| FMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury. | FMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury.
Huang X, Zhu Z, Du M, Wu C, Fu J, Zhang J, Tan W, Wu B, Liu L, Liao ZB., Free PMC Article | 06/20/2024 |
| Dark pigmentation and related low FMOD expression increase IL-3 and facilitateplasmacytoid dendritic cell maturation. | Dark pigmentation and related low FMOD expression increase IL-3 and facilitateplasmacytoid dendritic cell maturation.
Halasi M, Talmon A, Tal Y, Yosipovitch G, Adini I. | 05/23/2023 |
| Extracellular matrix components and elasticity regulate mouse vaginal epithelial differentiation induced by mesenchymal cellsdagger. | Extracellular matrix components and elasticity regulate mouse vaginal epithelial differentiation induced by mesenchymal cells†.
Nakajima T, Kozuma M, Hirasawa T, Matsunaga YT, Tomooka Y. | 01/8/2022 |
| Interaction of Fibromodulin and Myostatin to Regulate Skeletal Muscle Aging: An Opposite Regulation in Muscle Aging, Diabetes, and Intracellular Lipid Accumulation. | Interaction of Fibromodulin and Myostatin to Regulate Skeletal Muscle Aging: An Opposite Regulation in Muscle Aging, Diabetes, and Intracellular Lipid Accumulation.
Lee EJ, Ahmad SS, Lim JH, Ahmad K, Shaikh S, Lee YS, Park SJ, Jin JO, Lee YH, Choi I., Free PMC Article | 11/22/2021 |
| OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton. | OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton.
Kram V, Jani P, Kilts TM, Li L, Chu EY, Young MF., Free PMC Article | 10/16/2021 |
| Influence of microcurrent on the modulation of remodelling genes in a wound healing assay. | Influence of microcurrent on the modulation of remodelling genes in a wound healing assay.
Silva DFD, de Oliveira Fujii L, Chiarotto GB, de Oliveira CA, de Andrade TAM, de Oliveira ALR, Esquisatto MAM, Mendonça FAS, Dos Santos GMT, de Aro AA. | 05/22/2021 |
| this study suggests that downregulation of miR-340-5p plays a role in promoting cell proliferation and suppressing cell apoptosis of chondrocytes in Osteoarthritis (OA) mice through inhibition of the ERK signaling pathway via the FMOD gene. | Downregulated microRNA-340-5p promotes proliferation and inhibits apoptosis of chondrocytes in osteoarthritis mice through inhibiting the extracellular signal-regulated kinase signaling pathway by negatively targeting the FMOD gene.
Zhang W, Cheng P, Hu W, Yin W, Guo F, Chen A, Huang H. | 10/5/2019 |
| our data indicates that Bgn and Fmod expressed by the bone forming cells, are novel coupling ECM components that control bone mass through sequestration of TNFalpha and/or RANKL, thereby adjusting their bioavailability in order to regulate osteoclastogenesis. | Small leucine rich proteoglycans, a novel link to osteoclastogenesis.
Kram V, Kilts TM, Bhattacharyya N, Li L, Young MF., Free PMC Article | 06/29/2019 |
| The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling. | The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling.
Andenæs K, Lunde IG, Mohammadzadeh N, Dahl CP, Aronsen JM, Strand ME, Palmero S, Sjaastad I, Christensen G, Engebretsen KVT, Tønnessen T., Free PMC Article | 01/19/2019 |
| FMOD affected the expressions of the Cav1.1 and Cav3.1 genes. FMOD regulates calcium channel activity. The mRNA expressions of Cav1.1 and Cav3.1 increased during muscle regeneration. | Fibromodulin modulates myoblast differentiation by controlling calcium channel.
Lee EJ, Nam JH, Choi I. | 12/22/2018 |
| Studies in knockout, obese, and diabetic mouse models helped characterize the operation of a novel FMOD-based regulatory circuit that controls myoblast switching from a myogenic to a lipid accumulation fate. FMOD regulation of myoblasts is an essential part of the myogenic program, and it offers opportunities for the development of therapeutics for the treatment of different muscle diseases | Fibromodulin and regulation of the intricate balance between myoblast differentiation to myocytes or adipocyte-like cells.
Lee EJ, Jan AT, Baig MH, Ahmad K, Malik A, Rabbani G, Kim T, Lee IK, Lee YH, Park SY, Choi I. | 10/27/2018 |
| impact of FMOD deficiency on the development of experimental skin fibrosis is limited | Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis.
Andréasson K, Gustafsson R, Rydell-Törmänen K, Westergren-Thorsson G, Saxne T, Hesselstrand R. | 01/27/2018 |
| Fibromodulin can be a unique effector of dense collagen matrix assembly in tumor stroma and, without affecting other major matrix components or the cellular composition, can function as a main agent in tumor barrier function | Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma.
Olsson PO, Kalamajski S, Maccarana M, Oldberg Å, Rubin K., Free PMC Article | 10/14/2017 |
| The data suggest a fibromodulin-modulated collagen cross-linking mechanism where fibromodulin binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites. | Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase.
Kalamajski S, Bihan D, Bonna A, Rubin K, Farndale RW., Free PMC Article | 09/3/2016 |
| Suggest a more complex role for collagen in plaque stability than previously anticipated in fibromodulin-deficient/ApoE-null atherosclerotic mice. | Fibromodulin deficiency reduces low-density lipoprotein accumulation in atherosclerotic plaques in apolipoprotein E-null mice.
Shami A, Gustafsson R, Kalamajski S, Krams R, Segers D, Rauch U, Roos G, Nilsson J, Oldberg Å, Hultgårdh-Nilsson A. | 03/16/2013 |
| The expression of decreased in the medial, basolateral, and central amygdala regions after chronic immobilization stress in mice. | Decreased expression of extracellular matrix proteins and trophic factors in the amygdala complex of depressed mice after chronic immobilization stress.
Jung S, Lee Y, Kim G, Son H, Lee DH, Roh GS, Kang SS, Cho GJ, Choi WS, Kim HJ., Free PMC Article | 12/22/2012 |
| Hepatic fibromodulin activates hepatic stellate cells and promotes collagen I deposition, which leads to liver fibrosis. | Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.
Mormone E, Lu Y, Ge X, Fiel MI, Nieto N., Free PMC Article | 05/12/2012 |
| The differential effects of Fmod deficiency on bones and teeth appear to diverge in adult mice. | Differential effects of fibromodulin deficiency on mouse mandibular bones and teeth: a micro-CT time course study.
Goldberg M, Marchadier A, Vidal C, Harichane Y, Kamoun-Goldrat A, Kellermann O, Kilts T, Young M., Free PMC Article | 12/31/2011 |
| critical for temporomandibular joint subchondral bone integrity | Role of subchondral bone during early-stage experimental TMJ osteoarthritis.
Embree M, Ono M, Kilts T, Walker D, Langguth J, Mao J, Bi Y, Barth JL, Young M., Free PMC Article | 11/26/2011 |
| Fibromodulin suppresses nuclear factor-kappaB activity by inducing the delayed degradation of IKBA via a JNK-dependent pathway coupled to fibroblast apoptosis. | Fibromodulin suppresses nuclear factor-kappaB activity by inducing the delayed degradation of IKBA via a JNK-dependent pathway coupled to fibroblast apoptosis.
Lee YH, Schiemann WP., Free PMC Article | 04/16/2011 |
| FMOD presence is critical for proper temporospatial coordination of wound healing events and normal TGF-beta bioactivity. | Delayed wound closure in fibromodulin-deficient mice is associated with increased TGF-β3 signaling.
Zheng Z, Nguyen C, Zhang X, Khorasani H, Wang JZ, Zara JN, Chu F, Yin W, Pang S, Le A, Ting K, Soo C., Free PMC Article | 04/16/2011 |
| fibromodulin plays important roles in the regulation of region-specific fibrillogenesis required for the integration of the corneal and scleral matrices and sulcus development required for establishment of the visual axis | Fibromodulin regulates collagen fibrillogenesis during peripheral corneal development.
Chen S, Oldberg A, Chakravarti S, Birk DE., Free PMC Article | 12/11/2010 |
| Biglycan and fibromodulin are novel key players in regulating chondrogenesis and extracellular matrix turnover during temoporomandibular joint osteoarthritis pathology. | Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis.
Embree MC, Kilts TM, Ono M, Inkson CA, Syed-Picard F, Karsdal MA, Oldberg A, Bi Y, Young MF., Free PMC Article | 03/22/2010 |
| Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding. | Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding.
Kalamajski S, Oldberg Å. | 01/21/2010 |
| Dual functions may be related to the different forms of Fmod found in bone versus teeth. | Fibromodulin-deficient mice reveal dual functions for fibromodulin in regulating dental tissue and alveolar bone formation.
Goldberg M, Ono M, Septier D, Bonnefoix M, Kilts TM, Bi Y, Embree M, Ameye L, Young MF., Free PMC Article | 01/21/2010 |