| GAS6 and AXL Promote Insulin Resistance by Rewiring Insulin Signaling and Increasing Insulin Receptor Trafficking to Endosomes. | GAS6 and AXL Promote Insulin Resistance by Rewiring Insulin Signaling and Increasing Insulin Receptor Trafficking to Endosomes.
Schott C, Germain A, Lacombe J, Pata M, Faubert D, Boulais J, Carmeliet P, Côté JF, Ferron M. | 09/27/2024 |
| Modification of Gas6 Protein in the Brain by a Functional Endogenous Tissue Vitamin K Cycle. | Modification of Gas6 Protein in the Brain by a Functional Endogenous Tissue Vitamin K Cycle.
Aydin N, Ouliass B, Ferland G, Hafizi S., Free PMC Article | 09/6/2024 |
| Gas6 and Protein S Ligands Cooperate to Regulate MerTK Rhythmic Activity Required for Circadian Retinal Phagocytosis. | Gas6 and Protein S Ligands Cooperate to Regulate MerTK Rhythmic Activity Required for Circadian Retinal Phagocytosis.
Parinot C, Chatagnon J, Rieu Q, Roux S, Néel D, Hamieh F, Nandrot EF., Free PMC Article | 07/3/2024 |
| GAS6 attenuates sepsis-induced cardiac dysfunction through NLRP3 inflammasome-dependent mechanism. | GAS6 attenuates sepsis-induced cardiac dysfunction through NLRP3 inflammasome-dependent mechanism.
Ji T, Liu Q, Yu L, Lei W, Lu C, Chen J, Xie X, Zhang Z, Liang Z, Deng C, Chen Y, Ren J, Yang Y. | 12/29/2023 |
| Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice. | Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice.
Tang J, Jin Y, Jia F, Lv T, Manaenko A, Zhang LF, Zhang Z, Qi X, Xue Y, Zhao B, Zhang X, Zhang JH, Lu J, Hu Q. | 11/15/2023 |
| Gas6 Exerts Neuroprotective Effects via Restoring the Blood-Brain Barrier in Mice with Sepsis-Associated Encephalopathy. | Gas6 Exerts Neuroprotective Effects via Restoring the Blood-Brain Barrier in Mice with Sepsis-Associated Encephalopathy.
Li HX, Ni JJ, Zhang LX, Liu JY. | 07/17/2023 |
| AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells. | AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells.
Pop OT, Geng A, Flint E, Singanayagam A, Ercan C, Possamai L, Patel VC, Kuenzler P, Meier MA, Soysal S, Hruz P, Kollmar O, Tatham KC, Ward JK, Müllhaupt B, Weber A, Wendon J, Niess JH, Heim M, Semela D, Weston C, Antoniades CG, Terracciano LM, Triantafyllou E, Brenig RG, Bernsmeier C., Free PMC Article | 06/26/2023 |
| Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver. | Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver.
Tsugawa H, Ohki T, Tsubaki S, Tanaka R, Matsuzaki J, Suzuki H, Hozumi K., Free PMC Article | 06/21/2023 |
| Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis. | Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis.
Yao Z, Qi W, Zhang H, Zhang Z, Liu L, Shao Y, Zeng H, Yin J, Pan H, Guo X, Liu A, Cai D, Bai X, Zhang H., Free PMC Article | 05/19/2023 |
| Early death in a mouse model of Alzheimer's disease exacerbated by microglial loss of TAM receptor signaling. | Early death in a mouse model of Alzheimer's disease exacerbated by microglial loss of TAM receptor signaling.
Huang Y, Lemke G., Free PMC Article | 01/11/2023 |
| Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease. | Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease.
Owlett LD, Karaahmet B, Le L, Belcher EK, Dionisio-Santos D, Olschowka JA, Elliott MR, O'Banion MK., Free PMC Article | 07/16/2022 |
| Growth arrest-specific 6 modulates adiponectin expression and insulin resistance in adipose tissue. | Growth arrest-specific 6 modulates adiponectin expression and insulin resistance in adipose tissue.
Su SC, Chiang CF, Hsieh CH, Lu GH, Liu JS, Shieh YS, Hung YJ, Lee CH., Free PMC Article | 02/5/2022 |
| GAS6 ameliorates advanced age-associated meiotic defects in mouse oocytes by modulating mitochondrial function. | GAS6 ameliorates advanced age-associated meiotic defects in mouse oocytes by modulating mitochondrial function.
Kim KH, Kim EY, Lee KA., Free PMC Article | 12/18/2021 |
| MRP8/14 mediates macrophage efferocytosis through RAGE and Gas6/MFG-E8, and induces polarization via TLR4-dependent pathway. | MRP8/14 mediates macrophage efferocytosis through RAGE and Gas6/MFG-E8, and induces polarization via TLR4-dependent pathway.
Li K, Chen G, Luo H, Li J, Liu A, Yang C, Wang J, Xu J, Gao S, Chen P, Jiang Y. | 09/11/2021 |
| Gas6 negatively regulates the Staphylococcus aureus-induced inflammatory response via TLR signaling in the mouse mammary gland. | Gas6 negatively regulates the Staphylococcus aureus-induced inflammatory response via TLR signaling in the mouse mammary gland.
Zahoor A, Yang Y, Yang C, Akhtar M, Guo Y, Shaukat A, Guo MY, Deng G. | 03/13/2021 |
| Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization. | Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization.
Shibata T, Makino A, Ogata R, Nakamura S, Ito T, Nagata K, Terauchi Y, Oishi T, Fujieda M, Takahashi Y, Ato M., Free PMC Article | 02/6/2021 |
| Gas6 or Mer deficiency ameliorates silica-induced autophagosomes accumulation in mice lung. | Gas6 or Mer deficiency ameliorates silica-induced autophagosomes accumulation in mice lung.
Li W, Xie L, Ma J, Cheng M, Fan L, Xu Y, Wang B, Chen W. | 01/16/2021 |
| Gamma-glutamyl carboxylated Gas6 mediates the beneficial effect of vitamin K on lowering hyperlipidemia via regulating the AMPK/SREBP1/PPARalpha signaling cascade of lipid metabolism. | Gamma-glutamyl carboxylated Gas6 mediates the beneficial effect of vitamin K on lowering hyperlipidemia via regulating the AMPK/SREBP1/PPARα signaling cascade of lipid metabolism.
Bordoloi J, Ozah D, Bora T, Kalita J, Manna P. | 11/21/2020 |
| Gas6 is a reciprocal regulator of mitophagy during mammalian oocyte maturation. | Gas6 is a reciprocal regulator of mitophagy during mammalian oocyte maturation.
Kim KH, Kim EY, Ko JJ, Lee KA., Free PMC Article | 10/24/2020 |
| Deletion of Axl disables testosterone, which indicates that Axl is an important downstream regulator of testosterone. | Exogenous testosterone alleviates cardiac fibrosis and apoptosis via Gas6/Axl pathway in the senescent mice.
Chen FF, Song FQ, Chen YQ, Wang ZH, Li YH, Liu MH, Li Y, Song M, Zhang W, Zhao J, Zhong M. | 06/6/2020 |
| activation of STAT6-mediated Gas6 expression during macrophage phenotype transition resulting in efferocytosis of neutrophils plays a crucial role in the resolution of inflammatory lung injury. | STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation.
Nepal S, Tiruppathi C, Tsukasaki Y, Farahany J, Mittal M, Rehman J, Prockop DJ, Malik AB., Free PMC Article | 03/28/2020 |
| Gas6 exerts an anti-inflammatory effect in a mouse model of autoimmune thyroiditis and may therefore be a potential therapeutic target. | Growth arrest-specific protein 6 (Gas6) attenuates inflammatory injury and apoptosis in iodine-induced NOD.H-2(h4) mice.
Sun X, Guan H, Peng S, Zhao Y, Zhang L, Wang X, Li C, Shan Z, Teng W. | 02/1/2020 |
| Pretreatment of alveolar epithelial cells (ECs) with Gas6 inhibited TGF-beta1-induced epithelial-mesenchymal transition (EMT). Gas6 enhanced the levels of COX-2-derived PGE2 and PGD2 as well as of their receptors. Knockdown of Axl or Mer reversed the enhancement of PGE2 and PGD2 and suppression of EMT, migration and invasion by Gas6. Data suggest Gas6-Axl or -Mer signalling events may reprogram ECs to resist EMT. | Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE(2), PGD(2) and Their Receptors.
Jung J, Lee YJ, Choi YH, Park EM, Kim HS, Kang JL., Free PMC Article | 01/11/2020 |
| Genetic deletion of Gas6 or Mer is protective against silica-induced lung inflammation and fibrosis in mice. | Genetic loss of Gas6/Mer pathway attenuates silica-induced lung inflammation and fibrosis in mice.
Li W, Xie L, Ma J, Yang M, Wang B, Xu Y, Fan L, Mu G, Shi T, Chen W. | 08/3/2019 |
| MerTK ligands Gas6 and Protein S are expressed in both RPE cells and photoreceptors, and at least one of them is required for phagocytosis to occur. With opposite effects on RPE phagocytosis and changes in their expression levels around the time of POS uptake, Gas6 and Protein S may contribute to the tight control of the acute phagocytic peak in the retina. Review. | Opposite Roles of MerTK Ligands Gas6 and Protein S During Retinal Phagocytosis.
Nandrot EF. | 05/11/2019 |