| The causal relationship between immune cells mediating FIT3L, CCL4, OSM, and skin-derived deteriorated tumors. | The causal relationship between immune cells mediating FIT3L, CCL4, OSM, and skin-derived deteriorated tumors.
Gong W, Zhou J, Hou Y, Zhang J, He P, Yu Q., Free PMC Article | 07/26/2024 |
| FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice. | FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice.
Momenilandi M, Lévy R, Sobrino S, Li J, Lagresle-Peyrou C, Esmaeilzadeh H, Fayand A, Le Floc'h C, Guérin A, Della Mina E, Shearer D, Delmonte OM, Yatim A, Mulder K, Mancini M, Rinchai D, Denis A, Neehus AL, Balogh K, Brendle S, Rokni-Zadeh H, Changi-Ashtiani M, Seeleuthner Y, Deswarte C, Bessot B, Cremades C, Materna M, Cederholm A, Ogishi M, Philippot Q, Beganovic O, Ackermann M, Wuyts M, Khan T, Fouéré S, Herms F, Chanal J, Palterer B, Bruneau J, Molina TJ, Leclerc-Mercier S, Prétet JL, Youssefian L, Vahidnezhad H, Parvaneh N, Claeys KG, Schrijvers R, Luka M, Pérot P, Fourgeaud J, Nourrisson C, Poirier P, Jouanguy E, Boisson-Dupuis S, Bustamante J, Notarangelo LD, Christensen N, Landegren N, Abel L, Marr N, Six E, Langlais D, Waterboer T, Ginhoux F, Ma CS, Tangye SG, Meyts I, Lachmann N, Hu J, Shahrooei M, Bossuyt X, Casanova JL, Béziat V., Free PMC Article | 05/31/2024 |
| FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors. | FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors.
Tu HF, Kung YJ, Lim L, Tao J, Hu MH, Cheng M, Xing D, Wu TC, Hung CF., Free PMC Article | 02/8/2024 |
| Identification of dendritic cell precursor from the CD11c[+] cells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand. | Identification of dendritic cell precursor from the CD11c(+) cells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand.
In H, Park JS, Shin HS, Ryu SH, Sohn M, Choi W, Park S, Hwang S, Park J, Che L, Kim TG, Chu MK, Na HY, Park CG., Free PMC Article | 12/20/2023 |
| Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. | Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection.
Sikder MAA, Rashid RB, Ahmed T, Sebina I, Howard DR, Ullah MA, Rahman MM, Lynch JP, Curren B, Werder RB, Simpson J, Bissell A, Morrison M, Walpole C, Radford KJ, Kumar V, Woodruff TM, Ying TH, Ali A, Kaiko GE, Upham JW, Hoelzle RD, Cuív PÓ, Holt PG, Dennis PG, Phipps S. | 05/28/2023 |
| Class I PI3K regulatory subunits control differentiation of dendritic cell subsets and regulate Flt3L mediated signal transduction. | Class I PI3K regulatory subunits control differentiation of dendritic cell subsets and regulate Flt3L mediated signal transduction.
Thummar K, Rathinam CV., Free PMC Article | 07/30/2022 |
| FLT3 Ligand Is Dispensable for the Final Stage of Type 1 Conventional Dendritic Cell Differentiation. | FLT3 Ligand Is Dispensable for the Final Stage of Type 1 Conventional Dendritic Cell Differentiation.
Audiger C, Lesage S. | 04/3/2021 |
| Study demonstrated that conventional dendritic cells 2 (cDC2s) produced their own FLT3L and utilized the transmembrane metalloproteinase ADAM10 to shed membrane bound FLT3L into soluble forms. This process was crucial for cDC2s to develop and survive in the spleen. These findings likely represent cell-autonomous developmental and survival processes that enable cDC2s to preferentially gain access to FLT3L. | Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.
Fujita K, Chakarov S, Kobayashi T, Sakamoto K, Voisin B, Duan K, Nakagawa T, Horiuchi K, Amagai M, Ginhoux F, Nagao K., Free PMC Article | 04/4/2020 |
| Data indicate that combined over-expression of interleukin 7 (IL-7) and FMS-like tyrosine kinase 3 ligand (FL) leads to a massive expansion of most bone marrow hematopoietic progenitors. | Accumulation of Multipotent Hematopoietic Progenitors in Peripheral Lymphoid Organs of Mice Over-expressing Interleukin-7 and Flt3-Ligand.
Klein F, von Muenchow L, Capoferri G, Heiler S, Alberti-Servera L, Rolink H, Engdahl C, Rolink M, Mitrovic M, Cvijetic G, Andersson J, Ceredig R, Tsapogas P, Rolink A., Free PMC Article | 10/5/2019 |
| Fms-Like Tyrosine Kinase-3 Ligand Attenuates Local and Systemic Infection in a Model of Post-Burn Pneumonia. | Fms-Like Tyrosine Kinase-3 Ligand Attenuates Local and Systemic Infection in a Model of Post-Burn Pneumonia.
Hundeshagen G, Cui W, Musgrove L, Cherry A, Lee SJ, Cox RA, Toliver-Kinsky T. | 08/17/2019 |
| the discrepancy between Flt3(-/-) and Flt3l(-/-) mice results from the increased sensitivity of Flt3(-/-) progenitors to these cytokines. | Altered compensatory cytokine signaling underlies the discrepancy between Flt3(-/-) and Flt3l(-/-) mice.
Durai V, Bagadia P, Briseño CG, Theisen DJ, Iwata A, Davidson JT 4th, Gargaro M, Fremont DH, Murphy TL, Murphy KM., Free PMC Article | 06/22/2019 |
| These observations emphasize the potential of Flt3L as an adjuvant for colon cancer DNA vaccines. | Enhancement of anti-tumor effect of plasmid DNA-carrying MUC1 by the adjuvanticity of FLT3L in mouse model.
Gao FS, Zhan YT, Wang XD, Zhang C. | 12/22/2018 |
| our study demonstrates that Flt3L acts as an important regulator of ILCs lymphopoiesis and it can be used as a tool to expand and study ILCs precursors in the BM. | Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo.
Parigi SM, Czarnewski P, Das S, Steeg C, Brockmann L, Fernandez-Gaitero S, Yman V, Forkel M, Höög C, Mjösberg J, Westerberg L, Färnert A, Huber S, Jacobs T, Villablanca EJ., Free PMC Article | 11/17/2018 |
| Flt3L could enhance the efficacy of immune checkpoint blockades in glioblastoma via expanding CD103+ dendritic cells and downstream antitumor immune response. | CD103(+) Cell Growth Factor Flt3L Enhances the Efficacy of Immune Checkpoint Blockades in Murine Glioblastoma Model.
Miao X, Chen Y, Hao K, Zheng M, Chen B, Li K, Wang Y, Zhang W, Zhang Y, Mou X, Jiang S, Wang Z., Free PMC Article | 09/1/2018 |
| Intratumoral administration of the STING agonist cyclic di-GMP (CDG) or Flt3 Ligand (Flt3L) augmented the therapeutic effect of systemic triple checkpoint modulation and promoted the cure of 75% of mice with bilateral TRAMP-C2; however, when all agents were administered locally, only CDG mobilized abscopal immunity | Intratumoral STING Activation with T-cell Checkpoint Modulation Generates Systemic Antitumor Immunity.
Ager CR, Reilley MJ, Nicholas C, Bartkowiak T, Jaiswal AR, Curran MA., Free PMC Article | 04/28/2018 |
| both Flt3 ligand (FL) and IL-7 regulate B-cell commitment in a permissive manner: FL by inducing proliferation of Ly6D(+)CD135(+)CD127(+)CD19(-) progenitors and IL-7 by providing survival signals to these progenitors | Permissive roles of cytokines interleukin-7 and Flt3 ligand in mouse B-cell lineage commitment.
von Muenchow L, Alberti-Servera L, Klein F, Capoferri G, Finke D, Ceredig R, Rolink A, Tsapogas P., Free PMC Article | 04/7/2018 |
| Data show that FLT3 ligand (FLT3L) enhances thymopoiesis through increased survival and export of hematopoietic stem cell (Lin([minus])Sca1(+)c-Kit(+) [LSK] cells via CXCR4 receptor regulation. | FLT3 ligand regulates thymic precursor cells and hematopoietic stem cells through interactions with CXCR4 and the marrow niche.
Williams KM, Moore AR, Lucas PJ, Wang J, Bare CV, Gress RE., Free PMC Article | 10/28/2017 |
| these results demonstrate that the lack of Flt3L mRNA expression in hematopoietic stem cells is yet another marker which further defines the status of long-term repopulating -hematopoietic stem cells | Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150(+) long-term repopulating murine hematopoietic stem cells.
Tornack J, Kawano Y, Garbi N, Hämmerling GJ, Melchers F, Tsuneto M. | 10/14/2017 |
| this study shows that ionizing radiation induces a decrease of CD8+ dendritic cells and Th1/Th2 shift, which was reversed by Flt3 ligand treatment, suggesting a novel mechanism for radiation-induced immunosuppression | Radiation-induced decrease of CD8+ dendritic cells contributes to Th1/Th2 shift.
Liu H, Li B, Jia X, Ma Y, Gu Y, Zhang P, Wei Q, Cai J, Cui J, Gao F, Yang Y. | 06/24/2017 |
| may be mediated by Flt3L- and MMP-9-dependent mobilization of dendritic cells | Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis.
Deckx N, Wens I, Nuyts AH, Lee WP, Hens N, Koppen G, Goossens H, Van Damme P, Berneman ZN, Eijnde BO, Cools N., Free PMC Article | 10/1/2016 |
| Bone marrow-derived CD117+ hematopoietic progenitor cells differentiate into thymic dendritic cells in the fetal thymus organ culture system in the presence of Flt3L. | Fms-like tyrosine kinase 3 ligand is required for thymic dendritic cell generation from bone marrow-derived CD117⁺ hematopoietic progenitor cells.
Xu Y, Jiang D, Hu Y, Li Y, Zhang X, Wang J, Wang Y. | 08/20/2016 |
| Flt3L significantly contributes to innate lymphoid cells and Peyer's patches development by targeting lymphoid progenitor cells during fetal and adult life. | Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice.
Baerenwaldt A, von Burg N, Kreuzaler M, Sitte S, Horvath E, Peter A, Voehringer D, Rolink AG, Finke D. | 08/13/2016 |
| unlike G-CSF, Flt3-L had an indirect effect on EI macrophages, as it was not detected at the surface of EI macrophages or erythroid progenitors. | Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouse.
Jacobsen RN, Nowlan B, Brunck ME, Barbier V, Winkler IG, Levesque JP. | 08/6/2016 |
| Study showed shown Flt3L-dependent accumulation of a population of DNGR-1(CLEC9A)-EGFP+ CD45h CD11blow MHCII+ myeloid cells in the brain | DNGR-1(+) dendritic cells are located in meningeal membrane and choroid plexus of the noninjured brain.
Quintana E, Fernández A, Velasco P, de Andrés B, Liste I, Sancho D, Gaspar ML, Cano E. | 07/30/2016 |
| Data indicate that Flt3 ligand knockout (Flt3L-/-) mice are unable to control infection with Toxoplasma gondii. | Flt3 Ligand Is Essential for Survival and Protective Immune Responses during Toxoplasmosis.
Dupont CD, Harms Pritchard G, Hidano S, Christian DA, Wagage S, Muallem G, Tait Wojno ED, Hunter CA., Free PMC Article | 04/2/2016 |