| GGsTop is a newly-discovered gamma-glutamyl transpeptidase (GGT) inhibitor...GGsTop treated Oral mucositis (OM) quickly and safely. GGsTop is highly valuable for use as a treatment for OM | Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis.
Shimamura Y, Takeuchi I, Terada H, Makino K. | 01/12/2019 |
| These findings elucidate a novel mechanism of inflammation-associated osteoclastogenesis, which involves TLR4 recognition of gamma-glutamyltranspeptidase and subsequent activation of MyD88-dependent signaling. | γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.
Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S., Free PMC Article | 05/5/2018 |
| the present study developed a liver-specific GGT-overexpressing mice model and found that GGT elevation in short term had no effects on glucose metabolism but could increase insulin sensitivity through enhancing the activity of insulin signaling pathway. | Liver-Specific Overexpression of Gamma-Glutamyltransferase Ameliorates Insulin Sensitivity of Male C57BL/6 Mice.
Long Y, Jia D, Wei L, Yang Y, Tian H, Chen T., Free PMC Article | 04/14/2018 |
| Statins can significantly decrease the expression of GGT in aortic atherosclerotic plaques of ApoE-knockout mice. | Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E-knockout mice.
Li G, Wu XW, Lu WH, Ai R, Chen F, Tang ZZ., Free PMC Article | 05/23/2015 |
| Gamma-glutamyltransferase levels are an independent predictor of worsening kidney function and mortality in acute heart failure patients. | Cardio-reno-hepatic interactions in acute heart failure: the role of γ-glutamyl transferase.
Parissis JT, Farmakis D, Andreoli C, Rafouli-Stergiou P, Ambrosio G, Anastasiou-Nana M, Filippatos G. | 12/20/2014 |
| Disruption of the Mrds1/Ofcc1 gene elicits asymptomatic hyper-gamma-glutamyl-transpeptidasemia in mice. | Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice.
Ohnishi T, Yamada K, Watanabe A, Ohba H, Sakaguchi T, Honma Y, Iwayama Y, Toyota T, Maekawa M, Watanabe K, Detera-Wadleigh SD, Wakana S, Yoshikawa T., Free PMC Article | 05/12/2012 |
| Mutations in the Ggt1 gene are responsible for the phenotypes of dwg/dwg and dwg(Bayer)/dwg(Bayer) mice. | Characterization of the dwg mutations: dwg and dwg(Bayer) are new mutant alleles of the Ggt1 gene.
Tsuji T, Yamada K, Kunieda T. | 03/29/2010 |
| GGT stimulates RANKL expression | Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.
Niida S, Kawahara M, Ishizuka Y, Ikeda Y, Kondo T, Hibi T, Suzuki Y, Ikeda K, Taniguchi N. | 01/21/2010 |
| Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia | Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.
Jean JC, Liu Y, Brown LA, Marc RE, Klings E, Joyce-Brady M. | 01/21/2010 |
| GGT is implicated as being involved in diseases characterized by accelerated osteoclast development and bone destruction. | Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis.
Hiramatsu K, Asaba Y, Takeshita S, Nimura Y, Tatsumi S, Katagiri N, Niida S, Nakajima T, Tanaka S, Ito M, Karsenty G, Ikeda K. | 01/21/2010 |
| GGT regulates osteoclast biology at least partly independently of sex steroids | Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.
Levasseur R, Barrios R, Elefteriou F, Glass DA 2nd, Lieberman MW, Karsenty G. | 01/21/2010 |
| prooxidant reactions mediated by gamma-GT in turn regulate the levels of tyrosinase in pigment cells. | Gamma-glutamyl transpeptidase and its role in melanogenesis: redox reactions and regulation of tyrosinase.
Chaubal VA, Nair SS, Ito S, Wakamatsu K, Mojamdar MV. | 01/21/2010 |