| Mice harboring the T316N variant in the GABAAR gamma2 subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway. | Mice harboring the T316N variant in the GABA(A)R γ(2) subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway.
Jiang YL, Xia L, Zhao JJ, Zhou HM, Mi D, Wang X, Wang YY, Song CG, Jiang W. | 05/29/2024 |
| Increased GABA signaling in liver macrophage promotes HBV replication in HBV-carrier mice. | Increased GABA signaling in liver macrophage promotes HBV replication in HBV-carrier mice.
Chen Y, Yin Z, Zhang X, Zhao Y, Liu T, Lu WY, Wang S., Free PMC Article | 05/7/2024 |
| Microglial TNFalpha controls daily changes in synaptic GABAARs and sleep slow waves. | Microglial TNFα controls daily changes in synaptic GABAARs and sleep slow waves.
Pinto MJ, Bizien L, Fabre JMJ, Ðukanović N, Lepetz V, Henderson F, Pujol M, Sala RW, Tarpin T, Popa D, Triller A, Léna C, Fabre V, Bessis A., | 05/7/2024 |
| Neonatal inflammation via persistent TGF-beta1 downregulation decreases GABAAR expression in basolateral amygdala leading to the imbalance of the local excitation-inhibition circuits and anxiety-like phenotype in adult mice. | Neonatal inflammation via persistent TGF-β1 downregulation decreases GABA(A)R expression in basolateral amygdala leading to the imbalance of the local excitation-inhibition circuits and anxiety-like phenotype in adult mice.
Zhong H, Rong J, Yang Y, Liang M, Li Y, Zhou R. | 05/28/2022 |
| BDNF controls GABAAR trafficking and related cognitive processes via autophagic regulation of p62. | BDNF controls GABA(A)R trafficking and related cognitive processes via autophagic regulation of p62.
Tomoda T, Sumitomo A, Shukla R, Hirota-Tsuyada Y, Miyachi H, Oh H, French L, Sibille E., Free PMC Article | 03/5/2022 |
| Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model. | Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model.
Zhang CQ, Catron MA, Ding L, Hanna CM, Gallagher MJ, Macdonald RL, Zhou C., Free PMC Article | 01/8/2022 |
| Endoplasmic reticulum stress increases inflammatory cytokines in an epilepsy mouse model Gabrg2(+/Q390X) knockin: A link between genetic and acquired epilepsy? | Endoplasmic reticulum stress increases inflammatory cytokines in an epilepsy mouse model Gabrg2(+/Q390X) knockin: A link between genetic and acquired epilepsy?
Shen W, Poliquin S, Macdonald RL, Dong M, Kang JQ., Free PMC Article | 02/6/2021 |
| these data demonstrate the molecular basis for a comorbidity of epilepsy, anxiety, and suggest that impaired GABAA receptor function in CeA due to a loss-of-function mutation could at least contribute to anxiety | Molecular basis for and chemogenetic modulation of comorbidities in GABRG2-deficient epilepsies.
Zhang CQ, McMahon B, Dong H, Warner T, Shen W, Gallagher M, Macdonald RL, Kang JQ., Free PMC Article | 04/11/2020 |
| deletion of Gabrg2 on dopamine cells induced several behavioral traits associated with high risk of developing alcoholism. | Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABA(A) receptors on dopamine neurons in mice.
Stojakovic A, Walczak M, Cieślak PE, Trenk A, Sköld J, Zajdel J, Mirrasekhian E, Karlsson C, Thorsell A, Heilig M, Parkitna JR, Błasiak T, Engblom D., Free PMC Article | 02/9/2019 |
| This study found that the inactivation of gamma2-mediated synapses does not impact oligodendrocyte precursors proliferation and differentiation or the propensity of oligodendrocyte precursors to myelinate their presynaptic interneurons. | A specific GABAergic synapse onto oligodendrocyte precursors does not regulate cortical oligodendrogenesis.
Balia M, Benamer N, Angulo MC. | 05/19/2018 |
| The results of this study suggesting that mutations like GABRG2(Q390X) may alter brain thermal regulation and precipitate seizures during temperature elevations. | Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2(+/Q390X) mice.
Warner TA, Liu Z, Macdonald RL, Kang JQ., Free PMC Article | 02/3/2018 |
| GABAA receptor (GABAAR) and the Na(+)-K(+)-2Cl(-) cotransporter (NKCC1), but not the K(+)-Cl(-) cotransporter (KCC2), were expressed in the terminals of the CRH neurons at the median eminence (ME). In contrast, CRH neuronal somata were enriched with KCC2 but not with NKCC1. | A novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence.
Kakizawa K, Watanabe M, Mutoh H, Okawa Y, Yamashita M, Yanagawa Y, Itoi K, Suda T, Oki Y, Fukuda A., Free PMC Article | 07/29/2017 |
| This study demonstrated that the reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA gamma2 R43Q mouse model of absence epilepsy. | Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABA(A) γ2 R43Q mouse model of absence epilepsy.
Currie SP, Luz LL, Booker SA, Wyllie DJ, Kind PC, Daw MI., Free PMC Article | 07/1/2017 |
| Heterozygous Gabrg2(+/Q390X) KI mice are associated with a severe epileptic encephalopathy due to a dominant negative effect of the mutation, while heterozygous Gabrg2(+/-) KO mice are associated with mild absence epilepsy due to simple haploinsufficiency. | Differential molecular and behavioural alterations in mouse models of GABRG2 haploinsufficiency versus dominant negative mutations associated with human epilepsy.
Warner TA, Shen W, Huang X, Liu Z, Macdonald RL, Kang JQ., Free PMC Article | 06/24/2017 |
| This investigation demonstrates striking interfacial GABAA receptor subunit selectivity in the native milieu, suggesting that asymmetric occupancy of heteropentameric ion channels by alkylphenol-based anesthetics is sufficient to induce modulation of activity. | A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes.
Woll KA, Murlidaran S, Pinch BJ, Hénin J, Wang X, Salari R, Covarrubias M, Dailey WP, Brannigan G, Garcia BA, Eckenhoff RG., Free PMC Article | 05/20/2017 |
| This study describes a novel mechanism that regulates plasma receptor pools in the control of synaptic receptor density. | Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, Smart TG, Triller A, Kneussel M., Free PMC Article | 03/5/2016 |
| Neurotoxins from Snake Venoms and alpha-Conotoxin ImI Inhibit Functionally Active Ionotropic gamma-Aminobutyric Acid (GABA) Receptors | Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors.
Kudryavtsev DS, Shelukhina IV, Son LV, Ojomoko LO, Kryukova EV, Lyukmanova EN, Zhmak MN, Dolgikh DA, Ivanov IA, Kasheverov IE, Starkov VG, Ramerstorfer J, Sieghart W, Tsetlin VI, Utkin YN., Free PMC Article | 12/7/2015 |
| Study shows that the down-regulation of the gamma2 subunit of postsynaptic GABAARs in NG2 cells that accompanies the postnatal switch from synaptic to extrasynaptic GABAergic transmission between interneurons and these cells in the barrel cortex | Postnatal down-regulation of the GABAA receptor γ2 subunit in neocortical NG2 cells accompanies synaptic-to-extrasynaptic switch in the GABAergic transmission mode.
Balia M, Vélez-Fort M, Passlick S, Schäfer C, Audinat E, Steinhäuser C, Seifert G, Angulo MC. | 12/5/2015 |
| Dendritic spine abnormalities of Gabrg2+/- mice suggest association of functional defects in glutamatergic transmission with the established anxious-depressive phenotype of these mice | Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice.
Ren Z, Sahir N, Murakami S, Luellen BA, Earnheart JC, Lal R, Kim JY, Song H, Luscher B., Free PMC Article | 10/10/2015 |
| results suggest that the g2(R43Q) mutation significantly affects cortical microcircuitry in the cerebral cortex. | Cortical microarchitecture changes in genetic epilepsy.
Wimmer VC, Li MY, Berkovic SF, Petrou S. | 06/20/2015 |
| KIF21B participates in the delivery of GABAAR transport vesicles into dendrites. | The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors.
Labonté D, Thies E, Kneussel M. | 04/4/2015 |
| The gamma2 subunits (of GABA A receptors) cell surface levels were decreased by mutating each of the Beta2 subunit glycosylation sites. | Co-expression of γ2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor β2 subunits.
Lo WY, Lagrange AH, Hernandez CC, Gurba KN, Macdonald RL., Free PMC Article | 01/31/2015 |
| These results indicate that thalamic deltaGABAARs promote electrocortical signatures of deep NREM sleep, but do not mediate the effects of etomidate at the thalamus in vivo. | Thalamic δ-subunit containing GABAA receptors promote electrocortical signatures of deep non-REM sleep but do not mediate the effects of etomidate at the thalamus in vivo.
Mesbah-Oskui L, Orser BA, Horner RL., Free PMC Article | 01/10/2015 |
| The study demonstrates the molecular and functional diversity of the GABAAR system within the mouse colon providing a framework for developing GABAAR-based therapeutics in GI disorders. | Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
Seifi M, Brown JF, Mills J, Bhandari P, Belelli D, Lambert JJ, Rudolph U, Swinny JD., Free PMC Article | 10/4/2014 |
| The data of this study demonstrate the presence of IPSCs and the synaptic enrichment of the alpha1 and beta3 subunits and suggest that the gamma3 subunit is the most likely candidate for clustering GABAARs at synapses in the absence of the gamma2 subunit. | Synaptic GABAA receptor clustering without the γ2 subunit.
Kerti-Szigeti K, Nusser Z, Eyre MD., Free PMC Article | 10/4/2014 |