| Chondroitin Sulfate Proteoglycan 4 Provides New Treatment Approach to Preventing Peritoneal Dissemination in Ovarian Cancer. | Chondroitin Sulfate Proteoglycan 4 Provides New Treatment Approach to Preventing Peritoneal Dissemination in Ovarian Cancer.
Uno K, Koya Y, Yoshihara M, Iyoshi S, Kitami K, Sugiyama M, Miyamoto E, Mogi K, Fujimoto H, Yamakita Y, Wang X, Nawa A, Kajiyama H., Free PMC Article | 02/22/2024 |
| Disrupting mechanical homeostasis promotes matrix metalloproteinase-13 mediated processing of neuron glial antigen 2 in mandibular condylar cartilage. | Disrupting mechanical homeostasis promotes matrix metalloproteinase-13 mediated processing of neuron glial antigen 2 in mandibular condylar cartilage.
Bagheri Varzaneh M, Zhao Y, Rozynek J, Han M, Reed DA., Free PMC Article | 05/12/2023 |
| Discovery of Hippo signaling as a regulator of CSPG4 expression and as a therapeutic target for Clostridioides difficile disease. | Discovery of Hippo signaling as a regulator of CSPG4 expression and as a therapeutic target for Clostridioides difficile disease.
Larabee JL, Doyle DA, Ahmed UKB, Shadid TM, Sharp RR, Jones KL, Kim YM, Li S, Ballard JD., Free PMC Article | 04/12/2023 |
| Trophoblast-specific knockdown of CSPG4 expression causes pregnancy complications with poor placentation in mice. | Trophoblast-specific knockdown of CSPG4 expression causes pregnancy complications with poor placentation in mice.
Xu J, Yuan A, Su R, Yang Q, Fan X, Zhang J. | 02/28/2023 |
| Neuron-Glial Antigen 2 Participates in Liver Fibrosis via Regulating the Differentiation of Bone Marrow Mesenchymal Stem Cell to Myofibroblast. | Neuron-Glial Antigen 2 Participates in Liver Fibrosis via Regulating the Differentiation of Bone Marrow Mesenchymal Stem Cell to Myofibroblast.
Yang L, Zhang H, Dong C, Yue W, Xue R, Liu F, Yang L, Li L., Free PMC Article | 01/28/2023 |
| CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response. | CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response.
Boudin L, de Nonneville A, Finetti P, Mescam L, Le Cesne A, Italiano A, Blay JY, Birnbaum D, Mamessier E, Bertucci F., Free PMC Article | 10/15/2022 |
| CSPG4 Is a Potential Therapeutic Target in Anaplastic Thyroid Cancer. | CSPG4 Is a Potential Therapeutic Target in Anaplastic Thyroid Cancer.
Egan CE, Stefanova D, Ahmed A, Raja VJ, Thiesmeyer JW, Chen KJ, Greenberg JA, Zhang T, He B, Finnerty BM, Zarnegar R, Jin MM, Scognamiglio T, Dephoure N, Fahey T 3rd, Min IM., Free PMC Article | 03/26/2022 |
| Identification of a germline CSPG4 variation in a family with neurofibromatosis type 1-like phenotype. | Identification of a germline CSPG4 variation in a family with neurofibromatosis type 1-like phenotype.
Bai Z, Qu Y, Shi L, Li X, Yang Z, Ji M, Hou P., Free PMC Article | 03/19/2022 |
| NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by myocardin-related transcription factors in smooth muscle cells. | NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by myocardin-related transcription factors in smooth muscle cells.
Rippe C, Morén B, Liu L, Stenkula KG, Mustaniemi J, Wennström M, Swärd K., Free PMC Article | 12/18/2021 |
| Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF. | Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF.
Uranowska K, Kalic T, Valtsanidis V, Kitzwögerer M, Breiteneder H, Hafner C., Free PMC Article | 10/30/2021 |
| Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive. | Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive.
Henkel D, Tatge H, Schöttelndreier D, Tao L, Dong M, Gerhard R., Free PMC Article | 07/24/2021 |
| High NG2 expression is associated with glioblastoma. | A non-hierarchical organization of tumorigenic NG2 cells in glioblastoma promoted by EGFR.
Al-Mayhani TF, Heywood RM, Vemireddy V, Lathia JD, Piccirillo SGM, Watts C., Free PMC Article | 07/4/2020 |
| We observed familial segregation of two rare missense mutations in Chondroitin Sulfate Proteoglycan 4 (CSPG4) (c.391G > A [p.A131T], MAF 7.79 x 10(-5) and c.2702T > G [p.V901G], MAF 2.51 x 10(-3)). The CSPG4(A131T) mutation was absent from the Swedish Schizophrenia Exome Sequencing Study (2536 cases, 2543 controls), while the CSPG4(V901G) mutation was nominally enriched in cases (11 cases vs. 3 controls) | Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.
de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PMJ, Hoencamp E, Bergink V, GROUP Study Consortium, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD, Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA., Free PMC Article | 03/7/2020 |
| Ng2/Cspg4 deletion altered the expression of genes regulating cell proliferation and apoptosis. | Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.
Hsu SC, Nadesan P, Puviindran V, Stallcup WB, Kirsch DG, Alman BA., Free PMC Article | 02/9/2019 |
| Study suggests that CSPG4 and progranulin may engage in mutual cell-to-cell communications orchestrating regenerative processes, which may enhance the repair capacity of the adult brain. CSPG4 might engage with PTPRs as cell bound ligand or as soluble molecule after its shedding, possibly regulating thereby adhesion and synaptic strength, which contribute to the rebuilding of connectivity after injury. [review] | NG2/CSPG4 and progranulin in the posttraumatic glial scar.
Schäfer MKE, Tegeder I. | 02/2/2019 |
| NG2/CSPG4 expression has been demonstrated in oligodendrogliomas, astrocytomas, and glioblastomas (GB), and it correlates with malignancy | The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas.
Schiffer D, Mellai M, Boldorini R, Bisogno I, Grifoni S, Corona C, Bertero L, Cassoni P, Casalone C, Annovazzi L., Free PMC Article | 01/5/2019 |
| DNA methylation status of blood leukocytes may be associated with susceptibility to Colorectal Cancer . The MCSM-H of blood leukocytes may be associated with CRC risk, especially in younger people. | Methylation Status of Transcriptional Modulatory Genes Associated with Colorectal Cancer in Northeast China.
Gao HL, Wang X, Sun HR, Zhou JD, Lin SQ, Xing YH, Zhu L, Zhou HB, Zhao YS, Chi Q, Liu YP., Free PMC Article | 09/29/2018 |
| This study revealed that CSPG4 interacted with perlecan to support cell adhesion and actin polymerization and the data suggest a novel mechanism by which CSPG4 expressing cells might attach to perlecan-rich matrices so as those found in connective tissues and basement membranes. | Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.
Tang F, Lord MS, Stallcup WB, Whitelock JM., Free PMC Article | 05/19/2018 |
| Both tumor cell and vascular NG2 expression were shown to be present in a significant number of patients with colorectal cancer and this makes NG2 a double target for anti-tumor therapies. | Nerve/Glial Antigen 2: A Novel Target for Anti-Tumor Therapy in Colorectal Cancer.
Cengiz C, Bulut S, Boyacioglu AS, Kuzu MA. | 05/5/2018 |
| NG2 may represent a promising target for the modulation of ICAM-1-mediated immune responses. | Nerve/glial antigen (NG) 2 is a crucial regulator of intercellular adhesion molecule (ICAM)-1 expression.
Schmitt BM, Laschke MW, Rössler OG, Huang W, Scheller A, Menger MD, Ampofo E. | 04/7/2018 |
| In addition to establishing the binding region for CSPG4, this work ascribes for the first time a role in TcdB CROPs in receptor binding and further clarifies the relative roles of host receptors in TcdB pathogenesis. | Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.
Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA., Free PMC Article | 10/28/2017 |
| of NG2/CSPG4 rather than changes in CD44 or Ki-67 expression is associated with low overall survival in glioblastoma multiforme patients | Prognostic relevance of NG2/CSPG4, CD44 and Ki-67 in patients with glioblastoma.
Tsidulko AY, Kazanskaya GM, Kostromskaya DV, Aidagulova SV, Kiselev RS, Volkov AM, Kobozev VV, Gaitan AS, Krivoshapkin AL, Grigorieva EV. | 10/21/2017 |
| The results indicate that CSPG4/NG2 has roles in regulating chondrosarcoma cell function in relation to growth, spread and resistance to chemotherapy. | Functional roles of CSPG4/NG2 in chondrosarcoma.
Jamil NS, Azfer A, Worrell H, Salter DM., Free PMC Article | 07/22/2017 |
| A positive CSPG4 stain may be associated with an increased risk of metastasis and mortality from chordoma. | CSPG4 as a prognostic biomarker in chordoma.
Schoenfeld AJ, Wang X, Wang Y, Hornicek FJ, Nielsen GP, Duan Z, Ferrone S, Schwab JH., Free PMC Article | 07/1/2017 |
| CSPG4 is a cell surface proteoglycan regulated by interleukin 11 in human endometrial epithelial cancer cells. the data suggest that CSPG4 inhibition may impair endometrial cancer progression by reducing cancer cell proliferation, migration and potentially epithelial-to-mesenchymal transition. | Chondroitin sulfate proteoglycan protein is stimulated by interleukin 11 and promotes endometrial epithelial cancer cell proliferation and migration.
Winship A, Van Sinderen M, Heffernan-Marks A, Dimitriadis E. | 06/24/2017 |