| FSHR-mTOR-HIF1 signaling alleviates mouse follicles from AMPK-induced atresia. | FSHR-mTOR-HIF1 signaling alleviates mouse follicles from AMPK-induced atresia.
Liu L, Hao M, Zhang J, Chen Z, Zhou J, Wang C, Zhang H, Wang J. | 11/8/2023 |
| The Luteinizing Hormone Receptor Knockout Mouse as a Tool to Probe the In Vivo Actions of Gonadotropic Hormones/Receptors in Females. | The Luteinizing Hormone Receptor Knockout Mouse as a Tool to Probe the In Vivo Actions of Gonadotropic Hormones/Receptors in Females.
Jonas KC, Rivero Müller A, Oduwole O, Peltoketo H, Huhtaniemi I., Free PMC Article | 10/23/2021 |
| FSHR ablation induces depression-like behaviors. | FSHR ablation induces depression-like behaviors.
Bi WK, Shao SS, Li ZW, Ruan YW, Luan SS, Dong ZH, Wang J, Wu SS, Guo T, Ma SZ, Gao L, Zhao JJ, He Z., Free PMC Article | 05/29/2021 |
| FSH signaling is involved in affective disorders. | FSH signaling is involved in affective disorders.
Bi WK, Luan SS, Wang J, Wu SS, Jin XC, Fu YL, Gao L, Zhao JJ, He Z. | 12/12/2020 |
| Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis. | Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis.
Oduwole OO, Peltoketo H, Poliandri A, Vengadabady L, Chrusciel M, Doroszko M, Samanta L, Owen L, Keevil B, Rahman NA, Huhtaniemi IT., Free PMC Article | 09/14/2019 |
| Fshr is essential for normal angiogenesis of the fetal placental vasculature. | Deletion of fetoplacental Fshr inhibits fetal vessel angiogenesis in the mouse placenta.
Stilley JAW, Segaloff DL., Free PMC Article | 05/4/2019 |
| These data highlight an important interdependency between the potent pro-inflammatory cytokine IL1A and Fshr expression. | Interleukin 1-alpha deficiency increases the expression of Follicle-stimulating hormone receptors in granulosa cells.
Uri-Belapolsky S, Miller I, Shaish A, Levi M, Harats D, Ninio-Many L, Kamari Y, Shalgi R. | 03/17/2018 |
| Mouse chondrocytes and human articular cartilage express functional FSHR. Moreover, FSH can act on chondrocytes and cause genetic changes. | Expression of FSHR in chondrocytes and the effect of FSH on chondrocytes.
Kong D, Guan Q, Li G, Xin W, Qi X, Guo Y, Zhao J, Xu J, Sun S, Gao L. | 12/30/2017 |
| Study demonstrates expression of follicle-stimulating hormone receptor (FSHR) and a direct action of follicle-stimulating hormone on testicular stem/germ cells possibly mediated via alternatively spliced growth factor type 1 receptor FSHR3 in mice. | Testicular Stem Cells Express Follicle-Stimulating Hormone Receptors and Are Directly Modulated by FSH.
Patel H, Bhartiya D. | 09/30/2017 |
| FSHR and LHR proteins are significantly upregulated in CCs surrounding oocytes arrested at the 2-cell stage, reflecting their developmental incompetence. | FSH and LH receptors are differentially expressed in cumulus cells surrounding developmentally competent and incompetent mouse fully grown antral oocytes.
Vigone G, Merico V, Redi CA, Mazzini G, Garagna S, Zuccotti M. | 04/8/2017 |
| Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1, LHR, and FSHR | Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1, LHR, and FSHR of mice.
Wei S, Guo H, Gong Z, Zhang F, Ma Z. | 03/25/2017 |
| Brca1(GC-/-) models reveal that specific intra-follicular Brca1 loss alone, or combined with cancer-promoting genetic (Trp53 loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors. | Granulosa Cell-Specific Brca1 Loss Alone or Combined with Trp53 Haploinsufficiency and Transgenic FSH Expression Fails to Induce Ovarian Tumors.
Upton DH, Fuller ES, Colvin EK, Walters KA, Jimenez M, Desai R, Handelsman DJ, Howell VM, Allan CM., Free PMC Article | 03/19/2016 |
| Data (including date from knockout mice) suggest that Fshr is expressed early in pregnany in placenta and other extragonadal tissues of fetoplacental unit; expression is particularly strong at term. | FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice.
Stilley JA, Christensen DE, Dahlem KB, Guan R, Santillan DA, England SK, Al-Hendy A, Kirby PA, Segaloff DL., Free PMC Article | 05/23/2015 |
| Sertoli cell-specific expression of MTA2 is required for transcriptional regulation of FSHR gene during spermatogenesis. | Sertoli cell-specific expression of metastasis-associated protein 2 (MTA2) is required for transcriptional regulation of the follicle-stimulating hormone receptor (FSHR) gene during spermatogenesis.
Zhang S, Li W, Zhu C, Wang X, Li Z, Zhang J, Zhao J, Hu J, Li T, Zhang Y., Free PMC Article | 03/2/2013 |
| By day 20 and in adult animals total AR or FSHR ablation significantly reduced Leydig cell numbers but Sertoli cell specific AR ablation had no effect. | Testicular development in mice lacking receptors for follicle stimulating hormone and androgen.
O'Shaughnessy PJ, Monteiro A, Abel M., Free PMC Article | 09/1/2012 |
| The results demonstrate that gain-of-function mutations of the FSHR in mice bring about distinct and clear changes in ovarian function | Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess.
Peltoketo H, Strauss L, Karjalainen R, Zhang M, Stamp GW, Segaloff DL, Poutanen M, Huhtaniemi IT., Free PMC Article | 04/12/2010 |
| USF1 and USF2 bind the Fshr promoter and revealed differences between Sertoli and granulosa cells in compensatory responses to USF loss and the USF dimeric composition required for Fshr transcription | In vivo regulation of follicle-stimulating hormone receptor by the transcription factors upstream stimulatory factor 1 and upstream stimulatory factor 2 is cell specific.
Hermann BP, Hornbaker K, Rice DA, Sawadogo M, Heckert LL., Free PMC Article | 01/21/2010 |
| Follitropin-receptor knockout (FORKO) females have an impaired natriuretic peptide system, which may contribute to the susceptibility of FORKO mice to developing age-related hypertension previously shown in these animals. | Impairment of the natriuretic peptide system in follitropin receptor knockout mice and reversal by estradiol: implications for obesity-associated hypertension in menopause.
Belo NO, Sairam MR, Dos Reis AM. | 01/21/2010 |
| Gender-specific impairments in translocation of phosphorylated map erk kinases were found in the CNS structures in aged FSH-R knockout mice. | Impairments of heat shock protein expression and MAPK translocation in the central nervous system of follitropin receptor knockout mice.
Rumora L, Lovrić J, Sairam MR, Maysinger D. | 01/21/2010 |
| FSHR gene expression is regulated distinctly in the osteoclast, and differently from other cells, such as the ovarian follicular and Leydig cells. | Regulation of FSH receptor promoter activation in the osteoclast.
Zaidi S, Zhu LL, Mali R, Iqbal J, Yang G, Zaidi M, Sun L. | 01/21/2010 |
| haploinsufficiency of the follicle-stimulating hormone receptor accelerates oocyte loss inducing early reproductive senescence and biological aging in mice | Haploinsufficiency of the follicle-stimulating hormone receptor accelerates oocyte loss inducing early reproductive senescence and biological aging in mice.
Danilovich N, Sairam MR. | 01/21/2010 |
| The complex cellular biology of follitropin receptors that may interact differently with polymorphic forms (glycosylation variants) of FSH represents an intricate scheme to regulate hormone signaling. | The tale of follitropin receptor diversity: a recipe for fine tuning gonadal responses?
Sairam MR, Babu PS. | 01/21/2010 |
| shrinkage in epididymal epithelial areas observed in follicle stimulating hormone receptor knockout mice | Effects of FSH receptor deletion on epididymal tubules and sperm morphology, numbers, and motility.
Grover A, Smith CE, Gregory M, Cyr DG, Sairam MR, Hermo L. | 01/21/2010 |
| These data suggest that FSH-R3 signaling promotes proliferation of ovarian cancer cells. | FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor.
Li Y, Ganta S, Cheng C, Craig R, Ganta RR, Freeman LC., Free PMC Article | 01/21/2010 |
| FORKO mice developed age-dependent declines in bone mineral density and trabecular bone volume of the lumbar spine and femur, which could be partly reversed by ovarian transplantation. | Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone.
Gao J, Tiwari-Pandey R, Samadfam R, Yang Y, Miao D, Karaplis AC, Sairam MR, Goltzman D. | 01/21/2010 |