| Specific regulation of mechanical nociception by Gbeta5 involves GABA-B receptors. | Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors.
Pandey M, Zhang JH, Adikaram PR, Kittock C, Lue N, Awe A, Degner K, Jacob N, Staples J, Thomas R, Kohnen AB, Ganesan S, Kabat J, Chen CK, Simonds WF., Free PMC Article | 07/12/2023 |
| The regulatory G protein signaling complex, Gbeta5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion. | The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.
Wang Q, Henry TAN, Pronin AN, Jang GF, Lubaczeuski C, Crabb JW, Bernal-Mizrachi E, Slepak VZ., Free PMC Article | 12/26/2020 |
| Stimulation of the ERK pathway in Gnb5(-/-) cells by epidermal growth factor restored M3R-stimulated insulin release to near normal levels. Identification of the novel role of Gbeta5-R7 in insulin secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function | Regulator of G-protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion.
Wang Q, Pronin AN, Levay K, Almaca J, Fornoni A, Caicedo A, Slepak VZ., Free PMC Article | 11/25/2017 |
| The complex of G protein regulator RGS9-2 and Gbeta(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum. | The complex of G protein regulator RGS9-2 and Gβ(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum.
Xie K, Masuho I, Brand C, Dessauer CW, Martemyanov KA., Free PMC Article | 01/12/2013 |
| Expression of the Gbeta5/R7-RGS protein complex in pituitary and pancreatic islet cells. | Expression of the Gβ5/R7-RGS protein complex in pituitary and pancreatic islet cells.
Nini L, Zhang JH, Pandey M, Panicker LM, Simonds WF., Free PMC Article | 12/22/2012 |
| Gbeta5/RGS6 (guanine nucleotide binding protein beta5/regulator of G-protein signaling 6) complex modulates timing of parasympathetic influence on atrial myocytes and heart rate. | RGS6/Gβ5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate.
Posokhova E, Wydeven N, Allen KL, Wickman K, Martemyanov KA., Free PMC Article | 10/9/2012 |
| Elimination of Gbeta5-RGS complexes led to a striking level of hyperactivity that far exceeds activity levels previously observed in animal models. | Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems.
Xie K, Ge S, Collins VE, Haynes CL, Renner KJ, Meisel RL, Lujan R, Martemyanov KA., Free PMC Article | 09/29/2012 |
| We conclude that even a partial reduction in Gbeta5-R7 level can perturb normal animal metabolism and behavior. | Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice.
Wang Q, Levay K, Chanturiya T, Dvoriantchikova G, Anderson KL, Bianco SD, Ueta CB, Molano RD, Pileggi A, Gurevich EV, Gavrilova O, Slepak VZ., Free PMC Article | 12/31/2011 |
| Gbeta5 regulates dendritic arborization and/or synapse formation during development, in part by effects on gene expression; mice lacking Gbeta5 have a markedly abnormal neurologic phenotype. | Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice.
Zhang JH, Pandey M, Seigneur EM, Panicker LM, Koo L, Schwartz OM, Chen W, Chen CK, Simonds WF., Free PMC Article | 12/3/2011 |
| regulator of G-protein signalling 7 binding protein contributes significantly to the nuclear localization of endogenous G beta(5)/R7-RGS complex in brain | Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein.
Panicker LM, Zhang JH, Posokhova E, Gastinger MJ, Martemyanov KA, Simonds WF., Free PMC Article | 07/12/2010 |
| study found that RGS7-Gbeta5 complexes bound to G protein-gated potassium channels and facilitated their functional coupling to GABA(B) receptors in neurons | Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling.
Xie K, Allen KL, Kourrich S, Colón-Saez J, Thomas MJ, Wickman K, Martemyanov KA., Free PMC Article | 06/28/2010 |
| Gbeta5 and R7BP in striatum undergo remodeling upon changes in neuronal activity. | Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits.
Anderson GR, Lujan R, Martemyanov KA., Free PMC Article | 01/21/2010 |
| Delivery of RGS7/Gbeta5 to dendrites of ON-bipolar cells occurs independently of its association with R7BP. These findings provide a new mechanism for adapter-independent targeting of RGS/Gbeta5 complexes. | Targeting of RGS7/Gbeta5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP.
Cao Y, Song H, Okawa H, Sampath AP, Sokolov M, Martemyanov KA., Free PMC Article | 01/21/2010 |
| R7-Gbeta5-R7BP complexes in the mouse could regulate signaling by modulatory Gi/o-coupled GPCRs in the developing and adult nervous systems. | Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gbeta5 complexes in brain.
Grabowska D, Jayaraman M, Kaltenbronn KM, Sandiford SL, Wang Q, Jenkins S, Slepak VZ, Smith Y, Blumer KJ., Free PMC Article | 01/21/2010 |
| G-protein beta5 short splice variant isoform is indispensable for outer plexiform layer integrity and normal light responses of the retina. | Gbeta5 is required for normal light responses and morphology of retinal ON-bipolar cells.
Rao A, Dallman R, Henderson S, Chen CK., Free PMC Article | 01/21/2010 |
| Disruption of the Gbeta5 gene in mice abolishes expression of Gbeta5-L in the retina and also greatly reduces the expression level of RGS9-1, indicating a complex containing RGS9-1-Gbeta5-L is essential for normal G-protein deactivation and rod function | Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice.
Krispel CM, Chen CK, Simon MI, Burns ME., Free PMC Article | 01/21/2010 |
| photoreceptors R9AP determines the stability of the RGS9.Gbeta5 complex, and therefore all three proteins, RGS9, Gbeta5 , and R9AP, are obligate members of the regulatory complex that speeds the rate at which transducin hydrolyzes GTP. | Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse.
Keresztes G, Martemyanov KA, Krispel CM, Mutai H, Yoo PJ, Maison SF, Burns ME, Arshavsky VY, Heller S. | 01/21/2010 |