| Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal morphology and development. | Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal morphology and development.
Fischer TT, Nguyen LD, Ehrlich BE., Free PMC Article | 10/23/2021 |
| Mice lacking neuronal calcium sensor-1 show social and cognitive deficits. | Mice lacking neuronal calcium sensor-1 show social and cognitive deficits.
Ng E, Georgiou J, Avila A, Trought K, Mun HS, Hodgson M, Servinis P, Roder JC, Collingridge GL, Wong AHC. | 05/29/2021 |
| Contribution of neuronal calcium sensor 1 (Ncs-1) to anxiolytic-like and social behavior mediated by valproate and Gsk3 inhibition. | Contribution of neuronal calcium sensor 1 (Ncs-1) to anxiolytic-like and social behavior mediated by valproate and Gsk3 inhibition.
Magno LAV, Tenza-Ferrer H, Collodetti M, Nicolau ES, Khlghatyan J, Del'Guidice T, Romano-Silva MA, Beaulieu JM., Free PMC Article | 12/12/2020 |
| NCS-1 knockout exacerbated nigral neurodegeneration and downregulated Cav2.3. Cav2.3 deficiency upregulated transcripts for NCS-1. | Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease.
Benkert J, Hess S, Roy S, Beccano-Kelly D, Wiederspohn N, Duda J, Simons C, Patil K, Gaifullina A, Mannal N, Dragicevic E, Spaich D, Müller S, Nemeth J, Hollmann H, Deuter N, Mousba Y, Kubisch C, Poetschke C, Striessnig J, Pongs O, Schneider T, Wade-Martins R, Patel S, Parlato R, Frank T, Kloppenburg P, Liss B., Free PMC Article | 03/7/2020 |
| Phosphorylation of CaMKII-alpha, known to trigger long-term potentiation and increase BDNF levels, was significantly reduced in the Ncs1-/- mouse brain. Further, electric potential stimulation, which increases the levels of BDNF and promotes spatial learning, significantly increased the levels of NCS-1 concomitant with phosphorylated CaMKII-alpha in the hippocampus; suggesting a close relationship between NCS-1 and CaM... | Possible Signaling Pathways Mediating Neuronal Calcium Sensor-1-Dependent Spatial Learning and Memory in Mice.
Nakamura TY, Nakao S, Nakajo Y, Takahashi JC, Wakabayashi S, Yanamoto H., Free PMC Article | 08/12/2017 |
| these data demonstrate that NCS-1 contributes to stress tolerance in cardiomyocytes at least in part by activating certain Ca(2+)-dependent survival pathways that promote mitochondrial biosynthesis/function and detoxification pathways. | Neuronal Ca(2+) sensor-1 contributes to stress tolerance in cardiomyocytes via activation of mitochondrial detoxification pathways.
Nakamura TY, Nakao S, Wakabayashi S. | 06/3/2017 |
| These studies identify novel roles for NCS-1 in regulating activity-dependent striatal dopamine release and aspects of motivated behavior | Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens.
Ng E, Varaschin RK, Su P, Browne CJ, Hermainski J, Le Foll B, Pongs O, Liu F, Trudeau LE, Roder JC, Wong AH. | 10/22/2016 |
| elevated expression of neuronal calcium sensor 1 (Ncs1) and dopamine type-2 receptors upon self-directed exploration, is reported. | Self-directed exploration provides a Ncs1-dependent learning bonus.
Mun HS, Saab BJ, Ng E, McGirr A, Lipina TV, Gondo Y, Georgiou J, Roder JC., Free PMC Article | 10/22/2016 |
| IGF-1 strengthens the interaction between NCS-1 and IP3R in the process of regulation of nuclear Ca2+ signaling in cardiomyocytes. | Stimulus-dependent regulation of nuclear Ca2+ signaling in cardiomyocytes: a role of neuronal calcium sensor-1.
Nakao S, Wakabayashi S, Nakamura TY., Free PMC Article | 04/2/2016 |
| data implicate NCS-1 in exploratory activity, memory and mood-related behaviors, suggesting that NCS-1 gene ablation may result in phenotypic abnormalities associated with neuropsychiatric disorders | NCS-1 deficiency causes anxiety and depressive-like behavior with impaired non-aversive memory in mice.
de Rezende VB, Rosa DV, Comim CM, Magno LA, Rodrigues AL, Vidigal P, Jeromin A, Quevedo J, Romano-Silva MA. | 12/20/2014 |
| NCS-1 transgene is upregulated in hypertrophic hearts, while hormone-induced hypertrophy is largely prevented in Ncs1-deficient hearts. | Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals.
Nakamura TY, Jeromin A, Mikoshiba K, Wakabayashi S. | 10/22/2011 |
| PI 4-kinase functions to negatively regulate GLUT4 translocation through its interaction with NCS-1. | NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway.
Mora S, Durham PL, Smith JR, Russo AF, Jeromin A, Pessin JE. | 01/21/2010 |
| During development, expression of NCS-1 in the olfactory epithelium was localized in the dendritic knobs and axons of olfactory sensory neurons. In the developing olfactory bulb, NCS-1 was expressed in the processes of mitral/tufted and granule cells. | Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway.
Treloar HB, Uboha U, Jeromin A, Greer CA. | 01/21/2010 |
| NCS-1 is an accessory subunit of Kv4-encoded I(to,f) channels that functions to regulate I(to,f) density in the mammalian myocardium. | Modulation of Kv4-encoded K(+) currents in the mammalian myocardium by neuronal calcium sensor-1.
Guo W, Malin SA, Johns DC, Jeromin A, Nerbonne JM. | 01/21/2010 |
| NCS-1 should be considered an important potential Kv4 regulatory subunit, particularly in the immature heart. | Developmental expression of NCS-1 (frequenin), a regulator of Kv4 K+ channels, in mouse heart.
Nakamura TY, Sturm E, Pountney DJ, Orenzoff B, Artman M, Coetzee WA. | 01/21/2010 |