| FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis. | FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis.
Lu J, Ling X, Sun Y, Liu L, Liu L, Wang X, Lu C, Ren C, Han X, Yu Z. | 07/13/2023 |
| Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II. | Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II.
Serna E, Mauricio MD, San-Miguel T, Guerra-Ojeda S, Verdú D, Valls A, Arc-Chagnaud C, De la Rosa A, Viña J., Free PMC Article | 03/22/2023 |
| G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation. | G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation.
Hashimoto R, Gupte SA. | 06/25/2022 |
| Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function. | Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function.
Sohn JH, Ji Y, Cho CY, Nahmgoong H, Lim S, Jeon YG, Han SM, Han JS, Park I, Rhee HW, Kim S, Kim JB. | 01/8/2022 |
| Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life. | Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life.
De la Rosa A, Gomez-Cabrera MC, Vinue A, Gonzalez-Navarro H, Sanchez-Andres JV, Viña J. | 07/17/2021 |
| Glucose-6-phosphate dehydrogenase deficiency contributes to metabolic abnormality and pulmonary hypertension. | Glucose-6-phosphate dehydrogenase deficiency contributes to metabolic abnormality and pulmonary hypertension.
Varghese MV, James J, Rafikova O, Rafikov R., Free PMC Article | 05/15/2021 |
| G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases. | G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.
Dhagia V, Kitagawa A, Jacob C, Zheng C, D'Alessandro A, Edwards JG, Rocic P, Gupte R, Gupte SA., Free PMC Article | 03/28/2021 |
| These results demonstrated that the miR-206-G6PD pathway suppresses muscle cell proliferation, and these findings may facilitate the treatment of muscle diseases. | MicroRNA-206 regulates cell proliferation by targeting G6PD in skeletal muscle.
Jiang A, Dong C, Li B, Zhang Z, Chen Y, Ning C, Wu W, Liu H. | 06/27/2020 |
| High glucose induces ubiquitination of G6PD by VHL E3 ubiquitin ligase, which leads to ROS accumulation and podocyte injury. | High glucose-induced ubiquitination of G6PD leads to the injury of podocytes.
Wang M, Hu J, Yan L, Yang Y, He M, Wu M, Li Q, Gong W, Yang Y, Wang Y, Handy DE, Lu B, Hao C, Wang Q, Li Y, Hu R, Stanton RC, Zhang Z. | 05/23/2020 |
| this study shows that G6PD activity can modulate macrophage response to Leishmania major infection | Glucose-6-phosphate dehydrogenase (G6PD) activity can modulate macrophage response to Leishmania major infection.
Zamani S, Hoseini AZ, Namin AM. | 07/20/2019 |
| G6PD protects ischemic brain injury through increasing pentose phosphate pathway. | G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway.
Cao L, Zhang D, Chen J, Qin YY, Sheng R, Feng X, Chen Z, Ding Y, Li M, Qin ZH. | 06/2/2018 |
| Hepatic transcriptional profiling response to fava bean-induced oxidative stress in glucose-6-phosphate dehydrogenase-deficient mice has been reported. | Hepatic transcriptional profiling response to fava bean-induced oxidative stress in glucose-6-phosphate dehydrogenase-deficient mice.
Du G, Xiao M, Wei X, Zhou C, Li S, Cai W. | 03/24/2018 |
| ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia that can be successfully reversed. | ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J., Free PMC Article | 02/3/2018 |
| 20-HETE elicited mitochondrial superoxide production and promoted secretory phenotype of vascular smooth muscle cells by activating MAPK1-Elk-1, all of which are blocked by inhibition of G6PD. | 20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition.
Lakhkar A, Dhagia V, Joshi SR, Gotlinger K, Patel D, Sun D, Wolin MS, Schwartzman ML, Gupte SA., Free PMC Article | 07/1/2017 |
| yeast hydrolysate supplementation suppressed body fat accumulation by attenuating fatty acid synthesis through the downregulation of hepatic G6PD and malic enzyme activities. | Effects of yeast hydrolysate on hepatic lipid metabolism in high-fat-diet-induced obese mice: yeast hydrolysate suppresses body fat accumulation by attenuating fatty acid synthesis.
Jung EY, Hong YH, Kim JH, Park Y, Bae SH, Chang UJ, Suh HJ. | 07/27/2013 |
| Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver | Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver.
Walsh CM, Suchanek AL, Cyphert TJ, Kohan AB, Szeszel-Fedorowicz W, Salati LM., Free PMC Article | 04/6/2013 |
| F2 homozygous Gpdx mutant with C57L/J background exhibited the G6PD activity of 0.9+/-0.1 U/g Hb, level similar to those of G6PD deficiency in human. | Development of a novel mouse model of severe glucose-6-phosphate dehydrogenase (G6PD)-deficiency for in vitro and in vivo assessment of hemolytic toxicity to red blood cells.
Ko CH, Li K, Li CL, Ng PC, Fung KP, James AE, Wong RP, Gu GJ, Fok TF. | 02/25/2012 |
| Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4 | Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4.
Spencer NY, Yan Z, Boudreau RL, Zhang Y, Luo M, Li Q, Tian X, Shah AM, Davisson RL, Davidson B, Banfi B, Engelhardt JF., Free PMC Article | 05/21/2011 |
| as compared with control mice, G6PD-deficient mice had increased oxidative stress, as manifested by decreased NADPH levels and decreased GSH levels, and increased markers of lipid peroxidation. | Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria.
Xu Y, Zhang Z, Hu J, Stillman IE, Leopold JA, Handy DE, Loscalzo J, Stanton RC., Free PMC Article | 03/1/2010 |
| The study findings demonstrate a novel association between G6PD-status and inducibility of CYP2A5 and indicate that oxidative stress is not likely the key regulator of CYP2A5 expression. | Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.
Nichols KD, Kirby GM. | 01/21/2010 |
| G6PD is required for limiting oxidative mutagenesis in the mouse spleen; Gpdx(a-m2Neu) is the first hypomorphic allele of a mouse housekeeping gene associated with elevated somatic mutagenesis in vivo | Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase.
Felix K, Rockwood LD, Pretsch W, Bornkamm GW, Janz S. | 01/21/2010 |
| G6PD is an essential myocardial antioxidant enzyme, required for maintaining cellular glutathione levels and protecting against oxidative stress-induced cardiac dysfunction during ischemia-reperfusion. | Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase.
Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R. | 01/21/2010 |
| not indispensable for early embryo development; severe deficiency in the extraembryonic tissues impairs development of the placenta and causes death of the embryo; is indispensable for survival when the embryo is exposed to oxygen through its blood supply | Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal.
Longo L, Vanegas OC, Patel M, Rosti V, Li H, Waka J, Merghoub T, Pandolfi PP, Notaro R, Manova K, Luzzatto L., Free PMC Article | 01/21/2010 |
| G6PD proves indispensable for definitive erythropoiesis. | G6PD is indispensable for erythropoiesis after the embryonic-adult hemoglobin switch.
Paglialunga F, Fico A, Iaccarino I, Notaro R, Luzzatto L, Martini G, Filosa S. | 01/21/2010 |