| The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis. | The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis.
Li N, Xu X, Liu D, Gao J, Gao Y, Wu X, Sheng H, Li Q, Mi J., Free PMC Article | 03/21/2023 |
| High ethanol preference and dissociated memory are co-occurring phenotypes associated with hippocampal GABAAR-delta receptor levels. | High ethanol preference and dissociated memory are co-occurring phenotypes associated with hippocampal GABA(A)R-δ receptor levels.
Jovasevic V, Radulovic J., Free PMC Article | 02/12/2022 |
| Cerebellum-Specific Deletion of the GABAA Receptor delta Subunit Leads to Sex-Specific Disruption of Behavior. | Cerebellum-Specific Deletion of the GABA(A) Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior.
Rudolph S, Guo C, Pashkovski SL, Osorno T, Gillis WF, Krauss JM, Nyitrai H, Flaquer I, El-Rifai M, Datta SR, Regehr WG., Free PMC Article | 05/8/2021 |
| Results suggest that GABAA([delta])R preferentially affects the anxiety-like behavior in open field test in a development-dependent manner, but only in female mice. | Gender-dependent regulation of anxiety-like behavior by δ subunit-containing GABAA receptor during postnatal development.
He Y, Zheng ZH, Zhou J, Hu P, Huang BW, Liu WZ, You WJ, Pan HQ, Pan BX, Zhang WH. | 04/4/2020 |
| Knockdown of Ttr in cultured cerebellar granule neurons significantly decreased the delta receptor expression; whereas overexpressing Ttr in cortical neurons increased the delta receptor expression. In vivo analysis of Ttr-/- mice revealed a significant decrease of the surface expression of the delta-GABAA-Rs in cerebellar granule neurons. Together, studies identified Ttr as a novel regulator of the delta-GABAA-Rs. | Identification of transthyretin as a novel interacting partner for the δ subunit of GABAA receptors.
Zhou L, Tang X, Li X, Bai Y, Buxbaum JN, Chen G., Free PMC Article | 10/5/2019 |
| Using mice with or without deletion of GABRD and protocols in which the conditioned tone stimuli were cross presented with different nonconditioned stimuli, study showed that when the 2 tone stimuli were largely similar, both genotypes froze similarly to either of them. However, when they differed markedly, the knockout mice froze much more than their wild-type littermates to the nonconditioned but not conditioned stimuli | δ Subunit-containing GABA(A) receptor prevents overgeneralization of fear in adult mice.
Zhang WH, Zhou J, Pan HQ, Wang XY, Liu WZ, Zhang JY, Yin XP, Pan BX., Free PMC Article | 04/14/2018 |
| findings suggest that GABAA(delta)R serves as a brake rather than a mediator of GABAergic inhibition in Lateral Amygdala. | Delta Subunit-Containing Gamma-Aminobutyric Acid A Receptor Disinhibits Lateral Amygdala and Facilitates Fear Expression in Mice.
Liu ZP, He QH, Pan HQ, Xu XB, Chen WB, He Y, Zhou J, Zhang WH, Zhang JY, Ying XP, Han RW, Li BM, Gao TM, Pan BX. | 03/3/2018 |
| Reduced GABAA R delta subunit expression and function in dentate gyrus granule cells is sufficient to induce deficits in learning and memory in mice. Findings suggest that the reduction in GABAA R delta subunit-mediated tonic inhibition in dentate gyrus granule cells contributes, at least in part, to deficits in learning and memory associated with chronic stress. | Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory.
Lee V, MacKenzie G, Hooper A, Maguire J., Free PMC Article | 01/13/2018 |
| These data suggest that pubertal synaptic pruning requires alpha4betadelta GABA-A receptors. | Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines.
Afroz S, Parato J, Shen H, Smith SS., Free PMC Article | 11/4/2017 |
| GABA A receptors delta subunit are necessary for synaptic plasticity in the CA3 field of hippocampus and for memory behavior. | δGABAA Receptors Are Necessary for Synaptic Plasticity in the Hippocampus: Implications for Memory Behavior.
Whissell PD, Avramescu S, Wang DS, Orser BA. | 07/1/2017 |
| This study demonstrated that Ectopic Expression of delta GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus. | Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
Tong X, Peng Z, Zhang N, Cetina Y, Huang CS, Wallner M, Otis TS, Houser CR., Free PMC Article | 04/23/2016 |
| Results show that delta-GABAARs expressed on parvalbumin interneurons modulate in vitro hippocampal gamma oscillations dynamics | In vitro gamma oscillations following partial and complete ablation of δ subunit-containing GABAA receptors from parvalbumin interneurons.
Ferando I, Mody I., Free PMC Article | 10/10/2015 |
| This study demonstrated that alpha6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells. | α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells.
Accardi MV, Brown PM, Miraucourt LS, Orser BA, Bowie D., Free PMC Article | 09/26/2015 |
| Gabrd subunits are expressed in the extrasynaptic cell membrane of interneurons in the dentate gyrus. | The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits α1, β2, and δ along their extrasynaptic cell membrane.
Milenkovic I, Vasiljevic M, Maurer D, Höger H, Klausberger T, Sieghart W. | 02/28/2015 |
| In an alpha4 subunit knockout mouse, a substantial decrease in delta subunit expression was seen in the ventrobasal nucleus of the thalamus. | Altered localization of the δ subunit of the GABAA receptor in the thalamus of α4 subunit knockout mice.
Peng Z, Zhang N, Chandra D, Homanics GE, Olsen RW, Houser CR., Free PMC Article | 01/31/2015 |
| The delta-GABAAR plays an important role in estrous cycle-mediated fluctuations in hippocampus-dependent learning and memory. | The role of the δ GABA(A) receptor in ovarian cycle-linked changes in hippocampus-dependent learning and memory.
Cushman JD, Moore MD, Olsen RW, Fanselow MS. | 01/31/2015 |
| Perimenstrual neurosteroid withdrawal is associated with upregulation of Gabrd receptors that mediate tonic inhibition in the dentate gyrus. | Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.
Carver CM, Wu X, Gangisetty O, Reddy DS., Free PMC Article | 01/24/2015 |
| results show the importance of the GABAAR d subunit in the regulation of CRH neurons, and the HPA axis, and demonstrate that dysregulation of CRH neurons alters stress-related behaviors. | Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors.
Lee V, Sarkar J, Maguire J., Free PMC Article | 01/10/2015 |
| This glutamate neuroplasticity was not observed in GABAA receptor delta-subunit-knockout (delta-KO) mice. | Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons.
Vashchinkina E, Manner AK, Vekovischeva O, den Hollander B, Uusi-Oukari M, Aitta-Aho T, Korpi ER., Free PMC Article | 09/13/2014 |
| The results of this study deltaGABAA receptors promote the performance of certain DG-dependent memory behaviors and facilitate neurogenesis. Furthermore, deltaGABAA receptors can be pharmacologically targeted to enhance these processes. | γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus.
Whissell PD, Rosenzweig S, Lecker I, Wang DS, Wojtowicz JM, Orser BA. | 01/25/2014 |
| Data suggest that estrous cycle-related regulation of neurosteroid-sensitive delta subunit-containing GABA(A) receptors mediates neuronal inhibition/plasticity and seizure susceptibility; delta subunit is upregulated in dentate gyrus during diestrus. | Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.
Wu X, Gangisetty O, Carver CM, Reddy DS., Free PMC Article | 08/31/2013 |
| GABAA delta-subunit-containing receptors are not required for enhancement of excitability and conduction velocity of cerebellar parallel fiber axons, since GABA facilitates both spike generation and propagation. | GABAA receptors increase excitability and conduction velocity of cerebellar parallel fiber axons.
Dellal SS, Luo R, Otis TS., Free PMC Article | 04/6/2013 |
| In both native and heterologous recombinant systems, murine delta subunit incorporation into GABARs leads to a dramatic increase in THIP sensitivity, a defining feature that accounts for the unique behavioral and neurophysiological properties of THIP. | Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors.
Meera P, Wallner M, Otis TS., Free PMC Article | 02/11/2012 |
| Data suggest that the availability of distinct GABA(A) R subtypes (Gabra2, -4, and Gabrd) provides a molecular mechanism endowing spatiotemporal specificity to GABAergic control of neuronal maturation in adult brain. | Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis.
Duveau V, Laustela S, Barth L, Gianolini F, Vogt KE, Keist R, Chandra D, Homanics GE, Rudolph U, Fritschy JM., Free PMC Article | 01/28/2012 |
| The results of this study suggested that deltaGABA(A)Rs in spinal neurons play a major physiological and pharmacological role in the regulation of acute nociception and central sensitization. | Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice.
Bonin RP, Labrakakis C, Eng DG, Whissell PD, De Koninck Y, Orser BA. | 09/24/2011 |