| Gabrb2 knock-out mice exhibit double-directed PMDD-like symptoms: GABAAR subunits, neurotransmitter metabolism disruption, and allopregnanolone binding. | Gabrb2 knock-out mice exhibit double-directed PMDD-like symptoms: GABAAR subunits, neurotransmitter metabolism disruption, and allopregnanolone binding.
Gao M, Zhang H, Sun Y, Gao Z, Sun C, Wei F, Gao D., Free PMC Article | 11/12/2022 |
| Protrudin modulates seizure activity through GABAA receptor regulation. | Protrudin modulates seizure activity through GABA(A) receptor regulation.
Lu X, Yang Y, Zhou R, Li Y, Yang Y, Wang X., Free PMC Article | 09/5/2020 |
| The results reveal that furin may regulate GABA-A receptors-mediated inhibitory synaptic transmission by altering the transcription of Gabrb2 and Gabrb3 subunits in epilepsy. | Transgenic overexpression of furin increases epileptic susceptibility.
Yang Y, He M, Tian X, Guo Y, Liu F, Li Y, Zhang H, Lu X, Xu D, Zhou R, Ma Y, Wang W, Chen G, Hu Y, Wang X., Free PMC Article | 12/14/2019 |
| In inhibitory transmission onto hippocampal CA1 pyramidal cells, deletion of all beta subunits 1, 2, and 3 completely eliminated inhibitory responses. In addition, only knockout of beta3, alone or in combination with another beta subunit, impaired inhibitory synaptic transmission. expression of beta3 alone on the background of the beta1-3 subunit knockout was sufficient to restore synaptic and extrasynaptic inhibitory ... | The GABA(A) Receptor β Subunit Is Required for Inhibitory Transmission.
Nguyen QA, Nicoll RA., Free PMC Article | 08/3/2019 |
| These extensive schizophrenia-like and comorbid phenotypes brought about by Gabrb2 knockout, in conjunction with our previous findings on GABRB2 association with schizophrenia, support a pivotal role of GABRB2 in schizophrenia etiology. | Gabrb2-knockout mice displayed schizophrenia-like and comorbid phenotypes with interneuron-astrocyte-microglia dysregulation.
Yeung RK, Xiang ZH, Tsang SY, Li R, Ho TYC, Li Q, Hui CK, Sham PC, Qiao MQ, Xue H., Free PMC Article | 02/9/2019 |
| Rebound potentiation is an input-specific plasticity that occurs only at basket cell-Purkinje cell inhibitory synapses and critically relies on GABAA receptors containing the beta2-subunit. | Interneuron- and GABA(A) receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells.
He Q, Duguid I, Clark B, Panzanelli P, Patel B, Thomas P, Fritschy JM, Smart TG., Free PMC Article | 04/16/2016 |
| Gabrb2 receptor subunits are expressed in interneurons of the dentate gyrus along with alpha1 and delta subunits. | The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits α1, β2, and δ along their extrasynaptic cell membrane.
Milenkovic I, Vasiljevic M, Maurer D, Höger H, Klausberger T, Sieghart W. | 02/28/2015 |
| The gamma2 subunits (of GABA A receptors) interacted with Beta2 subunit N-glycans and subdomains containing the glycosylation sites. | Co-expression of γ2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor β2 subunits.
Lo WY, Lagrange AH, Hernandez CC, Gurba KN, Macdonald RL., Free PMC Article | 01/31/2015 |
| In an epileptic stargazer mouse model, Gabrb2 receptor subunit expression in the ventral thalamus is increased. | Altered thalamic GABAA-receptor subunit expression in the stargazer mouse model of absence epilepsy.
Seo S, Leitch B. | 04/12/2014 |
| These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops. | Direct binding of GABAA receptor β2 and β3 subunits to gephyrin.
Kowalczyk S, Winkelmann A, Smolinsky B, Förstera B, Neundorf I, Schwarz G, Meier JC. | 11/16/2013 |
| Data indicate that the expression levels of [beta]2/3 GABAAR showed 2.81 +/- 0.08-fold and 3.83 +/- 0.07-fold increases, respectively, in the pancreatectomized mice 3 and 14 days after surgery. | β-cell proliferation is associated with increased A-type γ-aminobutyric acid receptor expression in pancreatectomized mice.
Wang Z, Purwana I, Zhao F, Zhao X, Chan K, He L, Soukhov E, Korytnikov R, Li X, Wang Q. | 08/31/2013 |
| Different NMDA-receptor subunit 1 and GABA(B)-receptor subunit 2 levels observed in naive mouse strains reflect strain-dependent expression of subunits and are proposed to lead to altered stoichiometry of GABA(B)-receptor complexes. | Strain-dependent hippocampal protein levels of GABA(B)-receptor subunit 2 and NMDA-receptor subunit 1.
Sunyer B, An G, Kang SU, Höger H, Lubec G. | 01/21/2010 |
| Deletion of the beta(2) subunit had no effect on the diazepam-induced current and therefore these extrasynaptic receptors do not contain this subunit. | The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.
Herd MB, Haythornthwaite AR, Rosahl TW, Wafford KA, Homanics GE, Lambert JJ, Belelli D., Free PMC Article | 01/21/2010 |
| Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling. | Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling.
Ives JH, Drewery DL, Thompson CL. | 01/21/2010 |
| deletion of beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs | Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs.
Blednov YA, Jung S, Alva H, Wallace D, Rosahl T, Whiting PJ, Harris RA. | 01/21/2010 |
| GABA(A) receptors interact directly with ethylmaleimide sensitive factor, a critical regulator of vesicular dependent protein trafficking. | Direct interaction of N-ethylmaleimide-sensitive factor with GABA(A) receptor beta subunits.
Goto H, Terunuma M, Kanematsu T, Misumi Y, Moss SJ, Hirata M. | 01/21/2010 |
| a conserved lysine in the TM2-3 of alpha1, beta2, and gamma2 of the GABA-A receptor has an asymmetric function in different GABAA subunits | An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits.
Hales TG, Deeb TZ, Tang H, Bollan KA, King DP, Johnson SJ, Connolly CN. | 01/21/2010 |
| Results describe an up-regulation in the tyrosine kinase phosphorylation of GABA(A )receptor beta(2)- and gamma(2)-subunits following chronic ethanol exposure, but no effect on alpha(1)-subunit in mouse cultured cortical neurons. | Tyrosine kinase phosphorylation of GABA(A) receptor alpha1, beta2 and gamma2 subunits following chronic intermittent ethanol (CIE) exposure of cultured cortical neurons of mice.
Ravindran CR, Ticku MK. | 01/21/2010 |