| Seipin is involved in oxygen-glucose deprivation/reoxygenation induced neuroinflammation by regulating the TLR3/TRAF3/NF-kappaB pathway. | Seipin is involved in oxygen-glucose deprivation/reoxygenation induced neuroinflammation by regulating the TLR3/TRAF3/NF-κB pathway.
Guo D, Hu L, Xie P, Sun P, Yu W. | 06/10/2024 |
| Effects of Seipin on Mouse Mesenchymal Stem Cell Osteo-Adipogenic Balance. | Effects of Seipin on Mouse Mesenchymal Stem Cell Osteo-Adipogenic Balance.
Li Z, Jin S, Xu T, Chen H, Cai W, Du J, Qiu J, Zhuang S, Qi Y, Gu W, Pang L. | 04/11/2024 |
| Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization. | Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization.
Shen WJ, Cortez Y, Singh A, Chen W, Azhar S, Kraemer FB., Free PMC Article | 03/8/2023 |
| BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism. | BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism.
Zhou H, Li J, Su H, Li J, Lydic TA, Young ME, Chen W., Free PMC Article | 04/9/2022 |
| Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes. | Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes.
Combot Y, Salo VT, Chadeuf G, Hölttä M, Ven K, Pulli I, Ducheix S, Pecqueur C, Renoult O, Lak B, Li S, Karhinen L, Belevich I, Le May C, Rieusset J, Le Lay S, Croyal M, Tayeb KS, Vihinen H, Jokitalo E, Törnquist K, Vigouroux C, Cariou B, Magré J, Larhlimi A, Ikonen E, Prieur X. | 02/19/2022 |
| Berardinelli-Seip congenital lipodystrophy 2/SEIPIN determines brown adipose tissue maintenance and thermogenic programing. | Berardinelli-Seip congenital lipodystrophy 2/SEIPIN determines brown adipose tissue maintenance and thermogenic programing.
Zhou H, Xu C, Lee H, Yoon Y, Chen W., Free PMC Article | 07/3/2021 |
| Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy. | Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy.
Mcilroy GD, Mitchell SE, Han W, Delibegović M, Rochford JJ., Free PMC Article | 11/21/2020 |
| Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy. | Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy.
Zhou H, Lei X, Yan Y, Lydic T, Li J, Weintraub NL, Su H, Chen W., Free PMC Article | 09/26/2020 |
| the effects of SEIPIN on triglyceride and PGC-1alpha are dependent on calcium concentrations, signifying regulatory activity on hepatic lipometabolism through alterations in the intracellular calcium level. | SEIPIN overexpression in the liver may alleviate hepatic steatosis by influencing the intracellular calcium level.
Li Q, Li Y, Zhang Z, Kang H, Zhang L, Zhang Y, Zhou L. | 01/18/2020 |
| neuronal seipin deletion causes hyperphosphorylation and aggregation of tau protein leading to axonal atrophy through reduced PPARgamma to enhance GSK3beta and Akt/mTOR signaling; systemic seipin deletion-induced insulin resistance causes tau hyperphosphorylation via cascading JNK pathway. | Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance.
Chang H, Di T, Wang Y, Zeng X, Li G, Wan Q, Yu W, Chen L. | 01/11/2020 |
| Study links BSCL2 lipodystrophy to reduced triglycerides but excess glycogen in hypertrophic skeletal muscle. Incomplete fatty acid oxidation in muscle of Bscl2-/- mice results in insulin resistance, while hyperinsulinemia may trigger excessive muscle glycogen synthesis and growth. Also, circulating fatty acids level in BSCL2 lipodystrophy are a key determinant of oxidative muscle insulin sensitivity and glucose uptake. | Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice.
Xu W, Zhou H, Xuan H, Saha P, Wang G, Chen W., Free PMC Article | 11/16/2019 |
| results indicate that seipin deficiency causes an age-related loss of dopaminergic neurons and impairment of motor coordination through reducing PPARgamma to enhance aggregation and phosphorylation of alphaSyn and neuroinflammation. | Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation.
Wang L, Hong J, Wu Y, Liu G, Yu W, Chen L., Free PMC Article | 11/9/2019 |
| These findings provide further evidence that loss of Bscl2 in non-adipose tissues may contribute to the severity of metabolic dysfunction in this condition. | Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet.
Mcilroy GD, Mitchell SE, Han W, Delibegović M, Rochford JJ., Free PMC Article | 10/26/2019 |
| This study demonstrates increased ER stress and apoptosis in LD1 Bscl2-/- mammary gland alveolar epithelial cells and reveals a novel in vivo function of seipin in lactation. | Seipin deficiency leads to increased endoplasmic reticulum stress and apoptosis in mammary gland alveolar epithelial cells during lactation.
El Zowalaty AE, Li R, Chen W, Ye X., Free PMC Article | 08/3/2019 |
| Renal injury in Seipin-deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue-kidney crosstalk. | Renal injury in Seipin-deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue-kidney crosstalk.
Liu XJ, Wu XY, Wang H, Wang SX, Kong W, Zhang L, Liu G, Huang W. | 04/6/2019 |
| Bscl2 knockout causes significant reduction in adipose mass and altered fuel utilization without overt metabolic dysfunction. | Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease.
Mcilroy GD, Suchacki K, Roelofs AJ, Yang W, Fu Y, Bai B, Wallace RJ, De Bari C, Cawthorn WP, Han W, Delibegović M, Rochford JJ., Free PMC Article | 03/16/2019 |
| there is a potential role of seipin in regulating autophagy in uterine luminal epithelium but not myometrium | Seipin deficiency leads to defective parturition in mice.
Zowalaty AEE, Ye X., Free PMC Article | 06/30/2018 |
| we show that seipin knockdown had very little effect on adipocyte differentiation without affecting insulin sensitivity and oxygen consumption. | Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode.
Dollet L, Magré J, Joubert M, Le May C, Ayer A, Arnaud L, Pecqueur C, Blouin V, Cariou B, Prieur X., Free PMC Article | 04/28/2018 |
| Although the severity of adipose loss in female and male Seipin(-/-)apoE(-/-) mice were similar, hyperlipidemia, steatohepatitis and atherosclerosis were less severe in females than in males. | Dyslipidemia, steatohepatitis and atherogenesis in lipodystrophic apoE deficient mice with Seipin deletion.
Liao J, Liu X, Gao M, Wang M, Wang Y, Wang F, Huang W, Liu G. | 03/3/2018 |
| These data identify SEIPIN as an evolutionarily conserved regulator of microsomal GPAT. | SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase.
Pagac M, Cooper DE, Qi Y, Lukmantara IE, Mak HY, Wu Z, Tian Y, Liu Z, Lei M, Du X, Ferguson C, Kotevski D, Sadowski P, Chen W, Boroda S, Harris TE, Liu G, Parton RG, Huang X, Coleman RA, Yang H., Free PMC Article | 11/26/2017 |
| Seipin deficiency in astrocytes increases GSK3beta activity and levels of IL-6 and TNF-alpha through reducing PPARgamma, which can facilitate Abeta25-35/1-42-induced neuroinflammation to cause the death of neuronal cells and cognitive deficits. | Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse.
Qian Y, Yin J, Hong J, Li G, Zhang B, Liu G, Wan Q, Chen L., Free PMC Article | 10/14/2017 |
| Study found more nuclei positive for SEIPIN than shown using in situ hybridization and confirmed the presence of SEIPIN in neurons projecting to the spinal cord. | The expression of SEIPIN in the mouse central nervous system.
Liu X, Xie B, Qi Y, Du X, Wang S, Zhang Y, Paxinos G, Yang H, Liang H. | 10/14/2017 |
| Findings reveal a key cell-autonomous role for BSCL2 in controlling brown adipose tissue mass and activity. | Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function.
Zhou H, Black SM, Benson TW, Weintraub NL, Chen W., Free PMC Article | 05/20/2017 |
| Our findings reveal that seipin knockout exacerbates cerebral I/R-induced damages by increasing BBB permeability, amplifying ER stress and increasing glucose levels, as well as decreasing leptin and adiponectin levels, indicating that seipin may be a potential therapeutic target for stroke. | Seinpin knockout exacerbates cerebral ischemia/reperfusion damage in mice.
Chen Y, Wei L, Tian J, Wang YH, Liu G, Wang C. | 05/13/2017 |
| The results indicate that, by reducing PPARgamma, seipin deficiency impairs proliferation and differentiation of neural stem and progenitor cells. | Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ.
Li G, Zhou L, Zhu Y, Wang C, Sha S, Xian X, Ji Y, Liu G, Chen L., Free PMC Article | 09/17/2016 |