| Neurocan genome-wide psychiatric risk variant affects explicit memory performance and hippocampal function in healthy humans. | Neurocan genome-wide psychiatric risk variant affects explicit memory performance and hippocampal function in healthy humans.
Assmann A, Richter A, Schütze H, Soch J, Barman A, Behnisch G, Knopf L, Raschick M, Schult A, Wüstenberg T, Behr J, Düzel E, Seidenbecher CI, Schott BH. | 08/21/2021 |
| NCAN rs2228603 is not a risk factor for the incidence of NAFLD in Chinese population. The dual and opposite role of T variant in protecting liver with a higher level of HDL was found. | Role of NCAN rs2228603 polymorphism in the incidence of nonalcoholic fatty liver disease: a case-control study.
Wu MJ, Yuan C, Lu LL, An BQ, Xuan SY, Xin YN., Free PMC Article | 05/6/2017 |
| This study aims to analyze the influences of single-nucleotide polymorphism in the NCAN-CILP2 region on non-alcoholic fatty liver disease and plasma lipid levels in the Asian and Pacific ethnic groups. | Replication analysis of genetic association of the NCAN-CILP2 region with plasma lipid levels and non-alcoholic fatty liver disease in Asian and Pacific ethnic groups.
Boonvisut S, Nakayama K, Makishima S, Watanabe K, Miyashita H, Lkhagvasuren M, Kagawa Y, Iwamoto S., Free PMC Article | 10/22/2016 |
| NCAN genotype is associated with limbic gray matter alterations in healthy and subjects with major depression in brain areas implicated in emotion perception and regulation | NCAN Cross-Disorder Risk Variant Is Associated With Limbic Gray Matter Deficits in Healthy Subjects and Major Depression.
Dannlowski U, Kugel H, Grotegerd D, Redlich R, Suchy J, Opel N, Suslow T, Konrad C, Ohrmann P, Bauer J, Kircher T, Krug A, Jansen A, Baune BT, Heindel W, Domschke K, Forstner AJ, Nöthen MM, Treutlein J, Arolt V, Hohoff C, Rietschel M, Witt SH., Free PMC Article | 06/28/2016 |
| current data demonstrate that common genetic variation in NCAN influences both neural processing and cognitive performance in healthy subjects. | A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects.
Raum H, Dietsche B, Nagels A, Witt SH, Rietschel M, Kircher T, Krug A., Free PMC Article | 08/22/2015 |
| The frequency of the NCAN rs2228603 T allele was significantly increased in patients with HCC due to ALD (15.1%) compared to alcoholic cirrhosis without HCC (9.3%), alcoholic controls (7.2%), healthy controls (7.9%), and HCV associated HCC (9.1%). | A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease.
Nischalke HD, Lutz P, Krämer B, Söhne J, Müller T, Rosendahl J, Fischer J, Berg T, Hittatiya K, Fischer HP, Soyka M, Semmo N, Nattermann J, Sauerbruch T, Strassburg CP, Stickel F, Spengler U. | 06/27/2015 |
| NCAN risk variant is associated with cortical folding and thickness in bipolar disorder and schizophrenia. | Common variation in NCAN, a risk factor for bipolar disorder and schizophrenia, influences local cortical folding in schizophrenia.
Schultz CC, Mühleisen TW, Nenadic I, Koch K, Wagner G, Schachtzabel C, Siedek F, Nöthen MM, Rietschel M, Deufel T, Kiehntopf M, Cichon S, Reichenbach JR, Sauer H, Schlösser RG. | 10/25/2014 |
| Conditional analysis shows that a neighbouring gene, TM6SF2, not NCAN, is responsible for the Chr 19 GWAS locus previously associated with fibrosing non-alcoholic fatty liver disease (NAFLD). | TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease.
Liu YL, Reeves HL, Burt AD, Tiniakos D, McPherson S, Leathart JB, Allison ME, Alexander GJ, Piguet AC, Anty R, Donaldson P, Aithal GP, Francque S, Van Gaal L, Clement K, Ratziu V, Dufour JF, Day CP, Daly AK, Anstee QM., Free PMC Article | 09/3/2014 |
| NCAN rs2228603[T] is a risk factor for liver inflammation and fibrosis, suggesting that this locus is responsible for progression from steatosis to steatohepatitis. | Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity.
Gorden A, Yang R, Yerges-Armstrong LM, Ryan KA, Speliotes E, Borecki IB, Harris TB, Chu X, Wood GC, Still CD, Shuldiner AR, Gerhard GS, GOLD Consortium., Free PMC Article | 12/21/2013 |
| no genetic association between risk allele A for NCAN locus rs1064395 and schizophrenia. | Assessment of relatedness between neurocan gene as bipolar disorder susceptibility locus and schizophrenia.
Oruč L, Kapur-Pojskić L, Ramić J, Pojskić N, Bajrović K., Free PMC Article | 09/21/2013 |
| In the combined patient sample, the NCAN risk allele was significantly associated with the "mania" factor, in particular the subdimension "overactivity. | Studies in humans and mice implicate neurocan in the etiology of mania.
Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram Ö, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A. | 11/17/2012 |
| The rs1064395 A-allele was significantly over-represented in schizophrenia patients compared to controls. Our data suggest that genetic variation in NCAN is a common risk factor for bipolar disorder and schizophrenia. | Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.
Mühleisen TW, Mattheisen M, Strohmaier J, Degenhardt F, Priebe L, Schultz CC, Breuer R, Meier S, Hoffmann P, GROUP Investigators, Rivandeneira F, Hofman A, Uitterlinden AG, Moebus S, Gieger C, Emeny R, Ladwig KH, Wichmann HE, Schwarz M, Kammerer-Ciernioch J, Schlösser RG, Nenadic I, Sauer H, Mössner R, Maier W, Rujescu D, Lange C, Ophoff RA, Schulze TG, Rietschel M, Nöthen MM, Cichon S. | 10/20/2012 |
| High neurocan is associated with the invasive phenotype of low-grade astrocytoma. | Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma.
Varga I, Hutóczki G, Szemcsák CD, Zahuczky G, Tóth J, Adamecz Z, Kenyeres A, Bognár L, Hanzély Z, Klekner A. | 08/4/2012 |
| Sex (male)-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels is observed both the Mulao and Han ethnic groups. | Sex-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels in the Mulao and Han populations.
Yan TT, Yin RX, Li Q, Huang P, Zeng XN, Huang KK, Aung LH, Wu DF, Liu CW, Pan SL., Free PMC Article | 05/26/2012 |
| Genetic variation in the neurocan gene (NCAN) showed genome-wide significant association with bipolar disorder. | Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder.
Cichon S, Mühleisen TW, Degenhardt FA, Mattheisen M, Miró X, Strohmaier J, Steffens M, Meesters C, Herms S, Weingarten M, Priebe L, Haenisch B, Alexander M, Vollmer J, Breuer R, Schmäl C, Tessmann P, Moebus S, Wichmann HE, Schreiber S, Müller-Myhsok B, Lucae S, Jamain S, Leboyer M, Bellivier F, Etain B, Henry C, Kahn JP, Heath S, Bipolar Disorder Genome Study (BiGS) Consortium, Hamshere M, O'Donovan MC, Owen MJ, Craddock N, Schwarz M, Vedder H, Kammerer-Ciernioch J, Reif A, Sasse J, Bauer M, Hautzinger M, Wright A, Mitchell PB, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Gustafsson O, Andreassen O, Djurovic S, Sigurdsson E, Steinberg S, Stefansson H, Stefansson K, Kapur-Pojskic L, Oruc L, Rivas F, Mayoral F, Chuchalin A, Babadjanova G, Tiganov AS, Pantelejeva G, Abramova LI, Grigoroiu-Serbanescu M, Diaconu CC, Czerski PM, Hauser J, Zimmer A, Lathrop M, Schulze TG, Wienker TF, Schumacher J, Maier W, Propping P, Rietschel M, Nöthen MM., Free PMC Article | 05/21/2011 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.
Kähler AK, Djurovic S, Rimol LM, Brown AA, Athanasiu L, Jönsson EG, Hansen T, Gústafsson O, Hall H, Giegling I, Muglia P, Cichon S, Rietschel M, Pietiläinen OP, Peltonen L, Bramon E, Collier D, St Clair D, Sigurdsson E, Petursson H, Rujescu D, Melle I, Werge T, Steen VM, Dale AM, Matthews RT, Agartz I, Andreassen OA. | 12/5/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesPharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.
Hu M, Lui SS, Mak VW, Chu TT, Lee VW, Poon EW, Tsui TK, Ko GT, Baum L, Tam LS, Li EK, Tomlinson B. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.
Deo RC, Reich D, Tandon A, Akylbekova E, Patterson N, Waliszewska A, Kathiresan S, Sarpong D, Taylor HA Jr, Wilson JG. | 02/11/2009 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton P, Hercberg S, Zelenika D, Chen WM, Li Y, Scott LJ, Scheet PA, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL, Abecasis GR., Free PMC Article | 03/13/2008 |