DDX27 regulates oral squamous cell carcinoma development through targeting CSE1L. | DDX27 regulates oral squamous cell carcinoma development through targeting CSE1L. Li G, Li R, Wang W, Sun M, Wang X. | 02/20/2024 |
Mechanism of exportin retention in the cell nucleus. | Mechanism of exportin retention in the cell nucleus. Kapinos LE, Kalita J, Kassianidou E, Rencurel C, Lim RYH., Free PMC Article | 02/6/2024 |
The role of CSE1L silencing in the regulation of proliferation and apoptosis via the AMPK/mTOR signaling pathway in chronic myeloid leukemia. | The role of CSE1L silencing in the regulation of proliferation and apoptosis via the AMPK/mTOR signaling pathway in chronic myeloid leukemia. Liu XY, Wang YH, Wang J, Quan JK, Li XD, Guan KP. | 01/28/2023 |
[Expression and Clinical Significance of CAS in Acute Myeloid Leukemia Patients]. | [Expression and Clinical Significance of CAS in Acute Myeloid Leukemia Patients]. Guo HR, Wang X, Zhang H, Guan KP. | 06/18/2022 |
Butyrate supplementation regulates expression of chromosome segregation 1like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer. | Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer. Chang CC, Kao WY, Liu CY, Su HH, Kan YA, Lin PY, Ku WC, Chang KW, Yang RN, Huang CJ., Free PMC Article | 04/30/2022 |
PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer. | PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer. Salvi A, Young AN, Huntsman AC, Pergande MR, Korkmaz MA, Rathnayake RA, Mize BK, Kinghorn AD, Zhang X, Ratia K, Schirle M, Thomas JR, Brittain SM, Shelton C, Aldrich LN, Cologna SM, Fuchs JR, Burdette JE., Free PMC Article | 03/26/2022 |
The microRNA-451a/chromosome segregation 1-like axis suppresses cell proliferation, migration, and invasion and induces apoptosis in nasopharyngeal carcinoma. | The microRNA-451a/chromosome segregation 1-like axis suppresses cell proliferation, migration, and invasion and induces apoptosis in nasopharyngeal carcinoma. Luo Y, Qu X, Kan D, Cai B., Free PMC Article | 01/1/2022 |
CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. | CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y., Free PMC Article | 08/28/2021 |
Functional regulation of human trophoblast cells by CSE1L. | Functional regulation of human trophoblast cells by CSE1L. Zhou Y, Zhou Q, Li L, Gu Y, Sun X, Wang S, Wang X. | 06/26/2021 |
CSE1L promotes proliferation and migration in oral cancer through positively regulating MITF. | CSE1L promotes proliferation and migration in oral cancer through positively regulating MITF. Wang YS, Peng C, Guo Y, Li Y. | 04/3/2021 |
Cellular apoptosis susceptibility protein (CAS) suppresses the proliferation of breast cancer cells by upregulated cyp24a1. | Cellular apoptosis susceptibility protein (CAS) suppresses the proliferation of breast cancer cells by upregulated cyp24a1. Ye M, Han R, Shi J, Wang X, Zhao AZ, Li F, Chen H. | 11/21/2020 |
These findings show changes in CAS/CSE1L during Barrett's esophagus progression. CAS/CSE1L may represent a potential marker for dysplasia/carcinoma. | Expression of CAS/CSE1L, the Cellular Apoptosis Susceptibility Protein, Correlates With Neoplastic Progression in Barrett's Esophagus. Jiang K, Neill K, Cowden D, Klapman J, Eschrich S, Pimiento J, Malafa MP, Coppola D., Free PMC Article | 08/10/2019 |
CSE1L was significantly enriched in the seminoma tissue compared with the non-tumour normal testis tissue. CSE1L also co-localized with alpha-tubulin in the cells with a potential to divide. In the seminoma cell line TCam-2, CSE1L was associated with the spindles and the centrosomes during cell division. | CSE1L participates in regulating cell mitosis in human seminoma. Liu C, Wei J, Xu K, Sun X, Zhang H, Xiong C., Free PMC Article | 04/20/2019 |
CSE1L expression was correlated with MSH6 expression in tumor samples and was associated with poor prognosis in patients with osteosarcoma. Taken together, our results demonstrate that the CSE1L-MSH6 axis has an important role in osteosarcoma progression. | CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival. Cheng DD, Lin HC, Li SJ, Yao M, Yang QC, Fan CY., Free PMC Article | 11/17/2018 |
CSE1L appears to be critical for the nuclear import of certain key repressive proteins. Indeed, NOVA1, HDAC1, HDAC2, and HDAC8, genes known as silencing factors, became delocalized into cytosol upon CSE1L depletion. | Roles of the CSE1L-mediated nuclear import pathway in epigenetic silencing. Dong Q, Li X, Wang CZ, Xu S, Yuan G, Shao W, Liu B, Zheng Y, Wang H, Lei X, Zhang Z, Zhu B., Free PMC Article | 08/18/2018 |
The combination of CTNB1, XPO2, and CAPG achieved 95% sensitivity and 96% specificity for the discrimination of these subtypes. We developed two uterine aspirate-based signatures to diagnose Endometrial cancer and classify tumors in the most prevalent histologic subtypes. This will improve diagnosis and assist in the prediction of the optimal surgical treatment | Targeted Proteomics Identifies Proteomic Signatures in Liquid Biopsies of the Endometrium to Diagnose Endometrial Cancer and Assist in the Prediction of the Optimal Surgical Treatment. Martinez-Garcia E, Lesur A, Devis L, Cabrera S, Matias-Guiu X, Hirschfeld M, Asberger J, van Oostrum J, Casares de Cal MLÁ, Gómez-Tato A, Reventos J, Domon B, Colas E, Gil-Moreno A. | 07/28/2018 |
Our data suggest a previously unanticipated link between CAS and integrin beta1 signaling which correlates with an aggressive hepatocellular carcinoma phenotype. | Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC). Winkler J, Roessler S, Sticht C, DiGuilio AL, Drucker E, Holzer K, Eiteneuer E, Herpel E, Breuhahn K, Gretz N, Schirmacher P, Ori A, Singer S., Free PMC Article | 12/16/2017 |
CSE1L knockdown by shRNA inhibited protein, resulting in decreased cell proliferation, reduced colony formation in soft agar, and induction of apoptosis. CSE1L protein is expressed early and across all stages of colorectal carcinoma (CRC) development. shRNA knockdown of CSE1L was associated with inhibition of tumorigenesis in CRC cells. CSE1L may represent a potential target for treatment of CRC. | Knockdown of CSE1L Gene in Colorectal Cancer Reduces Tumorigenesis in Vitro. Pimiento JM, Neill KG, Henderson-Jackson E, Eschrich SA, Chen DT, Husain K, Shibata D, Coppola D, Malafa MP., Free PMC Article | 10/14/2017 |
Data suggest that CAS overexpression in thyroid carcinoma depends on the subtype and the disease stage. Our findings also indicate that CAS maintains papillary thyroid cell proliferation and survival. | Cellular apoptosis susceptibility (CAS) is overexpressed in thyroid carcinoma and maintains tumor cell growth: A potential link to the BRAFV600E mutation. Holzer K, Drucker E, Oliver S, Winkler J, Eiteneuer E, Herpel E, Breuhahn K, Singer S. | 12/31/2016 |
There is a relationship between nuclear CSE1L overexpression and distant metastasis in breast cancer. | Does CSE1L Overexpression Affect Distant Metastasis Development in Breast Cancer? Yuksel UM, Turker I, Dilek G, Dogan L, Gulcelik MA, Oksuzoglu B. | 07/16/2016 |
CAS plays contrasting roles in proliferation and apoptosis | The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation. Monian P, Jiang X., Free PMC Article | 06/28/2016 |
hCAS/CSE1L is responsible for controlling the homologous recombinational repair activity by directly interacting with RAD51. | hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair. Okimoto S, Sun J, Fukuto A, Horikoshi Y, Matsuda S, Matsuda T, Ikura M, Ikura T, Machida S, Kurumizaka H, Miyamoto Y, Oka M, Yoneda Y, Kiuchi Y, Tashiro S. | 05/14/2016 |
nuclear CSE1L is mainly non-phosphorylated CSE1L and is involved in gene regulation and cytoplasmic CSE1L is mainly phosphorylated CSE1L and is involved in cytoplasmic signaling regulation in melanocytic tumorigenesis. | High expression of cytoplasmic phosphorylated CSE1L in malignant melanoma but not in benign nevi: phosphorylated CSE1L for the discrimination between melanoma and benign nevi. Chin SY, Wu PR, Shih YH, Yeh CM, Lee WR, Shen SC, Yeh KT, Jiang MC, Tseng JT., Free PMC Article | 03/5/2016 |
These results indicate that CSE1L is associated with viability and apoptosis, cellular adhesion and invasion, thus implicating CSE1L in the progression of colorectal cancer. | Cellular apoptosis susceptibility (chromosome segregation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer. Alnabulsi A, Agouni A, Mitra S, Garcia-Murillas I, Carpenter B, Bird S, Murray GI. | 01/10/2015 |
The cellular apoptosis susceptibility/importin-alpha1 transport cycle is linked to X-linked inhibitor (XIAP) and is required to maintain tumor cell survival in hepatocellular carcinoma. | Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer. Winkler J, Ori A, Holzer K, Sticht C, Dauch D, Eiteneuer EM, Pinna F, Geffers R, Ehemann V, Andres-Pons A, Breuhahn K, Longerich T, Bermejo JL, Gretz N, Zender L, Schirmacher P, Beck M, Singer S. | 11/8/2014 |