| Time-restricted feeding prevents metabolic diseases through the regulation of galanin/GALR1 expression in the hypothalamus of mice. | Time-restricted feeding prevents metabolic diseases through the regulation of galanin/GALR1 expression in the hypothalamus of mice.
Sun J, She Y, Fang P, Gu X, Zhang Z. | 05/21/2022 |
| These data demonstrate that Galanin (Gal) contributes not only to cholangiocyte proliferation but also to liver fibrogenesis via the coordinate activation of GalR1 in cholangiocytes and GalR2 in hepatic stellate cells (HSCs). | Coordinated Targeting of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells Ameliorates Liver Fibrosis in Multidrug Resistance Protein 2 Knockout Mice.
Petrescu AD, Grant S, Williams E, Frampton G, Parks N, Blaney H, Davies M, John R, Reinhart EH, McMillin M, DeMorrow S., Free PMC Article | 05/23/2020 |
| In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1, and the CB1 receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 muscarinic receptor subtypes was also analyzed in brain areas involved in anxiety and cognition. | Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease.
Manuel I, Lombardero L, LaFerla FM, Giménez-Llort L, Rodríguez-Puertas R. | 07/29/2017 |
| Galanin, acting via the GAL1 receptor and Gi -coupled signalling in L and K cells, is a potent inhibitor of GLP-1 and GIP secretion | Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells.
Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM., Free PMC Article | 12/17/2016 |
| endogenous Gal-1 may influence T. cruzi infection by fueling tolerogenic circuits that hinder anti-parasite immunity. | Trypanosoma cruzi Infection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1-Dependent Mechanisms.
Poncini CV, Ilarregui JM, Batalla EI, Engels S, Cerliani JP, Cucher MA, van Kooyk Y, González-Cappa SM, Rabinovich GA. | 02/6/2016 |
| Experiments with a GalR1-preffering galanin analog, NAX-5055, show that GalR1 is involved in regulating glucose and insulin homeostasis | Regulation of glucose and insulin release following acute and repeated treatment with the synthetic galanin analog NAX-5055.
Flynn SP, White HS., Free PMC Article | 01/16/2016 |
| two different models of chronic pain requires a galanin receptor 1-triggered depression of excitatory synaptic transmission in indirect pathway nucleus accumbens medium spiny neurons. | Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens.
Schwartz N, Temkin P, Jurado S, Lim BK, Heifets BD, Polepalli JS, Malenka RC., Free PMC Article | 08/16/2014 |
| GalR1 expression is increased in the nucleus accumbens after chronic restraint stress. | The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress.
Zhao X, Seese RR, Yun K, Peng T, Wang Z. | 03/1/2014 |
| Galanin opposes the actions of morphine which leads to opiate dependence and withdrawal, an effect that is mediated via GalR1 | Galanin negatively modulates opiate withdrawal via galanin receptor 1.
Holmes FE, Armenaki A, Iismaa TP, Einstein EB, Shine J, Picciotto MR, Wynick D, Zachariou V., Free PMC Article | 07/14/2012 |
| Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice | Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice.
Schauwecker PE., Free PMC Article | 07/9/2011 |
| Rotavirus infection of murine small intestine causes colonic secretion via age restricted galanin-1 receptor expression. | Rotavirus infection of murine small intestine causes colonic secretion via age restricted galanin-1 receptor expression.
Hempson SJ, Matkowskyj K, Bansal A, Tsao E, Habib I, Benya R, Mackow ER, Shaw RD. | 07/5/2010 |
| In GalR1KO mice, a high dose of galanin failed to induce any of the above effects, suggesting the pivotal role of GalR1 in decreased locomotor activity and stress-resistant effects caused by galanin i.c.v. injection studied here. | Bidirectional regulation of stress responses by galanin in mice: involvement of galanin receptor subtype 1.
Mitsukawa K, Lu X, Bartfai T., Free PMC Article | 01/21/2010 |
| The result indicate that galanin and its receptors (GalR1 and GalR2) might regulate neurite extension in differentiating neural stem cells and even participate in the development of the nervous system. | [Expression of galanin and galanin receptors in neurogenesis regions of adult mouse brain and effect of galanin on the neural stem cell's differentiation].
Ma J, Shan L, Yu LL, Yuan CG. | 01/21/2010 |
| differential expression of Galr1 may contribute to the differences in susceptibility to seizure-induced cell death between cell death-resistant and cell death-susceptible strains | Variation in Galr1 expression determines susceptibility to exocitotoxin-induced cell death in mice.
Kong S, Lorenzana A, Deng Q, McNeill TH, Schauwecker PE., Free PMC Article | 01/21/2010 |
| Galr1 receptors inhibit vagal afferent mechanosensitivity in the gastro-esophageal afferent preparation. | Involvement of galanin receptors 1 and 2 in the modulation of mouse vagal afferent mechanosensitivity.
Page AJ, Slattery JA, Brierley SM, Jacoby AS, Blackshaw LA., Free PMC Article | 01/21/2010 |
| GALR1 deficiency impaired adaptation to a 3-day high-fat diet challenge, leading to increased food intake, feed efficiency and weight gain. | Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge.
Zorrilla EP, Brennan M, Sabino V, Lu X, Bartfai T., Free PMC Article | 01/21/2010 |
| GalR1 knockout mice showed no difference with respect to acute nociception, but showed a modest tendency towards increased hyperalgesia after tissue injury and inflammation | Increased hyperalgesia after tissue injury and faster recovery of allodynia after nerve injury in the GalR1 knockout mice.
Malkmus S, Lu X, Bartfai T, Yaksh TL, Hua XY. | 01/21/2010 |
| mice lacking the GALR1 receptor (Galr1-/-) exhibited only slight increase in heat nociception in the hot plate, but not tail flick, test and showed no increase in spinal sensitization | Galanin and spinal nociceptive mechanisms: recent results from transgenic and knock-out models.
Wiesenfeld-Hallin Z, Xu XJ, Crawley JN, Hökfelt T. | 01/21/2010 |
| Homozygous Galr1-/- mice are viable, capable of breeding, and exhibit no significant difference in growth rate. They have reduced circulating levels of insulin-like growth factor-I (IGF-I) and exhibit spontaneous tonic-clonic seizures. | Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity.
Jacoby AS, Hort YJ, Constantinescu G, Shine J, Iismaa TP. | 01/21/2010 |
| Taken together, these findings provide strong evidence that Gal(1) is a heteroreceptor expressed on excitatory glutamatergic dorsal horn interneurons. | Galanin receptor 1 is expressed in a subpopulation of glutamatergic interneurons in the dorsal horn of the rat spinal cord.
Landry M, Bouali-Benazzouz R, André C, Shi TJ, Léger C, Nagy F, Hökfelt T. | 01/21/2010 |
| Knockout mice deficient in the GAL-R1 receptor subtype were normal on most memory tasks, while showing a small deficit in trace cued fear conditioning | Galanin impairs performance on learning and memory tasks: findings from galanin transgenic and GAL-R1 knockout mice.
Rustay NR, Wrenn CC, Kinney JW, Holmes A, Bailey KR, Sullivan TL, Harris AP, Long KC, Saavedra MC, Starosta G, Innerfield CE, Yang RJ, Dreiling JL, Crawley JN. | 01/21/2010 |
| Galanin receptor 1 knockout mice show increased anxiety-like behavior on the elevated plus-maze test, a finding that is consistent with the hypothesis that galanin exerts anxiolytic actions via the GAL-R1 receptor. | Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze.
Holmes A, Kinney JW, Wrenn CC, Li Q, Yang RJ, Ma L, Vishwanath J, Saavedra MC, Innerfield CE, Jacoby AS, Shine J, Iismaa TP, Crawley JN. | 01/21/2010 |
| Changes in levels of GalR1 may play an important role in modulating signaling events and neuroplasticity underlying physiological functions of the locus coeruleus. | GalR1, but not GalR2 or GalR3, levels are regulated by galanin signaling in the locus coeruleus through a cyclic AMP-dependent mechanism.
Hawes JJ, Brunzell DH, Wynick D, Zachariou V, Picciotto MR., Free PMC Article | 01/21/2010 |
| GalR1 mediate galanin protection from seizures and seizure-induced hippocampal injury in Li-pilocarpine and perforant-path- stimulation models of limbic status epilepticus, but not under conditions of kainic acid-induced seizures. | Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice.
Mazarati A, Lu X, Shinmei S, Badie-Mahdavi H, Bartfai T., Free PMC Article | 01/21/2010 |
| The duration of pain-like behaviours is significantly increased in mice lacking the galanin receptor 1 gene (Galr1-/-) after photochemically induced partial sciatic nerve ischemic injury. | Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors.
Blakeman KH, Hao JX, Xu XJ, Jacoby AS, Shine J, Crawley JN, Iismaa T, Wiesenfeld-Hallin Z. | 01/21/2010 |