| PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells. | PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
Katerndahl CDS, Rogers ORS, Day RB, Xu Z, Helton NM, Ramakrishnan SM, Miller CA, Ley TJ., Free PMC Article | 05/7/2024 |
| Perturbed collagen metabolism underlies lymphatic recanalization failure in Gata2 heterozygous deficient mice. | Perturbed collagen metabolism underlies lymphatic recanalization failure in Gata2 heterozygous deficient mice.
Watanabe-Asaka T, Hayashi M, Harada T, Uemura S, Takai J, Nakamura Y, Moriguchi T, Kawai Y. | 05/2/2024 |
| Gata2 noncoding genetic variation as a determinant of hematopoietic stem/progenitor cell mobilization efficiency. | Gata2 noncoding genetic variation as a determinant of hematopoietic stem/progenitor cell mobilization efficiency.
Soukup AA, Bresnick EH., Free PMC Article | 12/28/2023 |
| GATA2 mitotic bookmarking is required for definitive haematopoiesis. | GATA2 mitotic bookmarking is required for definitive haematopoiesis.
Silvério-Alves R, Kurochkin I, Rydström A, Vazquez Echegaray C, Haider J, Nicholls M, Rode C, Thelaus L, Lindgren AY, Ferreira AG, Brandão R, Larsson J, de Bruijn MFTR, Martin-Gonzalez J, Pereira CF., Free PMC Article | 08/16/2023 |
| Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis. | Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis.
Tenney AP, Di Gioia SA, Webb BD, Chan WM, de Boer E, Garnai SJ, Barry BJ, Ray T, Kosicki M, Robson CD, Zhang Z, Collins TE, Gelber A, Pratt BM, Fujiwara Y, Varshney A, Lek M, Warburton PE, Van Ryzin C, Lehky TJ, Zalewski C, King KA, Brewer CC, Thurm A, Snow J, Facio FM, Narisu N, Bonnycastle LL, Swift A, Chines PS, Bell JL, Mohan S, Whitman MC, Staffieri SE, Elder JE, Demer JL, Torres A, Rachid E, Al-Haddad C, Boustany RM, Mackey DA, Brady AF, Fenollar-Cortés M, Fradin M, Kleefstra T, Padberg GW, Raskin S, Sato MT, Orkin SH, Parker SCJ, Hadlock TA, Vissers LELM, van Bokhoven H, Jabs EW, Collins FS, Pennacchio LA, Manoli I, Engle EC., Free PMC Article | 07/19/2023 |
| Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition. | Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition.
Koyunlar C, Gioacchino E, Vadgama D, de Looper H, Zink J, Ter Borg MND, Hoogenboezem R, Havermans M, Sanders MA, Bindels E, Dzierzak E, Touw IP, de Pater E., Free PMC Article | 05/18/2023 |
| GATA2 promotes oxidative stress to aggravate renal ischemia-reperfusion injury by up-regulating Redd1. | GATA2 promotes oxidative stress to aggravate renal ischemia-reperfusion injury by up-regulating Redd1.
Huang D, Chen D, Hu T, Liang H. | 01/28/2023 |
| Transcription factor GATA2 may potentiate follicle-stimulating hormone production in mice via induction of the BMP antagonist gremlin in gonadotrope cells. | Transcription factor GATA2 may potentiate follicle-stimulating hormone production in mice via induction of the BMP antagonist gremlin in gonadotrope cells.
Schang G, Ongaro L, Brûlé E, Zhou X, Wang Y, Boehm U, Ruf-Zamojski F, Zamojski M, Mendelev N, Seenarine N, Amper MA, Nair V, Ge Y, Sealfon SC, Bernard DJ., Free PMC Article | 07/30/2022 |
| Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding. | Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding.
Hasegawa A, Hayasaka Y, Morita M, Takenaka Y, Hosaka Y, Hirano I, Yamamoto M, Shimizu R., Free PMC Article | 04/30/2022 |
| Specific effects of somatic GATA2 zinc finger mutations on erythroid differentiation. | Specific effects of somatic GATA2 zinc finger mutations on erythroid differentiation.
Redondo Monte E, Leubolt G, Windisch R, Kerbs P, Dutta S, Landspersky T, Istvánffy R, Oostendorp RAJ, Chen-Wichmann L, Herold T, Cusan M, Schotta G, Wichmann C, Greif PA. | 04/9/2022 |
| E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates. | E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates.
Wanet A, Bassal MA, Patel SB, Marchi F, Mariani SA, Ahmed N, Zhang H, Borchiellini M, Chen S, Zhang J, Di Ruscio A, Miyake K, Tsai M, Paranjape A, Park SY, Karasuyama H, Schroeder T, Dzierzak E, Galli SJ, Tenen DG, Welner RS., Free PMC Article | 03/5/2022 |
| Cell-cycle dependent GATA2 subcellular localization in mouse 2-cell embryos. | Cell-cycle dependent GATA2 subcellular localization in mouse 2-cell embryos.
Komatsu M, Tsukahara H, Bai H, Takahashi M, Wakai T, Kawahara M. | 01/8/2022 |
| Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development. | Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development.
Bresciani E, Carrington B, Yu K, Kim EM, Zhen T, Guzman VS, Broadbridge E, Bishop K, Kirby M, Harper U, Wincovitch S, Dell'Orso S, Sartorelli V, Sood R, Liu P., Free PMC Article | 01/8/2022 |
| Tumor suppressor function of Gata2 in acute promyelocytic leukemia. | Tumor suppressor function of Gata2 in acute promyelocytic leukemia.
Katerndahl CDS, Rogers ORS, Day RB, Cai MA, Rooney TP, Helton NM, Hoock M, Ramakrishnan SM, Nonavinkere Srivatsan S, Wartman LD, Miller CA, Ley TJ., Free PMC Article | 12/18/2021 |
| Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model. | Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model.
Fu YK, Tan Y, Wu B, Dai YT, Xu XG, Pan MM, Chen ZW, Qiao N, Wu J, Jiang L, Lu J, Chen B, Rein A, Izraeli S, Sun XJ, Huang JY, Huang QH, Chen Z, Chen SJ., Free PMC Article | 10/16/2021 |
| GATA2 participates in the recanalization of lymphatic vessels after surgical lymph node extirpation. | GATA2 participates in the recanalization of lymphatic vessels after surgical lymph node extirpation.
Watanabe-Asaka T, Hayashi M, Uemura S, Takai J, Suzuki A, Moriguchi T, Kawai Y. | 09/4/2021 |
| Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages. | Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages.
Yin C, Vrieze AM, Rosoga M, Akingbasote J, Pawlak EN, Jacob RA, Hu J, Sharma N, Dikeakos JD, Barra L, Nagpal AD, Heit B., Free PMC Article | 06/26/2021 |
| EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis. | EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis.
Yamaoka A, Suzuki M, Katayama S, Orihara D, Engel JD, Yamamoto M., Free PMC Article | 06/19/2021 |
| A Novel GATA2 Protein Reporter Mouse Reveals Hematopoietic Progenitor Cell Types. | A Novel GATA2 Protein Reporter Mouse Reveals Hematopoietic Progenitor Cell Types.
Ahmed N, Kunz L, Hoppe PS, Loeffler D, Etzrodt M, Ortega GC, Hilsenbeck O, Anastassiadis K, Schroeder T., Free PMC Article | 06/5/2021 |
| GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers. | GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers.
Li Y, Gao J, Kamran M, Harmacek L, Danhorn T, Leach SM, O'Connor BP, Hagman JR, Huang H., Free PMC Article | 02/13/2021 |
| Gata2 deficiency delays leukemogenesis while contributing to aggressive leukemia phenotype in Cbfb-MYH11 knockin mice. | Gata2 deficiency delays leukemogenesis while contributing to aggressive leukemia phenotype in Cbfb-MYH11 knockin mice.
Saida S, Zhen T, Kim E, Yu K, Lopez G, McReynolds LJ, Liu PP., Free PMC Article | 08/29/2020 |
| GATA2 acts as a critical regulator of normal and leukemic stem cells and mediates transcriptional networks that may be exploited therapeutically to target key facets of leukemic stem cells behavior in acute myeloid leukemia. | Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia.
Menendez-Gonzalez JB, Vukovic M, Abdelfattah A, Saleh L, Almotiri A, Thomas LA, Agirre-Lizaso A, Azevedo A, Menezes AC, Tornillo G, Edkins S, Kong K, Giles P, Anjos-Afonso F, Tonks A, Boyd AS, Kranc KR, Rodrigues NP., Free PMC Article | 04/25/2020 |
| Study identified GATA2 as a feedback inhibitor of retinoic acid signalling important for precise onset of ureteric smooth muscle cell differentiation. | Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme.
Weiss AC, Bohnenpoll T, Kurz J, Blank P, Airik R, Lüdtke TH, Kleppa MJ, Deuper L, Kaiser M, Mamo TM, Costa R, von Hahn T, Trowe MO, Kispert A. | 04/18/2020 |
| Results suggest that PU.1 and LDB1 play central roles in the formation of active chromatin structure whereas GATA2 directly activates the Ms4a2 promoter. | GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse Ms4a2 Gene, Encoding FcεRIβ, through Distinct Mechanisms.
Ohmori S, Ishijima Y, Numata S, Takahashi M, Sekita M, Sato T, Chugun K, Yamamoto M, Ohneda K., Free PMC Article | 02/29/2020 |
| Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer. | Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.
Soukup AA, Zheng Y, Mehta C, Wu J, Liu P, Cao M, Hofmann I, Zhou Y, Zhang J, Johnson KD, Choi K, Keles S, Bresnick EH., Free PMC Article | 02/29/2020 |