| 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity. | 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity.
Deng Y, Hahn Q, Yu L, Zhu Z, Boyer JA, Wang J, Kong D, Carey LM, Hepperla AJ, Simon JM, Temple B, Zhang Z, Zhang Y, Santos C, Frank JE, Herring LE, Wang X, Dokholyan NV, Campbell SL, Baldwin AS, Damania B, Zhang Q, Liu P., Free PMC Article | 10/23/2024 |
| Persistent FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice. | Persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice.
Stephens GS, Park J, Eagle A, You J, Silva-Pérez M, Fu CH, Choi S, Romain CPS, Sugimoto C, Buffington SA, Zheng Y, Costa-Mattioli M, Liu Y, Robison AJ, Chin J., | 08/21/2024 |
| Manipulating DeltaFOSB in D1-Type Medium Spiny Neurons of the Nucleus Accumbens Reshapes Whole-Brain Functional Connectivity. | Manipulating ΔFOSB in D1-Type Medium Spiny Neurons of the Nucleus Accumbens Reshapes Whole-Brain Functional Connectivity.
Sourty M, Nasseef MT, Champagnol-Di Liberti C, Mondino M, Noblet V, Parise EM, Markovic T, Browne CJ, Darcq E, Nestler EJ, Kieffer BL., Free PMC Article | 01/4/2024 |
| LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73. | LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73.
Wang Y, Liu M, Liu X, Guo X., Free PMC Article | 05/24/2023 |
| Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates DeltaFosB and GluR2 expression. | Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression.
Nguyen ATM, Quach TVB, Kotha P, Chien SY, MacDonald IJ, Lane HY, Tu CH, Lin JG, Chen YH., Free PMC Article | 11/6/2021 |
| Circuit-specific hippocampal DeltaFosB underlies resilience to stress-induced social avoidance. | Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance.
Eagle AL, Manning CE, Williams ES, Bastle RM, Gajewski PA, Garrison A, Wirtz AJ, Akguen S, Brandel-Ankrapp K, Endege W, Boyce FM, Ohnishi YN, Mazei-Robison M, Maze I, Neve RL, Robison AJ., Free PMC Article | 09/26/2020 |
| DeltaFosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy expenditure. | ΔFosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy expenditure.
Idelevich A, Sato K, Nagano K, Rowe G, Gori F, Baron R., Free PMC Article | 09/26/2020 |
| Using transgenic expression of mouse DeltaFosB in the striatum of parkinsonian primates, study shows that elevated levels of DeltaFosB lead to l-Dopa-induced dyskinesia (LID) development in the absence of chronic l-Dopa exposure. The physiological and molecular changes associated with LID are also replicated in this model. These findings suggest that DeltaFosB elevation is responsible for LID generation. | Role of striatal ΔFosB in l-Dopa-induced dyskinesias of parkinsonian nonhuman primates.
Beck G, Singh A, Zhang J, Potts LF, Woo JM, Park ES, Mochizuki H, Mouradian MM, Papa SM., Free PMC Article | 04/11/2020 |
| Fosb expression in the hippocampal subgranular zone is necessary for both hippocampal neurogenesis and memory formation. | Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning.
Manning CE, Eagle AL, Kwiatkowski CC, Achargui R, Woodworth H, Potter E, Ohnishi Y, Leinninger GM, Robison AJ., Free PMC Article | 12/28/2019 |
| data strongly support a dissociable cell-type-specific role for DeltaFosB in the nucleus accumbens in modulating aggression and aggression reward | Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression.
Aleyasin H, Flanigan ME, Golden SA, Takahashi A, Menard C, Pfau ML, Multer J, Pina J, McCabe KA, Bhatti N, Hodes GE, Heshmati M, Neve RL, Nestler EJ, Heller EA, Russo SJ., Free PMC Article | 11/2/2019 |
| Fosb-targeted histone acetylation in D2-MSNs or histone methylation in D1-MSNs promotes a stress-susceptible, depressive-like phenotype, while histone methylation in D2-MSNs or histone acetylation in D1-MSNs increases resilience to social stress as quantified by social interaction behavior and sucrose preference. | Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress.
Hamilton PJ, Burek DJ, Lombroso SI, Neve RL, Robison AJ, Nestler EJ, Heller EA., Free PMC Article | 08/4/2018 |
| study provides key insights into functional domains regulated by FosB in the hippocampus, emphasizing remarkably different programs of gene regulation under physiological and pathological conditions | Genome-wide profiling reveals functional diversification of ∆FosB gene targets in the hippocampus of an Alzheimer's disease mouse model.
You JC, Stephens GS, Fu CH, Zhang X, Liu Y, Chin J., Free PMC Article | 04/7/2018 |
| These findings suggest that GosB may regulate mammary epithelial cells milk fat synthesis and apoptosis via PPARgamma in mouse mammary glands. | GosB Inhibits Triacylglycerol Synthesis and Promotes Cell Survival in Mouse Mammary Epithelial Cells.
Xu G, Duan S, Hou J, Wei Z, Zhao G., Free PMC Article | 01/27/2018 |
| propose that chronic suppression of calbindin by DeltaFosB is one mechanism through which intermittent seizures drive persistent cognitive deficits in conditions accompanied by recurrent seizures | Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits.
You JC, Muralidharan K, Park JW, Petrof I, Pyfer MS, Corbett BF, LaFrancois JJ, Zheng Y, Zhang X, Mohila CA, Yoshor D, Rissman RA, Nestler EJ, Scharfman HE, Chin J., Free PMC Article | 12/30/2017 |
| Both CREB and deltaFosB play a role in the induction of this behavioural sensitization. | Changes in CREB and deltaFosB are associated with the behavioural sensitization induced by methylenedioxypyrovalerone.
Buenrostro-Jáuregui M, Ciudad-Roberts A, Moreno J, Muñoz-Villegas P, López-Arnau R, Pubill D, Escubedo E, Camarasa J. | 12/30/2017 |
| Study investigated effects of chronic variable mild stress (CVMS) in non-injected, vehicle and imipramine-treated KO mice vs. wildtype (WT) counterparts and mapped the CVMS-related FosB response in 18 brain areas; found that PACAP deficiency affects neuronal reactivity in a brain area-specific manner in stress centers | Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers.
Kormos V, Gáspár L, Kovács LÁ, Farkas J, Gaszner T, Csernus V, Balogh A, Hashimoto H, Reglődi D, Helyes Z, Gaszner B. | 07/15/2017 |
| abnormal regulation of MSK1 contributes to the development of L-DOPA-induced dyskinesia and to the concomitant increase in striatal FosB, which may occur via increased histone H3 phosphorylation at the fosB promoter | A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression.
Feyder M, Södersten E, Santini E, Vialou V, LaPlant Q, Watts EL, Spigolon G, Hansen K, Caboche J, Nestler EJ, Fisone G., Free PMC Article | 10/22/2016 |
| The most highly stereotypic mice showed the most elevated FosB/DeltaFosB activity in the nucleus accumbens | Cage-induced stereotypic behaviour in laboratory mice covaries with nucleus accumbens FosB/ΔFosB expression.
Phillips D, Choleris E, Ervin KS, Fureix C, Harper L, Reynolds K, Niel L, Mason GJ. | 10/22/2016 |
| FosB/DeltaFosB immunoreactivity was transiently increased in hippocampus and parahippocampal cortices by 6-Hz corneal stimulation. FosB induction was primarily localized in pyramidal neurons. | Repeated 6-Hz Corneal Stimulation Progressively Increases FosB/ΔFosB Levels in the Lateral Amygdala and Induces Seizure Generalization to the Hippocampus.
Giordano C, Vinet J, Curia G, Biagini G., Free PMC Article | 06/28/2016 |
| This study demonstrate that the DeltaFosB is induced in the hippocampus by learning, regulates the shape of hippocampal synapses, and is required for memory formation, opening up a host of new possibilities for hippocampal transcriptional regulation. | Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning.
Eagle AL, Gajewski PA, Yang M, Kechner ME, Al Masraf BS, Kennedy PJ, Wang H, Mazei-Robison MS, Robison AJ., Free PMC Article | 01/16/2016 |
| These findings confirm the unique role of DeltaFosB in the nucleus accumbens in controlling responses to drugs of abuse and stress. | Functional role of the N-terminal domain of ΔFosB in response to stress and drugs of abuse.
Ohnishi YN, Ohnishi YH, Vialou V, Mouzon E, LaPlant Q, Nishi A, Nestler EJ., Free PMC Article | 12/26/2015 |
| D1Rs play a major role in THC-mediated DeltaFosB induction. | Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ9-Tetrahydrocannabinol-Mediated Induction of ΔFosB in the Mouse Forebrain.
Lazenka MF, Tomarchio AJ, Lichtman AH, Greengard P, Flajolet M, Selley DE, Sim-Selley LJ., Free PMC Article | 10/10/2015 |
| Histone methylation or acetylation at the Fosb locus in nucleus accumbens, was sufficient to control drug- and stress-evoked behavioral responses. | Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors.
Heller EA, Cates HM, Peña CJ, Sun H, Shao N, Feng J, Golden SA, Herman JP, Walsh JJ, Mazei-Robison M, Ferguson D, Knight S, Gerber MA, Nievera C, Han MH, Russo SJ, Tamminga CS, Neve RL, Shen L, Zhang HS, Zhang F, Nestler EJ., Free PMC Article | 02/7/2015 |
| Findings demonstrate that, under excitotoxicity, Fosb products contribute to a neuroinflammatory response in the hippocampus through regulation of microglial C5ar1 and C5ar2 expression | Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia.
Nomaru H, Sakumi K, Katogi A, Ohnishi YN, Kajitani K, Tsuchimoto D, Nestler EJ, Nakabeppu Y., Free PMC Article | 02/7/2015 |
| These results indicate that social stress-induced behavioral deficits are mediated partly by molecular adaptations in mPFC involving DeltaFosB and CCK through cortical projections to distinct subcortical targets. | Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of ΔFosB.
Vialou V, Bagot RC, Cahill ME, Ferguson D, Robison AJ, Dietz DM, Fallon B, Mazei-Robison M, Ku SM, Harrigan E, Winstanley CA, Joshi T, Feng J, Berton O, Nestler EJ., Free PMC Article | 05/24/2014 |