| L-DOPA Receptor GPR143 Functionally Couples with Adrenergic alpha1B Receptor at the Second Transmembrane Interface. | L-DOPA Receptor GPR143 Functionally Couples with Adrenergic α(1B) Receptor at the Second Transmembrane Interface.
Masukawa D, Takahagi R, Nakao Y, Goshima Y. | 10/20/2023 |
| PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant alpha1B-adrenergic receptors. | PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant α(1B)-adrenergic receptors.
Renkhold L, Kollmann R, Inderwiedenstraße L, Kienitz MC. | 04/9/2022 |
| Tumor necrosis factor alpha induces alpha1B-adrenergic receptor expression in keratinocytes. | Tumor necrosis factor α induces α(1B)-adrenergic receptor expression in keratinocytes.
Wijaya LK, Stumbles PA, Drummond PD. | 05/22/2021 |
| Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and alpha1-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays. | Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α(1)-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays.
Gao X, Enten GA, DeSantis AJ, Volkman BF, Gaponenko V, Majetschak M., Free PMC Article | 01/16/2021 |
| Study data indicate that GRK2 and RAB5 play key roles in alpha1B-adrenergic receptor phosphorylation, internalization, and desensitization. The possibility that RAB5 might form part of a signaling complex is suggested, as well as that GDP-Rab5 might interfere with the ability of GRK2 to catalyze alpha1B-adrenergic receptor phosphorylation. | Roles of the G protein-coupled receptor kinase 2 and Rab5 in α(1B)-adrenergic receptor function and internalization.
Hernández-Espinosa DA, Reyes-Cruz G, García-Sáinz JA. | 06/13/2020 |
| The association of variants in the ADRA1B gene with psoriasis could explain why variants in the IL-12B, ADRA1B and PTTG1 gene regions are associated with psoriasis. | Fine mapping and subphenotyping implicates ADRA1B gene variants in psoriasis susceptibility in a Chinese population.
Fan X, Wang H, Sun L, Zheng X, Yin X, Zuo X, Peng Q, Standish KA, Cheng H, Zhang Y, Wang Z, Xiao F, Yang S, Zhang X, Schork NJ., Free PMC Article | 05/23/2020 |
| Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the alpha1B- and beta2-adrenoceptors. | Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α(1B)- and β(2)-adrenoceptors.
Ragnarsson L, Andersson Å, Thomas WG, Lewis RJ. | 05/16/2020 |
| ADRA1 expression was greater on vascular smooth muscle in burn scars than in unscarred tissue, and greater on dermal nerve fibres, blood vessels and fibroblasts in keloid scars than in either burn scars or unscarred skin. | Up-regulation of α(1)-adrenoceptors in burn and keloid scars.
Drummond PD, Dawson LF, Wood FM, Fear MW. | 03/16/2019 |
| Hetero-oligomerization of a1B/D-adrenergic receptor with the chemokine (C-X-C motif) receptor 4:atypical chemokine receptor 3 heteromeric complex is required for a1B/Dadrenergic receptor function. | α(1)-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells.
Albee LJ, Eby JM, Tripathi A, LaPorte HM, Gao X, Volkman BF, Gaponenko V, Majetschak M., Free PMC Article | 06/16/2018 |
| ADRA1B rs10070745 was significantly associated with vasoconstrictor responses. | Genetic variation in the alpha(1B)-adrenergic receptor and vascular response.
Adefurin A, Ghimire LV, Kohli U, Muszkat M, Sofowora GG, Li C, Levinson RT, Paranjape SY, Stein CM, Kurnik D., Free PMC Article | 04/21/2018 |
| Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.( | Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.
Kienitz MC, Vladimirova D, Müller C, Pott L, Rinne A., Free PMC Article | 06/3/2017 |
| protein kinase C modulates alpha1B-adrenergic receptor transfer to late endosomes and that Rab9 regulates this process and participates in G protein-mediated signaling turn-off. | Protein Kinase C Activation Promotes α(1B)-Adrenoceptor Internalization and Late Endosome Trafficking through Rab9 Interaction. Role in Heterologous Desensitization.
Alfonzo-Méndez MA, Hernández-Espinosa DA, Carmona-Rosas G, Romero-Ávila MT, Reyes-Cruz G, García-Sáinz JA. | 05/13/2017 |
| eIF3f/alpha adrenergic receptor interaction | The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity.
Gutiérrez-Fernández MJ, Higareda-Mendoza AE, Gómez-Correa CA, Pardo-Galván MA., Free PMC Article | 01/30/2016 |
| alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts. | The stimulatory effects of alpha1-adrenergic receptors on TGF-beta1, IGF-1 and hyaluronan production in human skin fibroblasts.
Liao MH, Liu SS, Peng IC, Tsai FJ, Huang HH. | 09/5/2015 |
| heteromeric receptor complexes between alpha1A-AR and CXCR4 and between alpha1B-AR and CXCR4 are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction | Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.
Tripathi A, Vana PG, Chavan TS, Brueggemann LI, Byron KL, Tarasova NI, Volkman BF, Gaponenko V, Majetschak M., Free PMC Article | 06/27/2015 |
| Mean alpha-receptor stain rates in renal pelvis were 2.65 +/- 0.74, 1.35 +/- 0.81 and 2.9 +/- 0.30 for alpha 1A, 1B and 1D, respectively. For calyces, the rates are 2.40 +/- 0.82, 1.50 +/- 0.76 and 2.75 +/- 0.44 for alpha 1A, 1B and 1D, respectively. | The presence and distribution of alpha adrenergic receptors in human renal pelvis and calyces.
Karabacak OR, Yilmazer D, Ozturk U, Sener NC, Saltas H, Karabacak Y, Alper M. | 06/7/2014 |
| alpha1B-AR signals through calcium, ERK1/2 and p38 only when located in the membrane and the signals disappear by membrane disruption. | Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targeting.
Segura V, Pérez-Aso M, Montó F, Carceller E, Noguera MA, Pediani J, Milligan G, McGrath IC, D'Ocon P., Free PMC Article | 11/30/2013 |
| A rare ADRA1B haplotype composed of six single nucleotide polymorphism(SNP)s is associated with attention deficit hyperactivity disorder (ADHD). | A high density linkage disequilibrium mapping in 14 noradrenergic genes: evidence of association between SLC6A2, ADRA1B and ADHD.
Hawi Z, Matthews N, Barry E, Kirley A, Wagner J, Wallace RH, Heussler HS, Vance A, Gill M, Bellgrove MA. | 10/19/2013 |
| Noradrenaline facilitated cell proliferation by regulation of potassium currents in human osteoblasts via G(i/o) -protein-coupled alpha(1B) -adrenoceptors, not via coupling to Gq-proteins | Noradrenaline stimulates cell proliferation by suppressing potassium channels via G(i/o) -protein-coupled α(1B) -adrenoceptors in human osteoblasts.
Kodama D, Togari A., Free PMC Article | 08/31/2013 |
| Through beta-D receptor heteromers dopamine inhibits adrenergic receptor signaling and blocks the synthesis of melatonin induced by adrenergic receptor ligands. | Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.
González S, Moreno-Delgado D, Moreno E, Pérez-Capote K, Franco R, Mallol J, Cortés A, Casadó V, Lluís C, Ortiz J, Ferré S, Canela E, McCormick PJ., Free PMC Article | 10/13/2012 |
| Data show that sphingosine 1-phosphate can induce alpha1B-adrenergic receptor internalization and that its autocrine/paracrine generation is relevant for internalization induced by IGF-I. | Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions.
Castillo-Badillo JA, Molina-Muñoz T, Romero-Ávila MT, Vázquez-Macías A, Rivera R, Chun J, García-Sáinz JA., Free PMC Article | 05/12/2012 |
| alpha1b and alpha2c AR is over-expressed in basal-like breast tumours of poor prognosis | Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study.
Powe DG, Voss MJ, Habashy HO, Zänker KS, Green AR, Ellis IO, Entschladen F. | 02/11/2012 |
| The mRNA expression of alpha1b-AR subtypes in bladder detrusor and posterior urethra was significantly lower in the inflammation group than in controls. | [Distribution and significance of α1-adrenoceptor subtypes in patients with chronic prostatitis in prostate, bladder detrusor and posterior urethral tissue].
Yang Y, Xie H, Zheng JJ, Chen BC, He QX, Shen JH. | 09/17/2011 |
| A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation. | A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activation.
Cariolato L, Cavin S, Diviani D., Free PMC Article | 05/14/2011 |
| These results are the first to demonstrate alpha1-ARs on human coronary ECs and indicate that the alpha1B subtype is predominant. | Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.
Jensen BC, Swigart PM, Montgomery MD, Simpson PC., Free PMC Article | 03/26/2011 |