| CK1epsilon drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/beta-catenin pathway. | CK1ε drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/β-catenin pathway.
Yu Z, Jiang X, Yin J, Han L, Xiong C, Huo Z, Xu J, Shang J, Xi K, Nong L, Huang Y, Zhou X., Free PMC Article | 10/24/2023 |
| Cytoplasmic CK1epsilon Protein Expression Is Correlated With Distant Metastasis and Survival in Patients With Melanoma. | Cytoplasmic CK1ε Protein Expression Is Correlated With Distant Metastasis and Survival in Patients With Melanoma.
Lu JW, Lin SH, Yeh CM, Yeh KT, Huang LR, Chen CY, Lin YM., Free PMC Article | 07/3/2021 |
| Novel Insights into the Biochemical Mechanism of CK1epsilon and its Functional Interplay with DDX3X. | Novel Insights into the Biochemical Mechanism of CK1ε and its Functional Interplay with DDX3X.
Bono B, Franco G, Riva V, Garbelli A, Maga G., Free PMC Article | 04/3/2021 |
| The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling. | The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M. | 03/20/2021 |
| Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway. | Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway.
He T, Wu D, He L, Wang X, Yang B, Li S, Chen Y, Wang K, Chen R, Liu B, Zhang L, Rong L. | 01/23/2021 |
| CRISPR-mediated gene targeting of CK1delta/epsilon leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1. | CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.
Guillen RX, Beckley JR, Chen JS, Gould KL., Free PMC Article | 12/5/2020 |
| FENDRR reduces tumor invasiveness in prostate cancer PC-3 cells by targeting CSNK1E. | FENDRR reduces tumor invasiveness in prostate cancer PC-3 cells by targeting CSNK1E.
Zhang YQ, Chen X, Fu CL, Zhang W, Zhang DL, Pang C, Liu M, Wang JY. | 10/10/2020 |
| Human Rad17 is constitutively phosphorylated in vivo on a C-terminal threonine, T670. Rad17-T670 is phosphorylated by casein kinase 1delta/epsilon. | Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1δ/ε and CK2 to promote interaction with the 9-1-1 complex.
Fukumoto Y, Nakayama Y, Yamaguchi N. | 06/13/2020 |
| LINC00673-v4 augmented the interaction between DDX3 and CK1epsilon and thus the phosphorylation of dishevelled, which subsequently activated WNT/beta-catenin signaling and consequently caused aggressiveness of lung adenocarcinoma (LAD) | Long noncoding RNA LINC00673-v4 promotes aggressiveness of lung adenocarcinoma via activating WNT/β-catenin signaling.
Guan H, Zhu T, Wu S, Liu S, Liu B, Wu J, Cai J, Zhu X, Zhang X, Zeng M, Li J, Song E, Li M., Free PMC Article | 04/4/2020 |
| This study supported the potential role of CSNK1E variants in epileptic encephalopathy susceptibility. | A de novo pathogenic CSNK1E mutation identified by exome sequencing in family trios with epileptic encephalopathy.
Chen X, Jin J, Wang Q, Xue H, Zhang N, Du Y, Zhang T, Zhang B, Wu J, Liu Z. | 03/28/2020 |
| casein kinase 1epsilon (CK1epsilon) was identified as a novel target of REGgamma and knockdown of CK1epsilon effectively abolished the effect of REGgamma depletion on renal cell carcinoma cells growth. | REGγ deficiency suppresses tumor progression via stabilizing CK1ε in renal cell carcinoma.
Chen S, Wang Q, Wang L, Chen H, Gao X, Gong D, Ma J, Kubra S, Yao X, Li X, Li L, Zhai W, Zheng J., Free PMC Article | 12/14/2019 |
| results demonstrate that CK1epsilon regulates the survival of glioblastoma cells and glioblastoma stem cells through beta-catenin signaling, underscoring the importance of targeting CK1epsilon as an effective treatment for glioblastoma. | Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival.
Varghese RT, Young S, Pham L, Liang Y, Pridham KJ, Guo S, Murphy S, Kelly DF, Sheng Z., Free PMC Article | 10/26/2019 |
| These data suggest that CK1epsilon is involved in the regulation of tau phosphorylation, the alternative splicing of tau exon 10, and cognitive performance. Up-regulation of CK1epsilon might contribute to tau pathology by hyperphosphorylating tau and by dysregulating the alternative splicing of tau exon 10 in AD. | Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease.
Chen C, Gu J, Basurto-Islas G, Jin N, Wu F, Gong CX, Iqbal K, Liu F., Free PMC Article | 07/6/2019 |
| In silico modeling and in vitro biophysical methods explain how CK1epsilon-specific phosphorylation events control conformational dynamics of DVL3 in living cells upon Wnt pathway stimulation via modulation of the PDZ domain and its interaction with DVL3 C-terminus. | Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1.
Harnoš J, Cañizal MCA, Jurásek M, Kumar J, Holler C, Schambony A, Hanáková K, Bernatík O, Zdráhal Z, Gömöryová K, Gybeľ T, Radaszkiewicz TW, Kravec M, Trantírek L, Ryneš J, Dave Z, Fernández-Llamazares AI, Vácha R, Tripsianes K, Hoffmann C, Bryja V., Free PMC Article | 06/1/2019 |
| DDX3X is required for full CK1 activity in living cells. Phosphorylation by CK1 impairs the ATPase activity of DDX3X and RNA destabilizes the DDX3X-CK1 complex. | A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε.
Dolde C, Bischof J, Grüter S, Montada A, Halekotte J, Peifer C, Kalbacher H, Baumann U, Knippschild U, Suter B., Free PMC Article | 04/27/2019 |
| CK1epsilon is activated by noncanonical Wnt and identify p120-catenin and CK1epsilon as two critical factors controlling Ror2 function. | CK1ε and p120-catenin control Ror2 function in noncanonical Wnt signaling.
Curto J, Del Valle-Pérez B, Villarroel A, Fuertes G, Vinyoles M, Peña R, García de Herreros A, Duñach M., Free PMC Article | 03/30/2019 |
| propose a model in which AXIN1 competes with dishevelled (DVL) for CK1 and regulates CK1-induced phosphorylation of DVL and activation of Wnt/beta-catenin signaling. | Analysis of binding interfaces of the human scaffold protein AXIN1 by peptide microarrays.
Harnoš J, Ryneš J, Víšková P, Foldynová-Trantírková S, Bajard-Ešner L, Trantírek L, Bryja V., Free PMC Article | 03/23/2019 |
| CSNK1E SNP rs2075984 seemed to play a significant role in the development of bipolar disorder in this Korean sample. | Genetic association study of CSNK1E gene in bipolar disorder and circadian characteristics.
Lee KY, Ahn YM, Kim SH, Kang HG, Joo EJ. | 03/23/2019 |
| Findings in the dorsolateral prefrontal cortex in schizophrenia provide evidence of altered proteins involved in synaptic function (FABP4), cytoarchitecture organization (NEFH), and circadian molecular clock signaling (CSNK1E), which may be contributing to the cognitive and/or negative symptoms in this disorder. FABP4, CSNK1E and NEFH could become potentially useful biomarkers for schizophrenia. | Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia.
Pinacho R, Villalmanzo N, Meana JJ, Ferrer I, Berengueras A, Haro JM, Villén J, Ramos B. | 01/6/2018 |
| low CK1epsilon expression is correlated with a low survival rate and CK1epsilon may play a role as a tumor suppressor in hepatocarcinogenesis. | Low cytoplasmic casein kinase 1 epsilon expression predicts poor prognosis in patients with hepatocellular carcinoma.
Lin SH, Yeh CM, Hsieh MJ, Lin YM, Chen MW, Chen CJ, Lin CY, Hung HF, Yeh KT, Yang SF. | 02/18/2017 |
| Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3. | The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3.
Zhou Y, He C, Yan D, Liu F, Liu H, Chen J, Cao T, Zuo M, Wang P, Ge Y, Lu H, Tong Q, Qin C, Deng Y, Ge B. | 08/13/2016 |
| CSNK1E expression is associated with disease-free survival in breast cancer patients with wild-type p53 or poor histological differentiation or in those without adjuvant chemotherapy. | High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer.
Lopez-Guerra JL, Verdugo-Sivianes EM, Otero-Albiol D, Vieites B, Ortiz-Gordillo MJ, De León JM, Praena-Fernandez JM, Marin JJ, Carnero A., Free PMC Article | 08/6/2016 |
| a 4-locus CSNK1E haplotype encompassing the rs1534891 SNP (Z-score=2.685, permuted p=0.0076) and a 3-locus haplotype in ARNTL (Z-score=3.269, permuted p=0.0011) showed a significant association with Bipolar Disorder | Identification of circadian gene variants in bipolar disorder in Latino populations.
Gonzalez R, Gonzalez S, Villa E, Ramirez M, Zavala J, Armas R, Contreras J, Dassori A, Leach RJ, Flores D, Jerez A, Raventós H, Ontiveros A, Nicolini H, Escamilla M. | 05/7/2016 |
| site-specific phosphorylation of adiponectin, especially at sites targeted by CK1delta in vitro, provides an additional regulatory mechanism for modulating adiponectin complex formation and function. | Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin.
Xu P, Fischer-Posovszky P, Bischof J, Radermacher P, Wabitsch M, Henne-Bruns D, Wolf AM, Hillenbrand A, Knippschild U. | 12/12/2015 |
| The dynamical and conformational properties for each of three isoforms of CK1 are explored through molecular dynamics (MD) simulations. | A comparative study of structural and conformational properties of casein kinase-1 isoforms: insights from molecular dynamics and principal component analysis.
Singh SP, Gupta DK. | 12/12/2015 |