| Ectopic Activation of Fgf8 in Dental Mesenchyme Causes Incisor Agenesis and Molar Microdontia. | Ectopic Activation of Fgf8 in Dental Mesenchyme Causes Incisor Agenesis and Molar Microdontia.
Wang Y, Wang J, Xu T, Yang S, Wang X, Zhu L, Li N, Liu B, Xiao J, Liu C., Free PMC Article | 07/18/2024 |
| Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8. | Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8.
Astrof S, Arriagada C, Saijoh Y, Francou A, Kelly RG, Moon A., Free PMC Article | 06/7/2023 |
| Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3. | Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3.
Cova G, Glaser J, Schöpflin R, Prada-Medina CA, Ali S, Franke M, Falcone R, Federer M, Ponzi E, Ficarella R, Novara F, Wittler L, Timmermann B, Gentile M, Zuffardi O, Spielmann M, Mundlos S., Free PMC Article | 04/5/2023 |
| Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis. | Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis.
Anderson MJ, Misaghian S, Sharma N, Perantoni AO, Lewandoski M., Free PMC Article | 03/20/2023 |
| Fibroblast growth factor 8 (FGF8) up-regulates gelatinase expression in chondrocytes through nuclear factor-kappaB p65. | Fibroblast growth factor 8 (FGF8) up-regulates gelatinase expression in chondrocytes through nuclear factor-κB p65.
Huang H, Xie J, Wei J, Xu S, Zhang D, Zhou X. | 02/11/2023 |
| FGF8 induces chemokinesis and regulates condensation of mouse nephron progenitor cells. | FGF8 induces chemokinesis and regulates condensation of mouse nephron progenitor cells.
Sharma A, Meer M, Dapkunas A, Ihermann-Hella A, Kuure S, Vainio SJ, Iber D, Naillat F. | 11/5/2022 |
| Position effects at the FGF8 locus are associated with femoral hypoplasia. | Position effects at the FGF8 locus are associated with femoral hypoplasia.
Socha M, Sowińska-Seidler A, Melo US, Kragesteen BK, Franke M, Heinrich V, Schöpflin R, Nagel I, Gruchy N, Mundlos S, Sreenivasan VKA, López C, Vingron M, Bukowska-Olech E, Spielmann M, Jamsheer A., Free PMC Article | 09/18/2021 |
| Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression. | Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression.
De Zoysa P, Liu J, Toubat O, Choi J, Moon A, Gill PS, Duarte A, Sucov HM, Kumar SR., Free PMC Article | 04/13/2021 |
| Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction. | Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.
Huh SH, Ha L, Jang HS., Free PMC Article | 03/13/2021 |
| Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy. | Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy.
Hörnblad A, Bastide S, Langenfeld K, Langa F, Spitz F., Free PMC Article | 02/6/2021 |
| Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle. | Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle.
Ratzan EM, Moon AM, Deans MR., Free PMC Article | 01/23/2021 |
| The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall. | The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.
Boylan M, Anderson MJ, Ornitz DM, Lewandoski M., Free PMC Article | 12/26/2020 |
| Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes. | Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes.
Westphal S, Gantert T, Kless C, Hüttinger K, Klingenspor M, Fromme T., Free PMC Article | 10/24/2020 |
| Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation. | Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.
Guzzetta A, Koska M, Rowton M, Sullivan KR, Jacobs-Li J, Kweon J, Hidalgo H, Eckart H, Hoffmann AD, Back R, Lozano S, Moon AM, Basu A, Bressan M, Pott S, Moskowitz IP., Free PMC Article | 09/5/2020 |
| GLI3R and downstream FGF8 signalling are responsible for CC defects observed in the ACLS and more generally in ciliopathies. | Altered GLI3 and FGF8 signaling underlies acrocallosal syndrome phenotypes in Kif7 depleted mice.
Putoux A, Baas D, Paschaki M, Morlé L, Maire C, Attié-Bitach T, Thomas S, Durand B. | 03/14/2020 |
| this study shows that Factor XIII prevents pulmonary emboli in mice by stabilizing deep vein thrombi | Factor XIII Prevents Pulmonary Emboli in Mice by Stabilizing Deep Vein Thrombi.
Shaya SA, Gani DM, Weitz JI, Kim PY, Gross PL. | 12/14/2019 |
| These data support a translational control of COUP-TFI gradient expression by FGF8 via miR-21 and contribute to our understanding of how regionalized expression is established during neocortical area mapping. | The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.
Terrigno M, Bertacchi M, Pandolfini L, Baumgart M, Calvello M, Cellerino A, Studer M, Cremisi F., Free PMC Article | 09/21/2019 |
| Fgf8 encodes the positional information required for thalamic nuclear regionalization and the development of thalamocortical projections. | Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer.
Botella-López A, Garcia-Lopez R, Pombero A, Martinez S., Free PMC Article | 07/6/2019 |
| mesenchymal cells of the skull are not fated to form bone, but can be forced into a chondrogenic fate through the manipulation of FGF8 signaling. | Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull.
Schmidt L, Taiyab A, Melvin VS, Jones KL, Williams T., Free PMC Article | 12/22/2018 |
| We demonstrate with genetic evidence that the Wnt5a gradient acts as a global cue that is instructive in establishing planar cell polarity (PCP) in the limb mesenchyme, and that Wnt5a also plays a permissive role to allow Fgf4 and Fgf8 signaling to orient PCP. | Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity.
Gao B, Ajima R, Yang W, Li C, Song H, Anderson MJ, Liu RR, Lewandoski MB, Yamaguchi TP, Yang Y., Free PMC Article | 06/9/2018 |
| THe Fgf8-Cre reporter expression in isthmic structures in mice include 'signature' isthmic structures in mice include the trochlear nucleus, the dorsal raphe nucleus, the microcellular tegmental nuclei, the pedunculotegmental nucleus, the vermis of the cerebellum, rostral parts of the parabrachial complex and locus coeruleus, and the caudal parts of the substantia nigra and VTA. | Mouse Fgf8-Cre-LacZ lineage analysis defines the territory of the postnatal mammalian isthmus.
Watson C, Shimogori T, Puelles L. | 04/28/2018 |
| Results indicate that perinatal fibroblast growth factor 8 (FGF8) signaling is important for the timing of the onset of anterior-dorsal glial fibrillary acidic protein expression in midline glial cells suggesting that FGF8 function regulates midline GFAP-IR glial cell development, which when disrupted by Fgf8 deficiency prevents the formation of the corpus callosum. | Perinatal midline astrocyte development is impaired in fibroblast growth factor 8 hypomorphic mice.
Stewart CE, Corella KM, Samberg BD, Jones PT, Linscott ML, Chung WCJ. | 07/22/2017 |
| The FBLN1/FGF8 interaction may also be involved in the survival of neural crest cell population during development. | Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: EFFECTS ON EMBRYO SURVIVAL.
Fresco VM, Kern CB, Mohammadi M, Twal WO., Free PMC Article | 05/20/2017 |
| These results indicate that the modulatory effects of SHH on BALB/c mouse metanephric explant cultures may involve the regulation of Fgf8 expression but not Fgf10 expression, which provides evidence for the functional role of Fgf proteins in renal morphogenesis. | Sonic hedgehog protein regulates fibroblast growth factor 8 expression in metanephric explant culture from BALB/c mice: Possible mechanisms associated with renal morphogenesis.
Chen X, Hou XM, Fan YF, Jin YT, Wang YL., Free PMC Article | 04/8/2017 |
| FGF-8 was revealed to suppress BMP-induced osteoblast differentiation through the ERK pathway and the effects were enhanced by TNF-alpha. | Regulatory effects of fibroblast growth factor-8 and tumor necrosis factor-α on osteoblast marker expression induced by bone morphogenetic protein-2.
Katsuyama T, Otsuka F, Terasaka T, Inagaki K, Takano-Narazaki M, Matsumoto Y, Sada KE, Makino H. | 09/3/2016 |