| Functional Involvement of ADRA1D in Cutaneous Melanoma Progression and Angiogenesis. | Functional Involvement of ADRA1D in Cutaneous Melanoma Progression and Angiogenesis.
Wang J, Ning D, Xie D, Chen X, Cao X, Wan C. | 08/14/2023 |
| Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and alpha1-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays. | Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α(1)-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays.
Gao X, Enten GA, DeSantis AJ, Volkman BF, Gaponenko V, Majetschak M., Free PMC Article | 01/16/2021 |
| N-glycosylation of alpha1D-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis. | N-glycosylation of α(1D)-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis.
Janezic EM, Lauer SM, Williams RG, Chungyoun M, Lee KS, Navaluna E, Lau HT, Ong SE, Hague C., Free PMC Article | 11/28/2020 |
| The roles of adrenoceptor alpha 1D phosphorylation sites/clusters were investigated. Carboxyl terminus phosphorylation seems to control receptor's membrane localization. Intracellular loop 3 mutation caused agonist-induced sustained ERK1/2 activation. | Distinct phosphorylation sites/clusters in the carboxyl terminus regulate α(1D)-adrenergic receptor subcellular localization and signaling.
Carmona-Rosas G, Hernández-Espinosa DA, Alcántara-Hernández R, Alfonzo-Méndez MA, García-Sainz JA. | 02/29/2020 |
| ADRA1 expression was greater on vascular smooth muscle in burn scars than in unscarred tissue, and greater on dermal nerve fibres, blood vessels and fibroblasts in keloid scars than in either burn scars or unscarred skin. | Up-regulation of α(1)-adrenoceptors in burn and keloid scars.
Drummond PD, Dawson LF, Wood FM, Fear MW. | 03/16/2019 |
| Hetero-oligomerization of a1B/D-adrenergic receptor with the chemokine (C-X-C motif) receptor 4:atypical chemokine receptor 3 heteromeric complex is required for a1B/Dadrenergic receptor function. | α(1)-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells.
Albee LJ, Eby JM, Tripathi A, LaPorte HM, Gao X, Volkman BF, Gaponenko V, Majetschak M., Free PMC Article | 06/16/2018 |
| processing of the ADRA1D NT domain is a physiological mechanism employed by cells to generate a functional ADRA1D isoform with optimal pharmacodynamic properties. | Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics.
Kountz TS, Lee KS, Aggarwal-Howarth S, Curran E, Park JM, Harris DA, Stewart A, Hendrickson J, Camp ND, Wolf-Yadlin A, Wang EH, Scott JD, Hague C., Free PMC Article | 05/13/2017 |
| expression of carboxyl terminus-truncated alpha1D-adrenoceptors alters ERK and p38 phosphorylation state. | Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway.
Alfonzo-Méndez MA, Castillo-Badillo JA, Romero-Ávila MT, Rivera R, Chun J, García-Sáinz JA., Free PMC Article | 02/25/2017 |
| Immunoreactivity for ADRA2D was densely distributed in submucosal glands of nasal turbinates. | Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate.
Shirasaki H, Kanaizumi E, Himi T. | 01/14/2017 |
| In conclusion, our work clarified some cellular aspects promoted by alpha1D-AR activity modulation and supports a further pharmacological approach in the cure of hormone-refractory PC, by targeting specifically this AR subtype | A selective alpha1D-adrenoreceptor antagonist inhibits human prostate cancer cell proliferation and motility "in vitro".
Colciago A, Mornati O, Ferri N, Castelnovo LF, Fumagalli L, Bolchi C, Pallavicini M, Valoti E, Negri-Cesi P. | 12/17/2016 |
| This study showed that ADRA1D gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders. | The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients.
Liu J, Siyahhan Julnes P, Chen J, Ehrlich S, Walton E, Calhoun VD., Free PMC Article | 10/1/2016 |
| alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts. | The stimulatory effects of alpha1-adrenergic receptors on TGF-beta1, IGF-1 and hyaluronan production in human skin fibroblasts.
Liao MH, Liu SS, Peng IC, Tsai FJ, Huang HH. | 09/5/2015 |
| Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation. | Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.
Morelli MB, Amantini C, Nabissi M, Liberati S, Cardinali C, Farfariello V, Tomassoni D, Quaglia W, Piergentili A, Bonifazi A, Del Bello F, Santoni M, Mammana G, Servi L, Filosa A, Gismondi A, Santoni G., Free PMC Article | 07/25/2015 |
| Mean alpha-receptor stain rates in renal pelvis were 2.65 +/- 0.74, 1.35 +/- 0.81 and 2.9 +/- 0.30 for alpha 1A, 1B and 1D, respectively. For calyces, the rates are 2.40 +/- 0.82, 1.50 +/- 0.76 and 2.75 +/- 0.44 for alpha 1A, 1B and 1D, respectively. | The presence and distribution of alpha adrenergic receptors in human renal pelvis and calyces.
Karabacak OR, Yilmazer D, Ozturk U, Sener NC, Saltas H, Karabacak Y, Alper M. | 06/7/2014 |
| alpha(1)(D)-adrenoceptors in the lower urinary tract might play an important role in the pathophysiology of lower urinary tract disorders. [review] | Male lower urinary tract symptoms and α1D-adrenoceptors.
Ishizuka O, Imamura T, Kurizaki Y, Nishizawa O, Andersson KE. | 07/6/2013 |
| Data show that alpha-dystrobrevin-1 recruits alpha-catulin, which supersensitizes alpha(1D)-AR functional responses by recruiting effector molecules to the signalosome. | Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.
Lyssand JS, Whiting JL, Lee KS, Kastl R, Wacker JL, Bruchas MR, Miyatake M, Langeberg LK, Chavkin C, Scott JD, Gardner RG, Adams ME, Hague C., Free PMC Article | 05/14/2011 |
| Genetic characteristics associated with response to domperidone therapy included polymorphisms in the drug transporter gene ABCB1, the potassium channel KCNH2 gene, and alpha1D--adrenoceptor ADRA1D gene. | Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects.
Parkman HP, Jacobs MR, Mishra A, Hurdle JA, Sachdeva P, Gaughan JP, Krynetskiy E, Parkman HP, Jacobs MR, Mishra A, Hurdle JA, Sachdeva P, Gaughan JP, Krynetskiy E. | 01/22/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects.
Parkman HP, Jacobs MR, Mishra A, Hurdle JA, Sachdeva P, Gaughan JP, Krynetskiy E, Parkman HP, Jacobs MR, Mishra A, Hurdle JA, Sachdeva P, Gaughan JP, Krynetskiy E. | 12/5/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Our data indicate that carboxyl terminus-truncated alpha(1D)-adrenoceptors are fully functional and subjected to regulation by phosphorylation. The roles of the carboxyl termini differ among alpha(1)-adrenoceptor subtypes. | Signaling properties of human alpha(1D)-adrenoceptors lacking the carboxyl terminus: intrinsic activity, agonist-mediated activation, and desensitization.
Rodríguez-Pérez CE, Romero-Avila MT, Reyes-Cruz G, García-Sáinz JA. | 01/21/2010 |
| ADRA1D induces vascular smooth muscle apoptosis via a p53-dependent mechanism. | The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.
García-Cazarín ML, Smith JL, Clair DK, Piascik MT. | 01/21/2010 |
| expression in distal ureter higher than in proximal and mid ureter but not statistically significant | Localizations and expressions of alpha-1A, alpha-1B and alpha-1D adrenoceptors in human ureter.
Park HK, Choi EY, Jeong BC, Kim HH, Kim BK. | 01/21/2010 |
| ADRA1D polymorphisms are predictive markers of the response to beta-blockers | Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy.
Nonen S, Okamoto H, Fujio Y, Takemoto Y, Yoshiyama M, Hamaguchi T, Matsui Y, Yoshikawa J, Kitabatake A, Azuma J, Nonen S, Okamoto H, Fujio Y, Takemoto Y, Yoshiyama M, Hamaguchi T, Matsui Y, Yoshikawa J, Kitabatake A, Azuma J. | 01/21/2010 |
| Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy.
Nonen S, Okamoto H, Fujio Y, Takemoto Y, Yoshiyama M, Hamaguchi T, Matsui Y, Yoshikawa J, Kitabatake A, Azuma J, Nonen S, Okamoto H, Fujio Y, Takemoto Y, Yoshiyama M, Hamaguchi T, Matsui Y, Yoshikawa J, Kitabatake A, Azuma J. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis.
Sugaya K, Nishijima S, Yamada T, Miyazato M, Hatano T, Ogawa Y. | 03/13/2008 |