| The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis. | The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis.
Mercado-Gómez M, Goikoetxea-Usandizaga N, Kerbert AJC, Gracianteparaluceta LU, Serrano-Maciá M, Lachiondo-Ortega S, Rodriguez-Agudo R, Gil-Pitarch C, Simón J, González-Recio I, Fondevila MF, Santamarina-Ojeda P, Fraga MF, Nogueiras R, Heras JL, Jalan R, Martínez-Chantar ML, Delgado TC. | 09/19/2024 |
| Pharmacological Inhibition of Glutaminase 1 Normalized the Metabolic State and CD4+ T Cell Response in Sjogren's Syndrome. | Pharmacological Inhibition of Glutaminase 1 Normalized the Metabolic State and CD4+ T Cell Response in Sjogren's Syndrome.
Fu J, Pu Y, Wang B, Li H, Yang X, Xie L, Shi H, Wang Z, Yin J, Zhan T, Shao Y, Chen C, Luo Q, Xu J, Zong Z, Wei X, Xiao W, Yu C, Zheng L., Free PMC Article | 04/2/2022 |
| Microglial glutaminase 1 deficiency mitigates neuroinflammation associated depression. | Microglial glutaminase 1 deficiency mitigates neuroinflammation associated depression.
Ji C, Tang Y, Zhang Y, Li C, Liang H, Ding L, Xia X, Xiong L, Qi XR, Zheng JC. | 03/19/2022 |
| Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly. | Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly.
Simon J, Nuñez-García M, Fernández-Tussy P, Barbier-Torres L, Fernández-Ramos D, Gómez-Santos B, Buqué X, Lopitz-Otsoa F, Goikoetxea-Usandizaga N, Serrano-Macia M, Rodriguez-Agudo R, Bizkarguenaga M, Zubiete-Franco I, Gutiérrez-de Juan V, Cabrera D, Alonso C, Iruzubieta P, Romero-Gomez M, van Liempd S, Castro A, Nogueiras R, Varela-Rey M, Falcón-Pérez JM, Villa E, Crespo J, Lu SC, Mato JM, Aspichueta P, Delgado TC, Martínez-Chantar ML., Free PMC Article | 07/3/2021 |
| SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells. | SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R, Lu Z. | 06/26/2021 |
| Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition. | Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition.
Hamada S, Matsumoto R, Tanaka Y, Taguchi K, Yamamoto M, Masamune A., Free PMC Article | 04/24/2021 |
| The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled. | The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled.
Li Y, Ramachandran S, Nguyen TT, Stalnecker CA, Cerione RA, Erickson JW., Free PMC Article | 09/19/2020 |
| STAT1 upregulates glutaminase and modulates amino acids and glutathione metabolism. | STAT1 upregulates glutaminase and modulates amino acids and glutathione metabolism.
Kondo S, Kato Y, Minagawa S, Sugimoto Y. | 09/12/2020 |
| Spontaneous colitis in IL-10-deficient mice was ameliorated via inhibiting glutaminase1. | Spontaneous colitis in IL-10-deficient mice was ameliorated via inhibiting glutaminase1.
Li J, Zuo L, Tian Y, He Y, Zhang Z, Guo P, Ge Y, Hu J., Free PMC Article | 08/29/2020 |
| Using the conditional-knockout mice, we demonstrated that both in vitro Th17 differentiation (P < 0.05) and the development of experimental autoimmune encephalitis were dependent on Gls1. | Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis.
Kono M, Yoshida N, Maeda K, Suárez-Fueyo A, Kyttaris VC, Tsokos GC., Free PMC Article | 02/22/2020 |
| results show that GLS1 mutant mice display moderate impairments of hippocampal glutamatergic neurotransmission and moderate changes in adaptive behaviors that have been shown to participate to the development of depressive-like state. | GLS1 Mutant Mice Display Moderate Alterations of Hippocampal Glutamatergic Neurotransmission Associated with Specific Adaptive Behavioral Changes.
Dutar P, Tolle V, Kervern M, Carcenac C, Carola V, Gross C, Savasta M, Darmon M, Masson J. | 04/6/2019 |
| Findings provide the first evidence that glutaminase C overexpression in the brain has deleterious effects on learning and synaptic integrity in vivo. | Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice.
Wang Y, Li Y, Zhao R, Wu B, Lanoha B, Tong Z, Peer J, Liu J, Xiong H, Huang Y, Zheng J., Free PMC Article | 06/9/2018 |
| Our results suggested that glutamine metabolism is involved in the pathogenesis of rheumatoid arthritis and that GLS1 plays an important role in regulating rheumatoid arthritis fibroblast-like synoviocyte proliferation | Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis.
Takahashi S, Saegusa J, Sendo S, Okano T, Akashi K, Irino Y, Morinobu A., Free PMC Article | 11/11/2017 |
| studies show that the formation of large GAC oligomers is not a pre-requisite for full enzymatic activity. They also offer a mechanism by which the binding of activators like inorganic phosphate enables the activation loop to communicate with the active site to ensure maximal rates of catalysis, and promotes the opening of the lid to achieve optimal product release. | Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS.
Li Y, Erickson JW, Stalnecker CA, Katt WP, Huang Q, Cerione RA, Ramachandran S., Free PMC Article | 05/20/2017 |
| Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators. | Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.
Stalnecker CA, Erickson JW, Cerione RA., Free PMC Article | 04/29/2017 |
| findings suggest that glutaminase Heterozygote mice have a pro-cognitive profile in the trace fear conditioning paradigm, and this phenotype involves activation of both hippocampus and Anterior Cingulate Cortex. | Glutaminase1 heterozygous mice show enhanced trace fear conditioning and Arc/Arg3.1 expression in hippocampus and cingulate cortex.
Hazan L, Gaisler-Salomon I. | 10/10/2015 |
| studies demonstrate that GLS is required for tumorigenesis and support small molecule and genetic inhibition of GLS as potential approaches for targeting the tumor cell-autonomous dependence on GLS for cancer therapy. | Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
Xiang Y, Stine ZE, Xia J, Lu Y, O'Connor RS, Altman BJ, Hsieh AL, Gouw AM, Thomas AG, Gao P, Sun L, Song L, Yan B, Slusher BS, Zhuo J, Ooi LL, Lee CG, Mancuso A, McCallion AS, Le A, Milone MC, Rayport S, Felsher DW, Dang CV., Free PMC Article | 08/15/2015 |
| The Phosphate-Activated Glutaminase(PAG) is mainly active in mouse kidney, brain and liver, and shows different kinetics depending on which type of PAG is expressed. | Determination of phosphate-activated glutaminase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).
Botman D, Tigchelaar W, Van Noorden CJ., Free PMC Article | 12/27/2014 |
| The network identified in glutaminase deficient fetal mouse brain involves (a) cellular assembly and organization and (b) cell signaling and cell cycle, suggesting that Gls is crucial for neuronal maturation. | Network of brain protein level changes in glutaminase deficient fetal mice.
Bae N, Wang Y, Li L, Rayport S, Lubec G., Free PMC Article | 08/31/2013 |
| kidney-type glutaminase (KGA) as a novel partner of Bmcc1s | Bmcc1s interacts with the phosphate-activated glutaminase in the brain.
Boulay AC, Burbassi S, Lorenzo HK, Loew D, Ezan P, Giaume C, Cohen-Salmon M. | 08/31/2013 |
| The up-regulation of neuronal glutaminase was demonstrated in situ in a murine model of HIV-1 encephalitis. | IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase.
Ye L, Huang Y, Zhao L, Li Y, Sun L, Zhou Y, Qian G, Zheng JC., Free PMC Article | 08/10/2013 |
| identified a novel distant regulatory element located approximately 120kb downstream of the gls promoter, and examined its regulatory relevance to gls gene expression in C2C12 cells | A conserved regulatory element located far downstream of the gls locus modulates gls expression through chromatin loop formation during myogenesis.
Yuasa K, Takeda S, Hijikata T. | 12/8/2012 |
| In wild-type (WT) mice, GLS1 gene expression was highest in the hippocampus and cortex, where it was reduced by about 50% in Glutaminase-deficient mice. | Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation.
Gaisler-Salomon I, Wang Y, Chuhma N, Zhang H, Golumbic YN, Mihali A, Arancio O, Sibille E, Rayport S., Free PMC Article | 08/18/2012 |
| GLS1 heterozygous (GLS1 het) mice showed about a 50% global reduction in glutaminase activity and showed hippocampal hypometabolism mainly in the CA1 subregion and subiculum. | Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia.
Gaisler-Salomon I, Miller GM, Chuhma N, Lee S, Zhang H, Ghoddoussi F, Lewandowski N, Fairhurst S, Wang Y, Conjard-Duplany A, Masson J, Balsam P, Hen R, Arancio O, Galloway MP, Moore HM, Small SA, Rayport S., Free PMC Article | 01/21/2010 |
| These results show that necrotic neurons activate in microglia a MyD88-dependent pathway responsible for a pro-inflammatory response that also leads to increased neurotoxic activity through induction of glutaminase. | Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway.
Pais TF, Figueiredo C, Peixoto R, Braz MH, Chatterjee S., Free PMC Article | 01/21/2010 |