| Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis. | Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis.
Nam DE, Park SJ, Omole S, Um E, Hakami RM, Hahn YS., Free PMC Article | 07/18/2024 |
| Gab1 Overexpression Attenuates Susceptibility to Ventricular Arrhythmias in Pressure Overloaded Heart Failure Mouse Hearts. | Gab1 Overexpression Attenuates Susceptibility to Ventricular Arrhythmias in Pressure Overloaded Heart Failure Mouse Hearts.
Liu M, Zhao J, Lu Y, Chen Z, Feng X, Pan G. | 03/25/2024 |
| Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation. | Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation.
Xu J, Li S, Jin W, Zhou H, Zhong T, Cheng X, Fu Y, Xiao P, Cheng H, Wang D, Ke Y, Jiang Z, Zhang X., Free PMC Article | 03/27/2023 |
| Gab1 Overexpression Alleviates Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis Through PI3K/Akt Signaling Pathway. | Gab1 Overexpression Alleviates Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis Through PI3K/Akt Signaling Pathway.
Zhang Z, Shen C, Wu N, Wang J, Du W, Chen X. | 12/17/2022 |
| GAB1 is upregulated to promote anaplastic thyroid cancer cell migration through AKT-MDR1. | GAB1 is upregulated to promote anaplastic thyroid cancer cell migration through AKT-MDR1.
Song P, Xu H, He Y, Sun J, Xu Z, Huang P, Ge M, Zhang X, Ke Y, Cheng H. | 05/7/2022 |
| GAB1 alleviates septic lung injury by inhibiting the TLR4/ NF-kappaB pathway. | GAB1 alleviates septic lung injury by inhibiting the TLR4/ NF-κB pathway.
Sun L, Zhu H, Zhang K. | 04/2/2022 |
| Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis. | Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis.
Mizutani N, Hikita H, Saito Y, Myojin Y, Sato K, Urabe M, Kurahashi T, Shiode Y, Sakane S, Murai K, Nozaki Y, Kodama T, Sakamori R, Yoshida Y, Tatsumi T, Takehara T. | 07/31/2021 |
| S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygenglucose deprivation and reoxygenation by upregulating GAB1 expression. | S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen‑glucose deprivation and reoxygenation by upregulating GAB1 expression.
Hu W, Lin C., Free PMC Article | 04/17/2021 |
| Increased expression of GAB1 promotes inflammation and fibrosis in systemic sclerosis. | Increased expression of GAB1 promotes inflammation and fibrosis in systemic sclerosis.
Shi X, Liu Q, Zhao H, Lu J, Huang Y, Ma Y, Xia J, Liu M, Tu W, Jin L, Wang J, Zhao Y, Wu W. | 10/31/2020 |
| Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination. | Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination.
Zhou L, Shao CY, Xie YJ, Wang N, Xu SM, Luo BY, Wu ZY, Ke YH, Qiu M, Shen Y., Free PMC Article | 10/24/2020 |
| Gab1 enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner | The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner.
Bongartz H, Gille K, Hessenkemper W, Mandel K, Lewitzky M, Feller SM, Schaper F., Free PMC Article | 07/18/2020 |
| Results found that GAB1 expression is downregulated in both lung tissues and mouse alveolar epithelial cells (MLE-12) following bronchopulmonary dysplasia modeling. GAB1 was a direct target gene of miR-29a. | Inhibition of microRNA-29a alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice via upregulation of GAB1.
Hu Y, Xie L, Yu J, Fu H, Zhou D, Liu H., Free PMC Article | 06/20/2020 |
| The results of this study suggested that Gab1 plays an important role in the pathophysiology of AD and may represent a novel therapeutic target for diseases involving cholinergic dysfunction. | Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function.
Lu NN, Tan C, Sun NH, Shao LX, Liu XX, Gao YP, Tao RR, Jiang Q, Wang CK, Huang JY, Zhao K, Wang GF, Liu ZR, Fukunaga K, Lu YM, Han F., Free PMC Article | 10/12/2019 |
| Conditional Gab1 knockout mice showed general retardation in muscular growth and hypotrophy of extrafusal muscle fibers. Muscle-specific Gab1 knockout mutant exhibited significant underdevelopment of muscle spindles, which are normally regulated by NRG1, and abnormal proprioceptive behavior. Selective knockdown of Gab1 in C2C12 muscle cells reduced NRG1-induced expression of Egr3. | Grb2-associated binder-1 is required for extrafusal and intrafusal muscle fiber development.
Park SY, Jang SY, Shin YK, Yoon BA, Lee HJ, Park HT. | 03/24/2018 |
| Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r, synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r = interleukin-4 receptor) | Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.
Guo X, Li T, Xu Y, Xu X, Zhu Z, Zhang Y, Xu J, Xu K, Cheng H, Zhang X, Ke Y., Free PMC Article | 09/16/2017 |
| these findings suggest that the striated muscle-specific high-MW isoform of Gab1 has a crucial role for NRG-1/ErbB signaling in cardiomyocytes. | Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes.
Yasui T, Masaki T, Arita Y, Ishibashi T, Inagaki T, Okazawa M, Oka T, Shioyama W, Yamauchi-Takihara K, Komuro I, Sakata Y, Nakaoka Y., Free PMC Article | 07/1/2017 |
| These findings provide the direct evidence about the roles of docking protein Gab1 in lungs. | Epithelial disruption of Gab1 perturbs surfactant homeostasis and predisposes mice to lung injuries.
Wang K, Qin S, Liang Z, Zhang Y, Xu Y, Chen A, Guo X, Cheng H, Zhang X, Ke Y. | 06/24/2017 |
| These results demonstrate that cardiomyocyte Gab1 is a critical regulator of the compensatory cardiac response to aging and hemodynamic stress. | Cardiac Gab1 deletion leads to dilated cardiomyopathy associated with mitochondrial damage and cardiomyocyte apoptosis.
Zhao J, Yin M, Deng H, Jin FQ, Xu S, Lu Y, Mastrangelo MA, Luo H, Jin ZG., Free PMC Article | 12/17/2016 |
| Gab1 is essential regulator of the hair cycle and the self-renewal of hair follicle stem cells. | Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence.
Akilli Öztürk Ö, Pakula H, Chmielowiec J, Qi J, Stein S, Lan L, Sasaki Y, Rajewsky K, Birchmeier W. | 08/6/2016 |
| Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo. | Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1.
Li X, Wang D, Chen Z, Lu E, Wang Z, Duan J, Tian W, Wang Y, You L, Zou Y, Cheng Y, Zhu Q, Wan X, Xi T, Jiang M, Han Y, Cao C, Birnbaumer L, Chu WM, Yang Y., Free PMC Article | 07/25/2015 |
| Hepatocyte Gab1 is required for liver fibrosis and that hepatocyte CCL5 could be an important contributor to this process. | Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice.
Kizu T, Yoshida Y, Furuta K, Ogura S, Egawa M, Chatani N, Hamano M, Takemura T, Ezaki H, Kamada Y, Nishida K, Nakaoka Y, Kiso S, Takehara T. | 06/6/2015 |
| endothelial Gab1 signaling inhibited splenomegaly in portal hypertension independent of angiogenesis. | Endothelial Gab1 deficiency aggravates splenomegaly in portal hypertension independent of angiogenesis.
Jiang B, Deng Q, Huo Y, Li W, Shibuya M, Luo J. | 05/2/2015 |
| Suggest that Gab1 is essential for cardioprotection against ischemia reperfusion oxidative injury, mediating survival signaling. | Grb2-associated binder 1 is essential for cardioprotection against ischemia/reperfusion injury.
Sun L, Chen C, Jiang B, Li Y, Deng Q, Sun M, An X, Yang X, Yang Y, Zhang R, Lu Y, Zhu DS, Huo Y, Feng GS, Zhang Y, Luo J. | 01/3/2015 |
| These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development | Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development.
Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X., Free PMC Article | 09/20/2014 |
| the acquired substrate preference for GAB1 is critical for the ERBB2 mutant-induced oncogenesis. | Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants.
Fan YX, Wong L, Marino MP, Ou W, Shen Y, Wu WJ, Wong KK, Reiser J, Johnson GR., Free PMC Article | 08/31/2013 |