| Citrate synthase lysine K215 hypoacetylation contributes to microglial citrate accumulation and pro-inflammatory functions after traumatic brain injury. | Citrate synthase lysine K215 hypoacetylation contributes to microglial citrate accumulation and pro-inflammatory functions after traumatic brain injury.
Zhang F, Lv T, Li J, Lian J, Wu H, Jin Y, Jia F, Zhang X., Free PMC Article | 03/1/2024 |
| The left-lateralisation of citrate synthase activity in the anterior cingulate cortex of male violent suicide victims. | The left-lateralisation of citrate synthase activity in the anterior cingulate cortex of male violent suicide victims.
Karnecki K, Świerczyński J, Steiner J, Krzyżanowska M, Kaliszan M, Gos T., Free PMC Article | 08/28/2023 |
| The Novel Role of Mitochondrial Citrate Synthase and Citrate in the Pathophysiology of Alzheimer's Disease. | The Novel Role of Mitochondrial Citrate Synthase and Citrate in the Pathophysiology of Alzheimer's Disease.
Chhimpa N, Singh N, Puri N, Kayath HP., Free PMC Article | 08/4/2023 |
| Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material. | Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material.
Roosterman D, Cottrell GS., Free PMC Article | 09/11/2021 |
| The active sites of the citrate synthase is almost identical, the differences in reactions catalyzed by citrate synthase are caused by residues that are in the vicinity of the active site and influence conformational changes of the citrate synthase. | Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.
Schlachter CR, Klapper V, Radford T, Chruszcz M. | 04/18/2020 |
| citrate synthase and ACSS1 have tumorigenic functions in hepatocellular carcinoma | Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma.
Zhang J, Baddoo M, Han C, Strong MJ, Cvitanovic J, Moroz K, Dash S, Flemington EK, Wu T., Free PMC Article | 02/24/2018 |
| Citrate synthase activity was lower in patients with heart failure with preserved ejection fraction compared to controls. | Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance.
Molina AJ, Bharadwaj MS, Van Horn C, Nicklas BJ, Lyles MF, Eggebeen J, Haykowsky MJ, Brubaker PH, Kitzman DW., Free PMC Article | 01/6/2018 |
| mir-122 and its targets G6PC3, ALDOA and CS play roles in the hypoxia responses that regulate glucose and energy metabolism and can serve as hypoxia biomarkers. | G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers.
Zeng Y, Lv Y, Tao L, Ma J, Zhang H, Xu H, Xiao B, Shi Q, Ma K, Chen L., Free PMC Article | 12/9/2017 |
| METTL12 methylates CS on Lys-395, which is localized in the CS active site. Interestingly, the METTL12-mediated methylation inhibited CS activity and was blocked by the CS substrate oxaloacetate. | Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation.
Małecki J, Jakobsson ME, Ho AYY, Moen A, Rustan AC, Falnes PØ., Free PMC Article | 11/4/2017 |
| Data suggest that METTL12, localized in mitochondrial matrix, modifies/methylates Lys368 of citrate synthase in external surface region close to its catalytic site; addition/removal of methylation has no effect on citrate synthase activity; Lys368 occurs in highly conserved sequence of amino acid residues of citrate synthase. (METTL12 = methyltransferase-like protein 12) | Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase.
Rhein VF, Carroll J, Ding S, Fearnley IM, Walker JE., Free PMC Article | 09/30/2017 |
| Data suggest that downregulation of citrate synthase (CS) expression in 293T cells leads to low level of ATP production, excessive superoxide formation and cell apoptosis, which implies a possible mechanism for hearing loss in A/J mice. | Reduced expression of citrate synthase leads to excessive superoxide formation and cell apoptosis.
Cai Q, Zhao M, Liu X, Wang X, Nie Y, Li P, Liu T, Ge R, Han F. | 06/24/2017 |
| Hence, we conclude that SIRT3 exhibits neuroprotection via deacetylating and increasing mitochondrial enzyme activities. | SIRT3 deacetylated and increased citrate synthase activity in PD model.
Cui XX, Li X, Dong SY, Guo YJ, Liu T, Wu YC. | 06/10/2017 |
| Paretic muscle in hemiparetic stroke survivors had lower CS concentration. | Skeletal muscle fiber characteristics and oxidative capacity in hemiparetic stroke survivors.
Severinsen K, Dalgas U, Overgaard K, Pedersen AR, Ørtenblad N, Lund C, Jakobsen JK, Andersen H. | 09/10/2016 |
| The citrate synthase knockdown cells exhibited severe defects in respiratory activity and marked decreases in ATP production, but great increases in glycolytic metabolism. | Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy.
Lin CC, Cheng TL, Tsai WH, Tsai HJ, Hu KH, Chang HC, Yeh CW, Chen YC, Liao CC, Chang WT., Free PMC Article | 04/13/2013 |
| Citrate synthase (CS) is a direct RORalpha target gene and one mechanism by which RORalpha regulates lipid metabolism is via regulation of CS expression. | Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα).
Crumbley C, Wang Y, Banerjee S, Burris TP., Free PMC Article | 07/28/2012 |
| These results provide an important basis for the study of mitochondrial dysfunction due to aberrant CSa trafficking. | Identification and characterization of the mitochondrial targeting sequence and mechanism in human citrate synthase.
Cheng TL, Liao CC, Tsai WH, Lin CC, Yeh CW, Teng CF, Chang WT. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Single nucleotide polymorphisms in succinate dehydrogenase subunits and citrate synthase genes: association results for impaired spermatogenesis.
Bonache S, Martínez J, Fernández M, Bassas L, Larriba S. | 03/13/2008 |
| Responses of skeletal and cardiac muscles in CS activity and gene expression at 1 and 48 h after endurance training. Acute effect of exercise on training-induced elevation in CS activity in rat soleus but not ventricle muscles. | Citrate synthase expression and enzyme activity after endurance training in cardiac and skeletal muscles.
Siu PM, Donley DA, Bryner RW, Alway SE. | 01/21/2010 |
| possible role of CS-specific autoantibodies in the pathomechanism of allograft vasculopathy | Detection of citrate synthase-reacting autoantibodies after heart transplantation: an epitope mapping study.
Petrohai A, Nagy G, Bosze S, Hudecz F, Zsiros E, Paragh G, Nyárády Z, Németh P, Berki T. | 01/21/2010 |
| It is likely that enhanced citrate synthase activity contributes to the conversion of glucose to lipids in pancreatic cancer providing substrate for membrane lipids synthesis. | Enhanced citrate synthase activity in human pancreatic cancer.
Schlichtholz B, Turyn J, Goyke E, Biernacki M, Jaskiewicz K, Sledzinski Z, Swierczynski J. | 01/21/2010 |