| Decreased connexin 40 expression of the sinoatrial node mediates ischemic stroke-induced arrhythmia in mice. | Decreased connexin 40 expression of the sinoatrial node mediates ischemic stroke-induced arrhythmia in mice.
Yao ZJ, Jiang YP, Yuan D, Hong P, He MJ, Li FX, Xu SY, Lin HB, Zhang HF. | 05/29/2024 |
| Capillary oxygen regulates demand-supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis. | Capillary oxygen regulates demand-supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis.
Kowalewska PM, Milkovich SL, Goldman D, Sandow SL, Ellis CG, Welsh DG., Free PMC Article | 02/20/2024 |
| Connexin Lateralization Contributes to Male Susceptibility to Atrial Fibrillation. | Connexin Lateralization Contributes to Male Susceptibility to Atrial Fibrillation.
Thibault S, Ton AT, Huynh F, Fiset C., Free PMC Article | 10/15/2022 |
| Calcium Signal Profiles in Vascular Endothelium from Cdh5-GCaMP8 and Cx40-GCaMP2 Mice. | Calcium Signal Profiles in Vascular Endothelium from Cdh5-GCaMP8 and Cx40-GCaMP2 Mice.
Chen YL, Baker TM, Lee F, Shui B, Lee JC, Tvrdik P, Kotlikoff MI, Sonkusare SK., Free PMC Article | 12/25/2021 |
| Systemic therapy in an RNA toxicity mouse model with an antisense oligonucleotide therapy targeting a non-CUG sequence within the DMPK 3'UTR RNA. | Systemic therapy in an RNA toxicity mouse model with an antisense oligonucleotide therapy targeting a non-CUG sequence within the DMPK 3'UTR RNA.
Yadava RS, Yu Q, Mandal M, Rigo F, Bennett CF, Mahadevan MS., Free PMC Article | 08/14/2021 |
| Characteristics of Ventricular Electrophysiological Substrates in Metabolic Mice Treated with Empagliflozin. | Characteristics of Ventricular Electrophysiological Substrates in Metabolic Mice Treated with Empagliflozin.
Jhuo SJ, Liu IH, Tasi WC, Chou TW, Lin YH, Wu BN, Lee KT, Lai WT., Free PMC Article | 07/17/2021 |
| Conjugated activation of myocardial-specific transcription of Gja5 by a pair of Nkx2-5-Shox2 co-responsive elements. | Conjugated activation of myocardial-specific transcription of Gja5 by a pair of Nkx2-5-Shox2 co-responsive elements.
Yang T, Huang Z, Li H, Wang L, Chen Y., Free PMC Article | 02/6/2021 |
| Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor gamma co-activator deficient hearts modelling mitochondrial dysfunction. | Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction.
Edling CE, Fazmin IT, Saadeh K, Chadda KR, Ahmad S, Valli H, Huang CL, Jeevaratnam K., Free PMC Article | 10/24/2020 |
| Thus, while gestation and gross development were conserved in Cx40(-/-)Panx1(-/-) mice, they exhibit cardiac hypertrophy, hypertension, and impaired endothelial-mediated vasodilation that phenocopies Cx40(-/-) mice. | Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice.
Novielli-Kuntz NM, Jelen M, Barr K, DeLalio LJ, Feng Q, Isakson BE, Gros R, Laird DW., Free PMC Article | 02/1/2020 |
| findings reveal a role of Cx40 in regulation of ROCK1 and MLC20 that contributes critically to lung vascular barrier failure in acute lung injury. | Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway.
Yin J, Lv L, Zhai P, Long T, Zhou Q, Pan H, Botwe G, Wang L, Wang Q, Tan L, Kuebler WM. | 11/16/2019 |
| Deletion of Cx40 decreases the calcium sensitivity of renin-secreting juxtaglomerular cells. | Lack of connexin 40 decreases the calcium sensitivity of renin-secreting juxtaglomerular cells.
Steppan D, Geis L, Pan L, Gross K, Wagner C, Kurtz A., Free PMC Article | 08/31/2019 |
| High CX40 expression is associated with neoplasms. | Targeting endothelial connexin40 inhibits tumor growth by reducing angiogenesis and improving vessel perfusion.
Alonso F, Domingos-Pereira S, Le Gal L, Derré L, Meda P, Jichlinski P, Nardelli-Haefliger D, Haefliger JA., Free PMC Article | 12/16/2017 |
| Endothelial Cx40 contributes to the early stages of physiological angiogenesis in the developing retina, by regulating vessel growth and maturation. | Targeting Cx40 (Connexin40) Expression or Function Reduces Angiogenesis in the Developing Mouse Retina.
Haefliger JA, Allagnat F, Hamard L, Le Gal L, Meda P, Nardelli-Haefliger D, Génot E, Alonso F. | 11/11/2017 |
| Cx40 may participate in compromised endothelial electrical couplilng response in the microvasculature during sepsis. | Critical Role of Cx40 in Reduced Endothelial Electrical Coupling by Lipopolysaccharide and Hypoxia-Reoxygenation.
Siddiqui M, Swarbreck S, Shao Q, Secor D, Peng T, Laird DW, Tyml K. | 09/9/2017 |
| We also detected a significant decrease in the concentration of mitochondrial reactive oxygen species (ROS) in Cx40 KO MCECs. Cx40 overexpression in ECs significantly increased resting [Ca(2+)]mito level and calcium uptake by mitochondria in response to increased [Ca(2+)]cyto and augmented mitochondrial ROS production. These data suggest that mitochondrial Cx40 contributes to the regulation of mitochondrial calcium homeos | Mitochondrial connexin40 regulates mitochondrial calcium uptake in coronary endothelial cells.
Guo R, Si R, Scott BT, Makino A., Free PMC Article | 06/10/2017 |
| intermittent hypoxia (but not sleep fragmentation) causes reductions and remodeling of atrial Cx40 and Cx43. | Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins.
Gemel J, Su Z, Gileles-Hillel A, Khalyfa A, Gozal D, Beyer EC., Free PMC Article | 06/10/2017 |
| High-fat diet increases vulnerability to atrial arrhythmia by down-regulation of Cx40 via miR-27b. | High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via miR-27b.
Takahashi K, Sasano T, Sugiyama K, Kurokawa J, Tamura N, Soejima Y, Sawabe M, Isobe M, Furukawa T. | 10/22/2016 |
| These data indicate a fine regulation of the gap junction channel make-up in function of the type and the ratio of co-expressed connexins that specifically regulates chemical and electrical coupling. | Relating specific connexin co-expression ratio to connexon composition and gap junction function.
Desplantez T, Grikscheit K, Thomas NM, Peters NS, Severs NJ, Dupont E. | 10/1/2016 |
| Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations. | Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations.
Gkatzis K, Thalgott J, Dos-Santos-Luis D, Martin S, Lamandé N, Carette MF, Disch F, Snijder RJ, Westermann CJ, Mager JJ, Oh SP, Miquerol L, Arthur HM, Mummery CL, Lebrin F. | 08/13/2016 |
| We conclude that endothelial expression of the chemically dysfunctional Cx40T202S reduces peripheral vasodilator capacity mediated by SKCa-dependent hyperpolarisation and also increases blood pressure. | Perturbation of chemical coupling by an endothelial Cx40 mutant attenuates endothelium-dependent vasodilation by KCa channels and elevates blood pressure in mice.
Chaston DJ, Haddock RE, Howitt L, Morton SK, Brown RD, Matthaei KI, Hill CE. | 05/21/2016 |
| Cx40 is a requirement for the pressure control of renin secretion irrespective of the localization of renin secreting cells. | Connexin 40 is dispensable for vascular renin cell recruitment but is indispensable for vascular baroreceptor control of renin secretion.
Machura K, Neubauer B, Müller H, Tauber P, Kurtz A, Kurtz L. | 04/16/2016 |
| Cx37 is more markedly involved in basal NO release, release of cyclooxygenase products and the regulation of the sensitivity for Acetylcholine as compared to Cx40. | Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release.
Meens MJ, Alonso F, Le Gal L, Kwak BR, Haefliger JA., Free PMC Article | 03/12/2016 |
| This study showed the progressive changes of Cx 40 at protein and mRNA levels in the mouse hippocampus during and after pilocarpine-induced status epilepticus. | Astrocytic Cx 43 and Cx 40 in the mouse hippocampus during and after pilocarpine-induced status epilepticus.
Wu XL, Tang YC, Lu QY, Xiao XL, Song TB, Tang FR. | 12/12/2015 |
| Cx40 and Cx37 play an in vivo role in the regulation of eNOS. | Interplay between connexin40 and nitric oxide signaling during hypertension.
Le Gal L, Alonso F, Mazzolai L, Meda P, Haefliger JA. | 05/16/2015 |
| Loss of functional endothelial connexin40 results in exercise-induced hypertension in mice. | Loss of functional endothelial connexin40 results in exercise-induced hypertension in mice.
Morton SK, Chaston DJ, Howitt L, Heisler J, Nicholson BJ, Fairweather S, Bröer S, Ashton AW, Matthaei KI, Hill CE. | 04/18/2015 |