| miR-199b-5p enhances the proliferation of medullary thymic epithelial cells via regulating Wnt signaling by targeting Fzd6. | miR-199b-5p enhances the proliferation of medullary thymic epithelial cells via regulating Wnt signaling by targeting Fzd6.
Wang X, Li Y, Gong B, Zhang K, Ma Y, Li Y. | 06/19/2021 |
| Mesenchymal stem cell-derived extracellular vesicles suppress the fibroblast proliferation by downregulating FZD6 expression in fibroblasts via micrRNA-29b-3p in idiopathic pulmonary fibrosis. | Mesenchymal stem cell-derived extracellular vesicles suppress the fibroblast proliferation by downregulating FZD6 expression in fibroblasts via micrRNA-29b-3p in idiopathic pulmonary fibrosis.
Wan X, Chen S, Fang Y, Zuo W, Cui J, Xie S. | 03/20/2021 |
| We demonstrate using mice that Fzd3 and Fzd6 similarly regulate axon turning, are functionally redundant with each other, and that Fzd3 genetically interacts with Vangl2 to guide this process | Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons.
Ghimire SR, Deans MR., Free PMC Article | 07/4/2020 |
| Fzd3 and Fzd6 play a redundant role in controlling the polarity of developing skin, but through non-identical mechanisms. | Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.
Dong B, Vold S, Olvera-Jaramillo C, Chang H., Free PMC Article | 02/16/2019 |
| Fzd4 and Fzd6 genes have a deep patterning effect on arterial vessel morphogenesis that may determine its functional efficiency | Planar cell polarity genes frizzled4 and frizzled6 exert patterning influence on arterial vessel morphogenesis.
Markovič R, Peltan J, Gosak M, Horvat D, Žalik B, Seguy B, Chauvel R, Malandain G, Couffinhal T, Duplàa C, Marhl M, Roux E., Free PMC Article | 08/26/2017 |
| Eliminating Fz6 in most hair follicle cells or in the inter-follicular epidermis at E15.5 suggests that planar cell polarity signaling in developing follicles is not required to maintain their orientation. | The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation.
Chang H, Smallwood PM, Williams J, Nathans J., Free PMC Article | 05/28/2016 |
| Data show that Wnt receptor, Frizzled-6 (Fzd6) -/- hematopoietic stem/progenitor cell (HSPC) exhibit poor emergency hematopoiesis. | Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal.
Abidin BM, Owusu Kwarteng E, Heinonen KM. | 12/19/2015 |
| Fz3 and Fz6 have partly interchangeable roles in tissue polarity signaling for epithelial orientation and axon growth and guidance | Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.
Hua ZL, Chang H, Wang Y, Smallwood PM, Nathans J., Free PMC Article | 12/20/2014 |
| This study confirms our speculation that down-regulation of FZD6 by beta-Carotene is causally related to the observed up-regulation of cancer related genes | Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung.
Piga R, van Dartel D, Bunschoten A, van der Stelt I, Keijer J. | 06/28/2014 |
| Fzd6-mediated Wnt signaling likely regulates the overall differentiation process of nail/claw formation. | Frizzled6 deficiency disrupts the differentiation process of nail development.
Cui CY, Klar J, Georgii-Heming P, Fröjmark AS, Baig SM, Schlessinger D, Dahl N., Free PMC Article | 10/19/2013 |
| Our results support a role of miR-194 in liver tumorigenesis through its endogenous target Fzd6. | MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6.
Krützfeldt J, Rösch N, Hausser J, Manoharan M, Zavolan M, Stoffel M. | 02/18/2012 |
| FZD6 mutations can result in severe defects in nail and claw formation through reduced or abolished membranous FZD(6) levels and several nonfunctional WNT-FZD pathways. | Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia.
Fröjmark AS, Schuster J, Sobol M, Entesarian M, Kilander MBC, Gabrikova D, Nawaz S, Baig SM, Schulte G, Klar J, Dahl N., Free PMC Article | 08/20/2011 |
| The time course of local hair follicle refinement and the resulting evolution of a montage of competing patterns in Fz6(-/-) skin, is defined. | When whorls collide: the development of hair patterns in frizzled 6 mutant mice.
Wang Y, Chang H, Nathans J., Free PMC Article | 01/1/2011 |
| Downregulated by dietary beta-carotene in lungs of knockout Bcmo1-deficient mice. | Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice.
van Helden YG, Godschalk RW, Heil SG, Bunschoten A, Hessel S, Amengual J, Bonet ML, von Lintig J, van Schooten FJ, Keijer J. | 09/20/2010 |
| Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect. | Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect.
Stuebner S, Faus-Kessler T, Fischer T, Wurst W, Prakash N. | 04/12/2010 |
| Elimination of Fzd6 expression by crossing into Fzd6(-/-) mice significantly delays development of chronic lymphocytic leukemia in this model. | Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemia.
Wu QL, Zierold C, Ranheim EA., Free PMC Article | 01/21/2010 |
| Fz6 is expressed in the skin and hair follicles, and targeted deletion of the Fz6 gene produces stereotyped whorls on the hind feet, variable whorls and tufts on the head, and misorientation of hairs on the torso. | Frizzled6 controls hair patterning in mice.
Guo N, Hawkins C, Nathans J., Free PMC Article | 01/21/2010 |
| In the inner ear of a Vangl2 mutant (Looptail; Lp), Fz3 and Fz6 proteins accumulate to normal levels but do not localize correctly at the cell surface. | The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells.
Wang Y, Guo N, Nathans J., Free PMC Article | 01/21/2010 |