| Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve. | Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve.
Piñeiro-Sabarís R, MacGrogan D, de la Pompa JL., Free PMC Article | 10/31/2024 |
| A CEBPB/miR-32-5p/GATA6 axis promotes vascular calcification in type 2 diabetes. | A CEBPB/miR-32-5p/GATA6 axis promotes vascular calcification in type 2 diabetes.
Zhao Z, Li A, Zeng R, Zeng Z, Ou L, Cao J, Liu J. | 08/19/2024 |
| Mis-expression of GATA6 re-programs cell fate during early hematopoiesis. | Mis-expression of GATA6 re-programs cell fate during early hematopoiesis.
Audiger C, Laâbi Y, Nie J, Gibson L, Wilson-Annan J, Brook-Carter P, Kueh A, Harris AW, Naik S, Nutt SL, Strasser A, Adams JM, Bouillet P, Chopin M. | 06/14/2024 |
| The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair. | The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair.
Li X, Liu A, Xie C, Chen Y, Zeng K, Xie C, Zhang Z, Luo P, Huang H. | 01/8/2024 |
| Control of murine brown adipocyte development by GATA6. | Control of murine brown adipocyte development by GATA6.
Jun S, Angueira AR, Fein EC, Tan JME, Weller AH, Cheng L, Batmanov K, Ishibashi J, Sakers AP, Stine RR, Seale P., | 11/13/2023 |
| Modulating the m6A Modified Transcription Factor GATA6 Impacts Epithelial Cytokines in Acute Lung Injury. | Modulating the m6A Modified Transcription Factor GATA6 Impacts Epithelial Cytokines in Acute Lung Injury.
Jin A, Li L, Zhao Y, Li M, Zhang S, Chen J, Li Y, Huang L, Ren H, Lu S, Yang X, Sun Q. | 11/3/2023 |
| Endothelial Gata6 deletion reduces monocyte recruitment and proinflammatory macrophage formation and attenuates atherosclerosis through Cmpk2-Nlrp3 pathways. | Endothelial Gata6 deletion reduces monocyte recruitment and proinflammatory macrophage formation and attenuates atherosclerosis through Cmpk2-Nlrp3 pathways.
Wu W, Bao W, Chen X, Lu Y, Fang J, Liu J, Peng S, Pi J, Tomlinson B, Chan P, Zhang Q, Zhang L, Liu Z, Liu J, Zhang Y, Zhuang T., Free PMC Article | 07/14/2023 |
| GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension. | GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension.
Toyama T, Kudryashova TV, Ichihara A, Lenna S, Looney A, Shen Y, Jiang L, Teos L, Avolio T, Lin D, Kaplan U, Marden G, Dambal V, Goncharov D, Delisser H, Lafyatis R, Seta F, Goncharova EA, Trojanowska M., Free PMC Article | 05/4/2023 |
| A GATA6-centred gene regulatory network involving HNFs and DeltaNp63 controls plasticity and immune escape in pancreatic cancer. | A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer.
Kloesch B, Ionasz V, Paliwal S, Hruschka N, Martinez de Villarreal J, Öllinger R, Mueller S, Dienes HP, Schindl M, Gruber ES, Stift J, Herndler-Brandstetter D, Lomberk GA, Seidler B, Saur D, Rad R, Urrutia RA, Real FX, Martinelli P., Free PMC Article | 05/14/2022 |
| GATA6 Deficiency Leads to Epithelial Barrier Dysfunction and Enhances Susceptibility to Gut Inflammation. | GATA6 Deficiency Leads to Epithelial Barrier Dysfunction and Enhances Susceptibility to Gut Inflammation.
Laudisi F, Stolfi C, Bevivino G, Maresca C, Franzè E, Troncone E, Lolli E, Marafini I, Pietrucci D, Teofani A, Di Grazia A, Di Fusco D, Colantoni A, Ortenzi A, Desideri A, Monteleone I, Monteleone G. | 02/26/2022 |
| Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury. | Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury.
Honda M, Kadohisa M, Yoshii D, Komohara Y, Hibi T., Free PMC Article | 01/22/2022 |
| Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis. | Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis.
Dittrich GM, Froese N, Wang X, Kroeger H, Wang H, Szaroszyk M, Malek-Mohammadi M, Cordero J, Keles M, Korf-Klingebiel M, Wollert KC, Geffers R, Mayr M, Conway SJ, Dobreva G, Bauersachs J, Heineke J., Free PMC Article | 12/11/2021 |
| A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity. | A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity.
Bernhardt L, Dittrich M, El-Merahbi R, Saliba AE, Müller T, Sumara G, Vogel J, Nichols-Burns S, Mitchell M, Haaf T, El Hajj N., Free PMC Article | 10/2/2021 |
| Variants in a cis-regulatory element of TBX1 in conotruncal heart defect patients impair GATA6-mediated transactivation. | Variants in a cis-regulatory element of TBX1 in conotruncal heart defect patients impair GATA6-mediated transactivation.
Jiang X, Li T, Liu S, Fu Q, Li F, Chen S, Sun K, Xu R, Xu Y., Free PMC Article | 09/18/2021 |
| GATA6 is a regulator of sinus node development and heart rhythm. | GATA6 is a regulator of sinus node development and heart rhythm.
Gharibeh L, Yamak A, Whitcomb J, Lu A, Joyal M, Komati H, Liang W, Fiset C, Nemer M., Free PMC Article | 05/8/2021 |
| EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6. | EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6.
Patil S, Steuber B, Kopp W, Kari V, Urbach L, Wang X, Küffer S, Bohnenberger H, Spyropoulou D, Zhang Z, Versemann L, Bösherz MS, Brunner M, Gaedcke J, Ströbel P, Zhang JS, Neesse A, Ellenrieder V, Singh SK, Johnsen SA, Hessmann E. | 02/6/2021 |
| Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6. | Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6.
Arnal-Estapé A, Cai WL, Albert AE, Zhao M, Stevens LE, López-Giráldez F, Patel KD, Tyagi S, Schmitt EM, Westbrook TF, Nguyen DX., Free PMC Article | 12/5/2020 |
| Altogether, these findings support a role for Gata6 in maintaining proper upper hair follicle morphology. | Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct.
Swanson JB, Vagnozzi AN, Veniaminova NA, Wong SY., Free PMC Article | 05/30/2020 |
| role of TCF7L2 in regulation of vascular smooth muscle cell plasticity and protection against arterial disease. | TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia.
Srivastava R, Rolyan H, Xie Y, Li N, Bhat N, Hong L, Esteghamat F, Adeniran A, Geirsson A, Zhang J, Ge G, Nobrega M, Martin KA, Mani A., Free PMC Article | 12/7/2019 |
| The results suggested a second heart field regulatory network comprising of Gata4, Gata6 and SHh-signaling for outflow tract development. | Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.
Liu J, Cheng H, Xiang M, Zhou L, Wu B, Moskowitz IP, Zhang K, Xie L., Free PMC Article | 12/7/2019 |
| GATA6 haploinsufficiency leads to right-left type bicuspid aortic valve by disrupting valve remodeling and extracellular matrix composition. | GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.
Gharibeh L, Komati H, Bossé Y, Boodhwani M, Heydarpour M, Fortier M, Hassanzadeh R, Ngu J, Mathieu P, Body S, Nemer M, Bicuspid Aortic Valve Consortium., Free PMC Article | 09/21/2019 |
| Etv5 can positively regulate primitive endoderm specification through regulating Gata6 and negatively regulate epiblast specification by inhibiting Fgf5 expression. | The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.
Zhang J, Cao H, Xie J, Fan C, Xie Y, He X, Liao M, Zhang S, Wang H., Free PMC Article | 09/14/2019 |
| The long non-coding antisense transcript of GATA6 (GATA6-AS) interacts with the epigenetic regulator LOXL2 to regulate endothelial gene expression via changes in histone methylation. A number of angiogenesis- and hypoxia-related genes were downregulated by GATA6-AS silencing. Silencing of GATA6-AS diminishes TGF-beta2-induced endothelial-mesenchymal transition in vitro and promotes formation of blood vessels in mice. | The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2.
Neumann P, Jaé N, Knau A, Glaser SF, Fouani Y, Rossbach O, Krüger M, John D, Bindereif A, Grote P, Boon RA, Dimmeler S., Free PMC Article | 12/22/2018 |
| Gata6 could be utilized as a biomarker to select the best Pluripotent stem cell (PSC) lines to produce PSC-derived cardiomyocytes. | Gata6 in pluripotent stem cells enhance the potential to differentiate into cardiomyocytes.
Yoon CH, Kim TW, Koh SJ, Choi YE, Hur J, Kwon YW, Cho HJ, Kim HS., Free PMC Article | 08/18/2018 |
| GATA4/6 are key regulators of steroidogenesis and testicular somatic cell survival. | Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors.
Penny GM, Cochran RB, Pihlajoki M, Kyrönlahti A, Schrade A, Häkkinen M, Toppari J, Heikinheimo M, Wilson DB., Free PMC Article | 06/16/2018 |