| Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome. | Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome.
Zhu P, Bi X, Su D, Li X, Chen Y, Song Z, Zhao L, Wang Y, Xu S, Wu X. | 10/18/2024 |
| A mammalian-specific Alex3/Galphaq protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival. | A mammalian-specific Alex3/Gα(q) protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival.
Izquierdo-Villalba I, Mirra S, Manso Y, Parcerisas A, Rubio J, Del Valle J, Gil-Bea FJ, Ulloa F, Herrero-Lorenzo M, Verdaguer E, Benincá C, Castro-Torres RD, Rebollo E, Marfany G, Auladell C, Navarro X, Enríquez JA, López de Munain A, Soriano E, Aragay AM. | 02/14/2024 |
| A regulatory node involving Galphaq, PLCbeta, and RGS proteins modulates platelet reactivity to critical agonists. | A regulatory node involving Gα(q), PLCβ, and RGS proteins modulates platelet reactivity to critical agonists.
Gupta S, Cooper M, Zhao X, Yarman Y, Thomson H, DeHelian D, Brass LF, Ma P., | 12/15/2023 |
| Developmental expression of the Sturge-Weber syndrome-associated genetic mutation in Gnaq: a formal test of Happle's paradominant inheritance hypothesis. | Developmental expression of the Sturge-Weber syndrome-associated genetic mutation in Gnaq: a formal test of Happle's paradominant inheritance hypothesis.
Wetzel-Strong SE, Galeffi F, Benavides C, Patrucco M, Bullock JL, Gallione CJ, Lee HK, Marchuk DA., Free PMC Article | 08/10/2023 |
| Activation of PTH1R alleviates epididymitis and orchitis through Gq and beta-arrestin-1 pathways. | Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways.
Wang MW, Yang Z, Chen X, Zhou SH, Huang GL, Sun JN, Jiang H, Xu WM, Lin HC, Yu X, Sun JP., Free PMC Article | 12/18/2021 |
| Sex and brain region-specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice. | Sex and brain region-specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice.
Haase J, Jones AKC, Mc Veigh CJ, Brown E, Clarke G, Ahnert-Hilger G. | 11/22/2021 |
| Endothelin signaling promotes melanoma tumorigenesis driven by constitutively active GNAQ. | Endothelin signaling promotes melanoma tumorigenesis driven by constitutively active GNAQ.
Jain F, Longakit A, Huang JL, Van Raamsdonk CD. | 08/14/2021 |
| Galphaq activation modulates autophagy by promoting mTORC1 signaling. | Gαq activation modulates autophagy by promoting mTORC1 signaling.
Cabezudo S, Sanz-Flores M, Caballero A, Tasset I, Rebollo E, Diaz A, Aragay AM, Cuervo AM, Mayor F Jr, Ribas C., Free PMC Article | 08/7/2021 |
| Gqalpha/G11alpha deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity. | G(q)α/G(11)α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.
Wilson EA, Sun H, Cui Z, Jahnke MT, Pandey M, Metzger P, Gavrilova O, Chen M, Weinstein LS., Free PMC Article | 03/6/2021 |
| Gs/Gq signaling switch in beta cells defines incretin effectiveness in diabetes. | Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes.
Oduori OS, Murao N, Shimomura K, Takahashi H, Zhang Q, Dou H, Sakai S, Minami K, Chanclon B, Guida C, Kothegala L, Tolö J, Maejima Y, Yokoi N, Minami Y, Miki T, Rorsman P, Seino S., Free PMC Article | 02/20/2021 |
| The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects. | The orphan receptor GPR139 signals via G(q/11) to oppose opioid effects.
Stoveken HM, Zucca S, Masuho I, Grill B, Martemyanov KA., Free PMC Article | 01/16/2021 |
| GNAQ(Q209L) expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system. | GNAQ(Q209L) expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.
Urtatiz O, Cook C, Huang JL, Yeh I, Van Raamsdonk CD. | 11/21/2020 |
| Recurrent somatic GNAQ T96S mutations contribute to the pathogenesis of natural killer/T cell lymphoma. | Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma.
Li Z, Zhang X, Xue W, Zhang Y, Li C, Song Y, Mei M, Lu L, Wang Y, Zhou Z, Jin M, Bian Y, Zhang L, Wang X, Li L, Li X, Fu X, Sun Z, Wu J, Nan F, Chang Y, Yan J, Yu H, Feng X, Wang G, Zhang D, Fu X, Zhang Y, Young KH, Li W, Zhang M., Free PMC Article | 01/11/2020 |
| compartmentalization of G protein-coupled receptors that signal through Galphaq dictate activation of ERK and cardiac myocyte survival in adult cardiac myocytes. | ERK mediated survival signaling is dependent on the Gq-G-protein coupled receptor type and subcellular localization in adult cardiac myocytes.
Dahl EF, Wu SC, Healy CL, Perry J, O'Connell TD. | 01/11/2020 |
| The authors demonstrated that the ubiquitous G protein-coupled receptor signaling proteins Gq and beta-arrestin-1 are essential for fluid reabsorption because they mediate coupling between an orphan receptor ADGRG2 (GPR64) and the ion channel CFTR. | Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D, Yu X, Sun JP., Free PMC Article | 08/10/2019 |
| These findings collectively support the concept that Gq-protein-coupled receptor activation functions as a molecular switch to favor capillary TRPV4 activity over Kir2.1 signaling, an observation with potentially profound significance for the control of cerebral blood flow. | PIP(2) depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells.
Harraz OF, Longden TA, Hill-Eubanks D, Nelson MT., Free PMC Article | 02/9/2019 |
| Repeated treatment with methamphetamine (METH)increased behavioral sensitization as well as Galphaq/11 protein expression and Galpha protein activity in the striata of mice, while a single treatment of METH at the same dose did not affect these parameters. Repeated intrastriatal injections of a Galphaq/11 inhibitor reduced behavioral sensitization and striatal dopamine level in response to METH. | The role of striatal Gα(q/11) protein in methamphetamine-induced behavioral sensitization in mice.
Lee KW, Kim K, Kim HC, Lee SY, Jang CG. | 09/15/2018 |
| these data highlighted the critical role of Galphaq in regulating Th17 differentiation and multiple sclerosis pathogenesis | Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation.
Lai W, Cai Y, Zhou J, Chen S, Qin C, Yang C, Liu J, Xie X, Du C., Free PMC Article | 03/10/2018 |
| in colonic crypt cultures, the GLP-1 secretion induced by such Gq + Gs GPR40 agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these. | Gq and Gs signaling acting in synergy to control GLP-1 secretion.
Hauge M, Ekberg JP, Engelstoft MS, Timshel P, Madsen AN, Schwartz TW. | 02/24/2018 |
| results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury. | Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema.
John AE, Wilson MR, Habgood A, Porte J, Tatler AL, Stavrou A, Miele G, Jolly L, Knox AJ, Takata M, Offermanns S, Jenkins RG. | 11/26/2017 |
| the impaired working memory in forebrain-specific Perk knockout mice may stem from altered Gq protein-coupled intracellular Ca(2+) dynamics in cortical pyramidal neurons. | PERK regulates G(q) protein-coupled intracellular Ca(2+) dynamics in primary cortical neurons.
Zhu S, McGrath BC, Bai Y, Tang X, Cavener DR., Free PMC Article | 11/11/2017 |
| Emergence of a malignant phenotype may therefore arise from both under- and overexpression of Galpha11/q signaling, implicating its upstream regulation as a potential therapeutic target in a host of pathologic conditions | Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.
Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind JS., Free PMC Article | 09/9/2017 |
| Galphaq regulates the development of rheumatoid arthritis by modulating Th1 differentiation | Gαq Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation.
Wang D, Liu Y, Li Y, He Y, Zhang J, Shi G., Free PMC Article | 08/19/2017 |
| Fluid shear stress acts on the Galphaq-ERK5 signaling pathway to upregulate Cyclin B1 and CDK1 expression, thereby resulting in MC3T3-E1 cell proliferation. | Fluid shear stress promotes osteoblast proliferation via the Gαq-ERK5 signaling pathway.
Bo Z, Bin G, Jing W, Cuifang W, Liping A, Jinglin M, Jin J, Xiaoyi T, Cong C, Ning D, Yayi X. | 08/12/2017 |
| activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH neurons by suppressing the M-current and potentiating glutamatergic neurotransmission | Gq Protein-Coupled Membrane-Initiated Estrogen Signaling Rapidly Excites Corticotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus in Female Mice.
Hu P, Liu J, Yasrebi A, Gotthardt JD, Bello NT, Pang ZP, Roepke TA., Free PMC Article | 07/1/2017 |