR1433p was downregulated in ovarian malignant tumors. Mature miR1433p directly bound CSTB 3'UTR, leading to a decrease in CSTB expression in OC cells, which was regulated by TGFbeta1. | Transforming growth factor‑β/miR‑143‑3p/cystatin B axis is a therapeutic target in human ovarian cancer.
Guan W, Wang X, Lin Q, Zhang J, Ren W, Xu G. | 10/5/2019 |
| While novel diagnostic tumour markers are urgently needed, the examined potential tumour markers, with the exception of PIVKAII seem to be inadequate for diagnosing HCC in ALC | Diagnostic specificity and sensitivity of PIVKAII, GP3, CSTB, SCCA1 and HGF for the diagnosis of hepatocellular carcinoma in patients with alcoholic liver cirrhosis.
Unić A, Derek L, Duvnjak M, Patrlj L, Rakić M, Kujundžić M, Renjić V, Štoković N, Dinjar P, Jukic A, Grgurević I. | 01/26/2019 |
| cystatin B expression was significantly and inversely correlated with lung tumor stage and tumor grade | Expression and epigenetic regulation of cystatin B in lung cancer and colorectal cancer.
Ma Y, Chen Y, Petersen I. | 08/11/2018 |
| The results demonstrate that cystatin B interferes with the STAT-1 signaling and IFN-beta-antiviral responses perpetuating HIV in macrophage reservoirs. | Cystatin B and HIV regulate the STAT-1 signaling circuit in HIV-infected and INF-β-treated human macrophages.
Rivera LE, Kraiselburd E, Meléndez LM., Free PMC Article | 01/27/2018 |
| apoptosis is accompanied by degradation of the cysteine cathepsin inhibitor stefin B (StfB). CatD did not exhibit a crucial role in this step. However, this degradation was partially prevented through pre-incubation with the antioxidant N-acetyl cysteine | Tumor Necrosis Factor-α Induced Apoptosis in U937 Cells Promotes Cathepsin D-Independent Stefin B Degradation.
Bidovec K, Božič J, Dolenc I, Turk B, Turk V, Stoka V. | 01/6/2018 |
| Homozygous for a c.218dupT (p.His75Serfs*2) mutation in exon 3 of CSTB causes neurodegeneration, progressive cerebral volume loss and diffuse hypomyelination. | Severe neurodegeneration, progressive cerebral volume loss and diffuse hypomyelination associated with a homozygous frameshift mutation in CSTB.
O'Brien A, Marshall CR, Blaser S, Ray PN, Yoon G., Free PMC Article | 09/16/2017 |
| CSTB downregulation may promote the development of gastric cancer. | CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line.
Zhang J, Shi Z, Huang J, Zou X., Free PMC Article | 03/25/2017 |
| It was shown that decreased expression of cystatin B enhances cathepsin activity in Niemann-Pick C cerebellar degeneration patient fibroblasts. | Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration.
Chung C, Puthanveetil P, Ory DS, Lieberman AP., Free PMC Article | 01/28/2017 |
| High expression of stefin B may be an important factor contributing to the development and metastasis of Hepatocellular Carcinoma. | Tissue Levels of Stefin A and Stefin B in Hepatocellular Carcinoma.
Lin YY, Chen ZW, Lin ZP, Lin LB, Yang XM, Xu LY, Xie Q. | 12/17/2016 |
| CSTB null mutation associated with microcephaly, early developmental delay, and severe dyskinesia. | CSTB null mutation associated with microcephaly, early developmental delay, and severe dyskinesia.
Mancini GM, Schot R, de Wit MC, de Coo RF, Oostenbrink R, Bindels-de Heus K, Berger LP, Lequin MH, de Vries FA, Wilke M, van Slegtenhorst MA. | 07/16/2016 |
| Data shows that CYTB and ANXA4 overexpression may be involved in carcinogenesis and histopathological differentiation of ovarian clear cell carcinoma and suggest they may serve as a potential diagnostic biomarkers. | Cystatin B as a potential diagnostic biomarker in ovarian clear cell carcinoma.
Takaya A, Peng WX, Ishino K, Kudo M, Yamamoto T, Wada R, Takeshita T, Naito Z. | 12/12/2015 |
| A role for disease-causing mutations in cystatin B gene in patients with juvenile myoclonic epilepsy was not supported. | No evidence of a role for cystatin B gene in juvenile myoclonic epilepsy.
Mumoli L, Tarantino P, Michelucci R, Bianchi A, Labate A, Franceschetti S, Marini C, Striano P, Gagliardi M, Ferlazzo E, Sofia V, Pennese L, Annesi G, Aguglia U, Guerrini R, Zara F, Gambardella A, Genetic Commission, Italian League Against Epilepsy. | 06/20/2015 |
| Even though the majority of EPM1 patients have a uniform genetic mutation, the actual size of the longer CSTB expansion mutation allele is likely to have a modulating effect on the age at disease onset, myoclonus severity, and cortical neurophysiology. | Refining the phenotype of Unverricht-Lundborg disease (EPM1): a population-wide Finnish study.
Hyppönen J, Äikiä M, Joensuu T, Julkunen P, Danner N, Koskenkorva P, Vanninen R, Lehesjoki AE, Mervaala E, Kälviäinen R. | 06/20/2015 |
| The study shows detection of stefin B dimers in HEK293 cells and the importance of their residual activity. | Human stefin B role in cell's response to misfolded proteins and autophagy.
Polajnar M, Zavašnik-Bergant T, Škerget K, Vizovišek M, Vidmar R, Fonović M, Kopitar-Jerala N, Petrovič U, Navarro S, Ventura S, Žerovnik E., Free PMC Article | 04/11/2015 |
| glutamate dehydrogenase is a euchromatin-associated enzyme, and its H3 clipping activity is regulated by chromatin structure, histone modifications and an in vivo inhibitor. | H3 clipping activity of glutamate dehydrogenase is regulated by stefin B and chromatin structure.
Mandal P, Chauhan S, Tomar RS. | 01/31/2015 |
| detected a homozygous expansion of dodecamer repeats in the CSTB gene in four patients with clinical diagnosis of ULD. | A shared haplotype indicates a founder event in Unverricht-Lundborg disease patients from Serbia.
Kecmanović M, Ristić AJ, Ercegovac M, Keckarević-Marković M, Keckarević D, Sokić D, Romac S. | 01/10/2015 |